Zobrazeno 1 - 10
of 105
pro vyhledávání: '"JUAN DOMÍNGUEZ-BENDALA"'
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine an
Externí odkaz:
https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)
Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant
Externí odkaz:
https://doaj.org/article/4370bf27b2c441a0890f656127747865
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Dagmar Klein, Giacomo Lanzoni, Carlos García-Santana, Abelardo Montalvo, Fabiola Pláceres-Uray, Emilia Maria Cristina Mazza, Camillo Ricordi, Luca Alessandro Inverardi, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2408-2420 (2018)
Summary: Treatment of human pancreatic non-endocrine tissue with Bone Morphogenetic Protein 7 (BMP-7) leads to the formation of glucose-responsive β-like cells. Here, we show that BMP-7 acts on extrainsular cells expressing PDX1 and the BMP receptor
Externí odkaz:
https://doaj.org/article/2c05052cc5ed4b3f80bd04bc9324c419
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d
Autor:
Chris A. Fraker, Sirlene Cechin, Silvia Álvarez-Cubela, Felipe Echeverri, Andrés Bernal, Ramón Poo, Camillo Ricordi, Luca Inverardi, Juan Domínguez-Bendala
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Conventional culture vessels are not designed for physiological oxygen (O 2 ) delivery. Both hyperoxia and hypoxia—commonly observed when culturing cells in regular plasticware—have been linked to reduced cellular function and death. Pancreatic i
Externí odkaz:
https://doaj.org/article/686dc4fb6a30472090b1b5e99ef38f8d
Autor:
Dagmar Klein, Ryosuke Misawa, Valia Bravo-Egana, Nancy Vargas, Samuel Rosero, Julieta Piroso, Hirohito Ichii, Oliver Umland, Jiang Zhijie, Nicholas Tsinoremas, Camillo Ricordi, Luca Inverardi, Juan Domínguez-Bendala, Ricardo L Pastori
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55064 (2013)
microRNAs (miRNAs) play an important role in pancreatic development and adult β-cell physiology. Our hypothesis is based on the assumption that each islet cell type has a specific pattern of miRNA expression. We sought to determine the profile of mi
Externí odkaz:
https://doaj.org/article/4738bd41177742d4b656ffb781cc5f24
Autor:
Margarita Nieto, Pedro Hevia, Enrique Garcia, Dagmar Klein, Silvia Alvarez-Cubela, Valia Bravo-Egana, Samuel Rosero, R. Damaris Molano, Nancy Vargas, Camillo Ricordi, Antonello Pileggi, Juan Diez, Juan Domínguez-Bendala, Ricardo L. Pastori Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
MicroRNAs regulate gene expression by inhibiting translation or inducing target mRNA degradation. MicroRNAs regulate organ differentiation and embryonic development, including pancreatic specification and islet function. We showed previously that miR
Externí odkaz:
https://doaj.org/article/cfa475864245497c810c3461d43d5286
Autor:
Kamalaveni R. Prabakar, Juan Domínguez-Bendala, R. Damaris Molano, Antonello Pileggi, Susana Villate, Camillo Ricordi M.D., Luca Inverardi
Publikováno v:
Cell Transplantation, Vol 21 (2012)
We sought to assess the potential of human cord blood-derived mesenchymal stem cells (CB-MSCs) to derive insulin-producing, glucose-responsive cells. We show here that differentiation protocols based on stepwise culture conditions initially described
Externí odkaz:
https://doaj.org/article/1ec4eb5742b14cb385b4c2cd1b72e0a5
Autor:
Nancy Vargas, Silvia Álvarez-Cubela, Jaime A Giraldo, Margarita Nieto, Nicholas M Fort, Sirlene Cechin, Enrique García, Pedro Espino-Grosso, Christopher A Fraker, Camillo Ricordi, Luca Inverardi, Ricardo L Pastori, Juan Domínguez-Bendala
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22364 (2011)
Alongside Pdx1 and Beta2/NeuroD, the transcription factor MafA has been shown to be instrumental in the maintenance of the beta cell phenotype. Indeed, a combination of MafA, Pdx1 and Ngn3 (an upstream regulator of Beta2/NeuroD) was recently reported
Externí odkaz:
https://doaj.org/article/c77a0084b2e34d4f9d9c6b647d41f407
Publikováno v:
Cell Transplantation, Vol 15 (2006)
It is widely believed that human embryonic stem (huES) cells may represent a valid alternative to donor pancreata as a source of islets for transplantation. Much is known about the transcription factors whose sequential activation results in the gene
Externí odkaz:
https://doaj.org/article/ae8a50a9d77745dc9ed152020865205a