Zobrazeno 1 - 10
of 478
pro vyhledávání: '"JUN-ICHI MIYAZAKI"'
Autor:
Satsuki Miyazaki, Hiroyuki Yamano, Daisuke Motooka, Fumi Tashiro, Takumi Matsuura, Tatsushi Miyazaki, Jun-ichi Miyazaki
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296-knockout (KO) ESCs grew as flat colonies, which were reverted to rounded
Externí odkaz:
https://doaj.org/article/56ecfb3f40464fb3b48b41d4eb08d316
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract A pancreatic β-cell line MIN6 was previously established in our lab from an insulinoma developed in an IT6 transgenic mouse expressing the SV40 T antigen in β-cells. This cell line has been widely used for in vitro analysis of β-cell func
Externí odkaz:
https://doaj.org/article/3a8553a1292b4716a042124bd5ba0dad
Autor:
Hung-Wei Cheng, Lucas Onder, Mario Novkovic, Charlotte Soneson, Mechthild Lütge, Natalia Pikor, Elke Scandella, Mark D. Robinson, Jun-ichi Miyazaki, Anne Tersteegen, Ursula Sorg, Klaus Pfeffer, Thomas Rülicke, Thomas Hehlgans, Burkhard Ludewig
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The white pulp of spleen is an important immune structure dynamically modulated during development and immune responses. Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and di
Externí odkaz:
https://doaj.org/article/ba256f3e23034aedb297741e8c98ad23
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161190 (2016)
A promising approach to new diabetes therapies is to generate β cells from other differentiated pancreatic cells in vivo. Because the acinar cells represent the most abundant cell type in the pancreas, an attractive possibility is to reprogram acina
Externí odkaz:
https://doaj.org/article/cad8ada9c1a8479c91153fc913ebc443
Autor:
Masaki Kobayashi, Eiji Yamato, Koji Tanabe, Fumi Tashiro, Satsuki Miyazaki, Jun-ichi Miyazaki
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151927 (2016)
Elucidating the regulation of glucose-stimulated insulin secretion (GSIS) in pancreatic β cells is important for understanding and treating diabetes. The pancreatic β cell line, MIN6, retains GSIS but gradually loses it in long-term culture. The MI
Externí odkaz:
https://doaj.org/article/49180fa4aa334a2caf0b24e5cda1ab2e
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150390 (2016)
The unknown protein family 0224 (UPF0224) includes three members that are expressed in germ-line cells in mice: Gtsf1, Gtsf1l, and BC048502 (Gtsf2). These genes produce proteins with two repeats of the CHHC Zn-finger domain, a predicted RNA-binding m
Externí odkaz:
https://doaj.org/article/c394ea16372c4a37bea9aa6c5b25cd96
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101681 (2014)
Tissue-specific basic helix-loop-helix (bHLH) transcription factor proteins often play essential roles in cellular differentiation. The bHLH proteins SOHLH2 and SOHLH1 are expressed specifically in spermatogonia and oocytes and are required for early
Externí odkaz:
https://doaj.org/article/9aab4962abf24f7ba244b4d30e58e804
Autor:
Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L Szot, Rita Bottino, Seung K Kim
Publikováno v:
eLife, Vol 2 (2013)
Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of progeny that secrete insulin i
Externí odkaz:
https://doaj.org/article/d31f04dfd2b2453cadeb139439e5ffdf
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61211 (2013)
Elucidating the regulation of glucose-stimulated insulin secretion (GSIS) in pancreatic islet β cells is important for understanding and treating diabetes. MIN6 cells, a transformed β-cell line derived from a mouse insulinoma, retain GSIS and are a
Externí odkaz:
https://doaj.org/article/88ace9e7355042f688681bdcefe1f9da
Autor:
Tatsushi Miyazaki, Satsuki Miyazaki, Masafumi Ashida, Tomofumi Tanaka, Fumi Tashiro, Jun-ichi Miyazaki
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71645 (2013)
Tcl1 is highly expressed in embryonic stem (ES) cells, but its expression rapidly decreases following differentiation. To assess Tcl1's roles in ES cells, we generated Tcl1-deficient and -overexpressing mouse ES cell lines. We found that Tcl1 was nei
Externí odkaz:
https://doaj.org/article/5e08be7ac9534cc3afa0d641b0668c34