Zobrazeno 1 - 10
of 174
pro vyhledávání: '"JUDIT OVÁDI"'
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Intrinsically disordered proteins (IDPs), which can interact with many partner proteins, are central to many physiological functions and to various pathologies that include neurodegeneration. Here, we introduce the Sherpa hypothesis, accordi
Externí odkaz:
https://doaj.org/article/7dd45f5817ee46808b99c8c0e59e18a0
Publikováno v:
Cells, Vol 13, Iss 4, p 338 (2024)
Neurological disorders such as Parkinsonism cause serious socio-economic problems as there are, at present, only therapies that treat their symptoms. The well-established hallmark alpha-synuclein (SYN) is enriched in the inclusion bodies characterist
Externí odkaz:
https://doaj.org/article/87252d63408c4344882cf1ea7f258245
Publikováno v:
Cells, Vol 11, Iss 19, p 3025 (2022)
Parkinson’s disease is characterized by locomotion deficits, dopaminergic neuronal loss and alpha-synuclein (SYN) aggregates; the Tubulin Polymerization Promoting Protein (TPPP/p25 or TPPP1) is also implicated in these processes. The moonlighting a
Externí odkaz:
https://doaj.org/article/9242355b7db847f99d4cd914a9022b66
Autor:
Attila Lehotzky, Judit Oláh, János Tibor Fekete, Tibor Szénási, Edit Szabó, Balázs Győrffy, György Várady, Judit Ovádi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The pathological association of alpha-synuclein (SYN) and Tubulin Polymerization Promoting Protein (TPPP/p25) is a key factor in the etiology of synucleinopathies. In normal brains, the intrinsically disordered SYN and TPPP/p25 are not found together
Externí odkaz:
https://doaj.org/article/04f1ddc3853b4d3880713103d797d208
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1550 (2022)
Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a po
Externí odkaz:
https://doaj.org/article/c447f9107e804ed688b32dd21efb411e
Publikováno v:
Cells, Vol 10, Iss 11, p 2909 (2021)
DJ-1, a multi-functional protein with antioxidant properties, protects dopaminergic neurons against Parkinson’s disease (PD). The oligomerization/assembly of alpha-synuclein (SYN), promoted by Tubulin Polymerization Promoting Protein (TPPP/p25), is
Externí odkaz:
https://doaj.org/article/4895946aa1604e69b8204e8ea43c0786
Autor:
Victor Norris, Judit Ovádi
Publikováno v:
Cells, Vol 10, Iss 7, p 1818 (2021)
A novel coronavirus discovered in 2019 is a new strain of the Coronaviridae family (CoVs) that had not been previously identified in humans. It is known as SARS-CoV-2 for Severe Acute Respiratory Syndrome Coronavirus-2, whilst COVID-19 is the name of
Externí odkaz:
https://doaj.org/article/8ae45bb20ea94b0eac815b666df6f3a7
Publikováno v:
Cells, Vol 9, Iss 2, p 357 (2020)
The sensing, integrating, and coordinating features of the eukaryotic cells are achieved by the complex ultrastructural arrays and multifarious functions of the cytoskeleton, including the microtubule network. Microtubules play crucial roles achieved
Externí odkaz:
https://doaj.org/article/6344092954074840a11816e083fa222d
Autor:
Gábor G. Kovács, Lajos László, János Kovács, Poul Henning Jensen, Evo Lindersson, Gergő Botond, Tamás Molnár, András Perczel, Ferenc Hudecz, Gábor Mező, Anna Erdei, László Tirián, Attila Lehotzky, Ellen Gelpi, Herbert Budka, Judit Ovádi
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 155-162 (2004)
The novel basic, heat-stable tubulin polymerization promoting protein TPPP/p25 is associated with microtubules in vitro and can induce the formation of aberrant microtubule assemblies. We show by 1H-NMR spectroscopy that TPPP/p25 is natively unfolded
Externí odkaz:
https://doaj.org/article/9ee37665a9654341b7e5389ab5bdbc4c
Autor:
Nathalie Wössner, Wolfgang Sippl, Sören Hammelmann, Oliver Einsle, Manfred Jung, Judit Ovádi, Attila Lehotzky, Dina Robaa, Matthias Schiedel, Judit Oláh, Sándor Szunyogh
Publikováno v:
Chembiochem
We have discovered the sirtuin‐rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD+‐dependent lysine deacetylase sirtuin 2 (Sirt2). In previous studies, conjugation of a SirReal with a ligand for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fed718a545a63027ca8a0bc29d33ae
https://doi.org/10.1002/cbic.202000351
https://doi.org/10.1002/cbic.202000351