Abstract P6-17-13: ZW49, a HER2 targeted biparatopic antibody drug conjugate for the treatment of HER2 expressing cancers

Autor: KJ Hamblett, SD Barnscher, RH Davies, PW Hammond, A Hernandez, GR Wickman, VK Fung, T Ding, G Garnett, AS Galey, P Zwierzchowski, BC Clavette, GC Winters, JR Rich, GJ Rowse, JS Babcook, D Hausman

Publikováno v: Cancer Research. 79:P6-17

Background: HER2-targeted therapies have transformed the treatment of patients with HER2-expressing breast and gastric cancers. Despite this, there remains a need for new treatments that are well tolerated and effective not only for cancers with high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74faa4d5b0c91d31f04e75d7369d50ff
https://doi.org/10.1158/1538-7445.sabcs18-p6-17-13

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.

Autor: Salanti A; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark. Electronic address: salanti@sund.ku.dk., Clausen TM; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada., Agerbæk MØ; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada., Al Nakouzi N; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada., Dahlbäck M; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Oo HZ; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada., Lee S; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada., Gustavsson T; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Rich JR; Kairos Therapeutics, Inc., Vancouver, BC V6T 1Z3, Canada; Centre for Drug Research and Development, Vancouver, BC V6T 1Z3, Canada., Hedberg BJ; Kairos Therapeutics, Inc., Vancouver, BC V6T 1Z3, Canada; Centre for Drug Research and Development, Vancouver, BC V6T 1Z3, Canada., Mao Y; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA., Barington L; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Pereira MA; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., LoBello J; Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA., Endo M; Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada; Department of Anatomic Pathology, Kyushu University, Fukuoka 812-8582, Japan; Department of Orthopaedic Surgery, Kyushu University, Fukuoka 819-0395, Japan., Fazli L; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada., Soden J; Retrogenix Ltd., Crown House, Bingswood Estate, Whaley Bridge, High Peak SK23 7LY, UK., Wang CK; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada., Sander AF; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Dagil R; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Thrane S; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Holst PJ; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Meng L; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA., Favero F; Centre for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark., Weiss GJ; Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA; Cancer Treatment Centers of America, Goodyear, AZ 85338, USA., Nielsen MA; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Freeth J; Retrogenix Ltd., Crown House, Bingswood Estate, Whaley Bridge, High Peak SK23 7LY, UK., Nielsen TO; Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Zaia J; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA., Tran NL; Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA., Trent J; Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA., Babcook JS; Kairos Therapeutics, Inc., Vancouver, BC V6T 1Z3, Canada; Centre for Drug Research and Development, Vancouver, BC V6T 1Z3, Canada., Theander TG; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, 1014 Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen, Denmark., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada., Daugaard M; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada. Electronic address: mads.daugaard@ubc.ca.

Publikováno v: Cancer cell [Cancer Cell] 2015 Oct 12; Vol. 28 (4), pp. 500-514.

Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.

Autor: Snyder KA; The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. ksnyder@brc.ubc.ca., Hughes MR; The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. mhughes@brc.ubc.ca., Hedberg B; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. bhedberg@cdrd.ca., Brandon J; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. jbrandon@cdrd.ca., Hernaez DC; The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. dcanals@brc.ubc.ca., Bergqvist P; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. pbergqvist@cdrd.ca., Cruz F; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. ecruz@cdrd.ca., Po K; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. kpo@cdrd.ca., Graves ML; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. mgraves@mail.ubc.ca., Turvey ME; Centre for Molecular Pathology, School of Molecular & Biological Science, The University of Adelaide, Adelaide, SA, 5005, Australia. michelle.turvey@adelaide.edu.au., Nielsen JS; The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. jnielsen@bccancer.bc.ca., Wilkins JA; Department of Internal Medicine, Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada. john.wilkins@med.umanitoba.ca., McColl SR; Centre for Molecular Pathology, School of Molecular & Biological Science, The University of Adelaide, Adelaide, SA, 5005, Australia. shaun.mccoll@adelaide.edu.au., Babcook JS; Centre for Drug Research and Development, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. jbabcook@cdrd.ca., Roskelley CD; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. roskelly@mail.ubc.ca., McNagny KM; The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. kelly@brc.ubc.ca.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2015 Mar 27; Vol. 17, pp. 46. Date of Electronic Publication: 2015 Mar 27.

Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse.

Autor: Coughlin M; Department of Microbiology and Immunology (MC790) College of Medicine, University of Illinois at Chicago, Room E705. 835 S. Wolcott AveChicago, IL 60612, USA., Lou G, Martinez O, Masterman SK, Olsen OA, Moksa AA, Farzan M, Babcook JS, Prabhakar BS

Publikováno v: Virology [Virology] 2007 Apr 25; Vol. 361 (1), pp. 93-102. Date of Electronic Publication: 2006 Dec 11.

P504S: a new molecular marker for the detection of prostate carcinoma.

Autor: Jiang Z; Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. jiangz@ummhc.org, Woda BA, Rock KL, Xu Y, Savas L, Khan A, Pihan G, Cai F, Babcook JS, Rathanaswami P, Reed SG, Xu J, Fanger GR

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2001 Nov; Vol. 25 (11), pp. 1397-404.