Výsledky vyhledávání

Abstract P3-06-18: Comprehensive genomic profiling of carcinosarcomas of the breast

Autor: LM Gay, JA Elvin, J-A Vergilio, JK Killian, S Ramkissoon, E Severson, S Daniel, A Hammerich, E Sokol, G Frampton, J Chung, S Trabucco, S Ali, P Reddy, AB Schrock, VA Miller, JS Ross

Publikováno v: Cancer Research. 79:P3-06

Background: Carcinosarcomas of the breast (BCSC) are exceptionally rare and the underlying genomic drivers are still being elucidated. Comprehensive genomic profiling (CGP) determines the tumor mutation burden (TMB) and identifies all four classes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0364cff9d039f3fba3948878c918ee
https://doi.org/10.1158/1538-7445.sabcs18-p3-06-18

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Abstract P2-09-15: NTRK fusions in breast cancer: Clinical, pathologic and genomic findings

Autor: JS Ross, J Chung, JE Elvin, J-A Vergilio, S Ramkissoon, J Suh, E Severson, S Daniel, GM Frampton, D Fabrizio, RJ Hartmaier, LA Albacker, SM Ali, AB Schrock, VA Miller, PJ Stephens, LM Gay

Publikováno v: Cancer Research. 78:P2-09

Background: The tropomysin receptor kinase A family includes the 3 NTRK1, NTRK2 and NTRK3 genes and plays major roles in neuronal development. The recent evidence of remarkable efficacy for kinase inhibitors (TKI) targeting NTRK across a wide variety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4b8073a0a60f01beaf32cf13a2c573e
https://doi.org/10.1158/1538-7445.sabcs17-p2-09-15

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Abstract P5-21-20: Integrating comprehensive genomic profiling with treatment decisions – Experience gained while treating 139 advanced breast carcinomas

Autor: R Mahtani, LM Gay, J Chung, R Hartmaier, E Sokol, JA Elvin, S Daniel, S Ramkissoon, E Severson, J Suh, J-A Vergilio, PJ Stephens, JS Ross

Publikováno v: Cancer Research. 78:P5-21

Background: Comprehensive Genomic Profiling (CGP) using next-generation sequencing (NGS) technology can provide insight into potentially clinically relevant genomic alterations (CRGA) within a patient's breast cancer. For example, HER2 amplification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e99220aa225a68dcb4987933ba04950
https://doi.org/10.1158/1538-7445.sabcs17-p5-21-20

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Abstract P3-07-02: Are we missing actionable targets in breast cancer? Novel insights into recurrent Ret alterations

Autor: KM Hirshfield, BS Paratala, A Hindoyan, SC Dolfi, B Yilmazel, A Schrock, L Gay, SM Ali, JS Ross, CB Williams, P Nair, S Ganesan, B Leyland-Jones

Publikováno v: Cancer Research. 77:P3-07

Background: Recurrent gene fusions in breast cancer have been rarely reported suggesting that they either are not present or are not easily detected by standard sequencing methods. Comprehensive genomic profiling (CGP) by hybrid capture-based, high d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbc162f4d4236fd224a95ccb28cff5c5
https://doi.org/10.1158/1538-7445.sabcs16-p3-07-02

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Abstract P2-12-01: Comprehensive genomic profiling of 34 cases of breast angiosarcoma

Autor: V Ravi, R Madison, AB Schrock, G Cote, S Millis, R Alvarez, E Choy, D Katz, J Chung, L Gay, VA Miller, JS Ross, SM Ali, S Schnitt

Publikováno v: Cancer Research. 77:P2-12

Background: Angiosarcoma of the breast (BAS) is a rare but lethal neoplasia, either arising de novo or secondary to radiation therapy, with incidence of the latter disease increasing. We queried a database of more than 70,000 advanced cancer patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8328def4c907878cdc57ac3d5c1a0d55
https://doi.org/10.1158/1538-7445.sabcs16-p2-12-01

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Abstract P1-05-07: Comprehensive genomic profiling of clinically malignant phyllodes tumors of the breast reveals frequent mutation of NF1 and other genes associated with PI3K and RAS pathway activation

Autor: LM Gay, JA Elvin, J-A Vergilio, J Suh, S Ramkissoon, S Ali, A Schrock, K Hirshfield, S Ganesan, VA Miller, PJ Stephens, JS Ross

Publikováno v: Cancer Research. 77:P1-05

Background: Malignant or metastatic breast phyllodes tumors (MPT) are exceptionally rare, and the underlying genomic drivers are still being elucidated. Recent studies report frequent mutations in the RAS and PI3K pathways but have not commonly repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e3861e73d01f05ebfbb2ef28b1638e7
https://doi.org/10.1158/1538-7445.sabcs16-p1-05-07

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Abstract P1-05-08: Comprehensive genomic profiling of 8,654 breast carcinoma reveals therapeutically targetable molecular subtypes beyond those defined by hormone-receptor expression

Autor: JS Ross, LM Gay, JA Elvin, J Suh, J-A Vergilio, S Ramkissoon, A Schrock, S Ali, VA Miller, PJ Stephens

Publikováno v: Cancer Research. 77:P1-05

Background: Breast carcinomas (BC) are commonly classified into 4 subtypes based on hormone receptor expression: basal, luminal A, luminal B, and HER2 overexpressed. Comprehensive genomic profiling (CGP) reveals targetable genomic alterations (GA) ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d61bdfc0debeec83178459226bcb3ff9
https://doi.org/10.1158/1538-7445.sabcs16-p1-05-08

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Abstract PD8-01: CDH1 mutated classic and pleomorphic invasive lobular breast carcinomas differ in genomic signatures and opportunities for targeted and immunotherapies

Autor: JS Ross, J Chung, JE Elvin, J-A Vergilio, S Ramkissoon, J Suh, E Severson, S Daniel, GM Frampton, D Fabrizio, RJ Hartmaier, LA Albacker, SM Ali, AB Schrock, VA Miller, PJ Stephens, LM Gay

Publikováno v: Cancer Research. 78:PD8-01

Background: Typically defined by negative IHC staining for E-cadherin, classic (CILC) and pleomorphic (PILC) are often combined as a single breast cancer subtype. We queried whether patients with relapsed metastatic disease, mCILC and mPILC, would ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b3a044b20641eb707ff270a21ebb7f
https://doi.org/10.1158/1538-7445.sabcs17-pd8-01

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Abstract P6-07-05: Regional variation in Medicare expenditures for older women with localized breast cancer

Autor: JS Ross, Brigid K. Killelea, A Saraf, R Wang, Kenneth B. Roberts, X Xu, Xiaomei Ma, Jeph Herrin, Jessica B. Long, Pamela R. Soulos, Cary P. Gross, Shi-Yi Wang

Publikováno v: Cancer Research. 73:P6-07

Objectives: To characterize variation in Medicare expenditures on initial breast cancer care across hospital referral regions (HRRs) and to examine the relative contribution of patient characteristics and treatment factors to such variation. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce46e35fe44763786f4c49b8d1ab320d
https://doi.org/10.1158/0008-5472.sabcs13-p6-07-05

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Unattended automated elemental analysis of fibrous and non-fibrous inorganic particulates

Autor: C.E. Sheehan, JK Singh, JS Ross, JM Mastovich, R.J. Emerson

Publikováno v: Proceedings, annual meeting, Electron Microscopy Society of America. 50:948-949

Automated identification and analysis of inorganic particulates by Scanning Electron Microscopy (SEM) and energy dispersive x-ray analysis (EDX) has been established for many years. Our laboratory has developed and refined a procedure for unattended

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed5de2566070e77ba8651bce2ff3373a
https://doi.org/10.1017/s0424820100129371

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