Monitoring clonal burden as an alternative to blast count for myelodysplastic neoplasm treatment response.

Autor: Jacoby MA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Duncavage ED; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Khanna A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Chang GS; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Nonavinkere Srivatsan S; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Miller CA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Gao F; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA., Robinson J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Shao J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Fulton RS; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Fronick CC; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., O'Laughlin M; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Heath SE; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Brendel K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Chavez M; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., DiPersio JF; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Abboud CN; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Stockerl-Goldstein K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Westervelt P; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; MaineHealth Cancer Center, Scarborough, ME, USA., Cashen A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Pusic I; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Oh ST; Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Welch JS; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; A2 Biotherapeutics Inc., Agoura Hills, CA, USA., Wells DA; Hematologics Inc., Seattle, WA, USA., Loken MR; Hematologics Inc., Seattle, WA, USA., Uy GL; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. guy@wustl.edu., Walter MJ; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. mjwalter@wustl.edu.

Publikováno v: Leukemia [Leukemia] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.

Molecular responses in decitabine- and decitabine/ venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes.

Autor: Gruszczynska A; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Maiti A; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas 77030., Miller CA; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Ramakrishnan SM; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Link DC; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Uy GL; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Petti AA; Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri 63110., Hayes K; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas 77030., DiNardo CD; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas 77030., Ravandi F; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas 77030., Ley TJ; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110., Spencer DH; Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110., Gao F; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri 63110., Konopleva MY; Albert Einstein College of Medicine, Bronx, New York 10461., Welch JS; Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110; A2 Biotherapeutics, Agoura Hills, California 91301 (work completed while at Washington University). jwelch@a2biotherapeutics.com.

Publikováno v: Haematologica [Haematologica] 2024 Aug 01; Vol. 109 (8), pp. 2653-2659. Date of Electronic Publication: 2024 Aug 01.

A global study for acute myeloid leukemia with RARG rearrangement.

Autor: Zhu HH; Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Qin YZ; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China., Zhang ZL; Department of Transfusion, Institute of Transfusion, Jiangxi Key Laboratory of Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, China., Liu YJ; Biomedical Big Data Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, China., Wen LJ; National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China., You MJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Zhang C; Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, China., Such E; Hematology Department, Hospital La Fe, Valencia, Spain., Luo H; Department of Hematology, The First Hospital of Qiqihar, Heilongjiang, Qiqihar, China., Yuan HJ; Department of Hematology, The Second People's Hospital of Taizhou, Taizhou, China., Zhou HS; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Liu HX; Molecular Medicine Center, Beijing Lu Daopei lnstitute of Hematology, Beijing, China., Xu R; Shanghai Righton Biotechnology Co. Ltd, Shanghai, China., Li J; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Li JH; Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, China., Hao JP; Department of Hematology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China., Jin J; Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center of Zhejiang University, Hangzhou, China., Yu L; Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huaian, China., Zhang JY; Department of Hematology-Oncology, The Children Hospital of Zhejiang University School of Medicine, Zhejiang Childhood Leukemia Diagnosis and Treatment Technology Research Center, National Medical Research Center for Child Health, Hangzhou, China., Liu LP; Department of Hematology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China., Zhang LP; Department of Pediatrics, Peking University People's Hospital, Beijing, China., Huang RB; Department of Hematology, The First Affiliated hospital of Nanchang University, Nanchang, China., Shen SH; Department of Hematology/Oncology, National Children's Medical Center, Key Laboratory of Pediatric Hematology and Oncology of China Ministry of Health, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Gao SJ; Department of Hematology, the First Hospital of Jilin University, Changchun, Jilin, China., Wang W; Department of Hematology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Yan XJ; Department of Hematology, First Hospital of China Medical University, Shenyang, China., Zhang XY; Department of Hematology, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China., Du X; Department of Hematology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China., Chu XX; Department of Hematology, Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Yantai, China., Yu YF; Department of Hematology, Peking University Shougang Hospital, Beijing, China., Wang Y; Department of Hematology, Provincial People Hospital, Xian, Shaanxi, China., Mi YC; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Lu Y; Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, China., Cai Z; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Su Z; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China., Taussig DC; Centre for Molecular Pathology, The Royal Marsden, Institute of Cancer Research, Sutton, United Kingdom., MacMahon S; Centre for Molecular Pathology, The Royal Marsden, Institute of Cancer Research, Sutton, United Kingdom., Ball ED; Division of Blood and Marrow Transplantation, Department of Medicine, University of California, San Diego, La Jolla, CA., Wang HY; Division of Blood and Marrow Transplantation, Department of Medicine, University of California, San Diego, La Jolla, CA., Welch JS; Department of Internal Medicine, Washington University, St. Louis, MO., Yin CC; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Borthakur G; Department of Leukemia, MD Anderson Cancer Center, Houston, TX., Sanz MA; Hematology Department, Hospital La Fe, Valencia, Spain., Kantarjian HM; Department of Leukemia, MD Anderson Cancer Center, Houston, TX., Huang JY; Biomedical Big Data Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, China., Hu J; Department of Hematology, Shanghai Institute of Hematology, Blood and Marrow Transplantation Center, and Collaborative Innovation Center of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Chen SN; National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.

Publikováno v: Blood advances [Blood Adv] 2023 Jul 11; Vol. 7 (13), pp. 2972-2982.

Distinct clonal identities of B-ALLs arising after lenolidomide therapy for multiple myeloma.

Autor: Barnell EK; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Department of Medicine, Washington University School of Medicine, St. Louis, MO., Skidmore ZL; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Department of Medicine, Washington University School of Medicine, St. Louis, MO., Newcomer KF; Department of Surgery, Washington University School of Medicine, St. Louis, MO., Chavez M; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Campbell KM; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Department of Medicine, Washington University School of Medicine, St. Louis, MO., Cotto KC; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Department of Medicine, Washington University School of Medicine, St. Louis, MO., Spies NC; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Ruzinova MB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Wang T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Abro B; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Kreisel F; Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO., Parikh BA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Duncavage EJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Frater JL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Lee YS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Hassan A; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., King JA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Kohnen DR; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Fiala MA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Welch JS; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Uy GL; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO., Vij K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Vij R; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO., Griffith M; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.; Department of Genetics, Washington University School of Medicine, St. Louis, MO., Griffith OL; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.; Department of Genetics, Washington University School of Medicine, St. Louis, MO., Wartman LD; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.

Publikováno v: Blood advances [Blood Adv] 2023 Jan 24; Vol. 7 (2), pp. 236-245.

Genomic Immune Evasion: Diagnostic and Therapeutic Opportunities in Head and Neck Squamous Cell Carcinomas.

Autor: Kirtane K; Moffitt Cancer Center, Tampa, FL 33612, USA., St John M; Otolaryngology, UCLA School of Medicine, Los Angeles, CA 90095, USA., Fuentes-Bayne H; Mayo Clinic, Rochester, MN 55902, USA., Patel SP; Moores Cancer Center, UCSD School of Medicine, San Diego, CA 92093, USA., Mardiros A; A2 Biotherapeutics, Agoura Hills, CA 91301, USA., Xu H; A2 Biotherapeutics, Agoura Hills, CA 91301, USA., Ng EW; A2 Biotherapeutics, Agoura Hills, CA 91301, USA., Go WY; A2 Biotherapeutics, Agoura Hills, CA 91301, USA., Wong DJ; Otolaryngology, UCLA School of Medicine, Los Angeles, CA 90095, USA., Sunwoo JB; Otolaryngology, Stanford University, Palo Alto, CA 94305, USA., Welch JS; A2 Biotherapeutics, Agoura Hills, CA 91301, USA.

Publikováno v: Journal of clinical medicine [J Clin Med] 2022 Dec 07; Vol. 11 (24). Date of Electronic Publication: 2022 Dec 07.