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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro.

Autor: Zhou F; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China; Clinical Pathology Department, Shandong Second Medical University, Shandong Province, Weifang, Shandong Province 261042, PR China., Shi Y; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Judicial Expertise, Department of Forensic Toxicology, Academy of Forensic Science, Ministry of Justice, Shanghai 200063, PR China., Tan S; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China., Wang X; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China., Yuan W; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China., Tao S; Clinical Pathology Department, Shandong Second Medical University, Shandong Province, Weifang, Shandong Province 261042, PR China., Xiang P; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Judicial Expertise, Department of Forensic Toxicology, Academy of Forensic Science, Ministry of Justice, Shanghai 200063, PR China., Cong B; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China., Ma C; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei Province 050017, PR China. Electronic address: chunlingma@hebmu.edu.cn., Wen D; College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province 050017, PR China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei Province 050017, PR China. Electronic address: wendi01125@hebmu.edu.cn.

Publikováno v: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Dec 10; Vol. 289, pp. 117500. Date of Electronic Publication: 2024 Dec 10.

Metabolism of Nine Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144 and XLR-11 in Human Urine Using LC-MS/MS

Autor: Florian Franz, Auwärter, S. Broecker, Simon D. Brandt, Stefan Kneisel, Melanie Hutter

Publikováno v: Current Pharmaceutical Biotechnology. 19:144-162

Background: `Herbal mixtures` containing synthetic cannabinoid receptor agonists (SCRAs) are promoted as legal alternative to marihuana and are easily available via the Internet. Keeping analytical methods for the detection of these SCRAs up-to-date

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5366db2c5f651f55e6e97e57993c6f50
https://doi.org/10.2174/1389201019666180509163114

JWH-019

Autor: Vance, Burt

Publikováno v: A Dictionary of Abbreviations, 1 ed., 2011.

Externí odkaz: http://www.oxfordreference.com/view/10.1093/acref/9780199698295.001.0001/acref-9780199698295-e-54416

Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet

Autor: Chieko Kanai, Jun’ichi Nakajima, Takako Seto, Masao Yoshida, Misako Takahashi, Tomoko Hamano, Jin Suzuki

Publikováno v: Forensic Toxicology. 29:95-110

During our careful surveillance of unregulated drugs, we found five new compounds used as adulterants in herbal and drug-like products obtained via the Internet. These compounds were identified by liquid chromatography–mass spectrometry, gas chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bea46a89e61118f7b0dbc13f6afff1e
https://doi.org/10.1007/s11419-011-0108-3