Zobrazeno 1 - 10
of 1 021
pro vyhledávání: '"JQ1"'
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 6717-6730 (2024)
Kebang Hu,1 Dongqi Zhang,1 Weiran Ma,2 Yanzhi Gu,2 Jiang Zhao,3 Xupeng Mu4 1Department of Urology, Lequn Branch, The First Hospital of Jilin University, Changchun, 130031, People’s Republic of China; 2College of Pharmacy, Jilin University, Changchu
Externí odkaz:
https://doaj.org/article/aa12a9f150214dfb8014c119cd9bae29
Autor:
Siying Yu, Linna Long, Xiaorui Zhang, Yu Qiu, Yabo Huang, Xueying Huang, Xia Li, Rong Xu, Chunmei Fan, He Huang
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36888- (2024)
Background: BET family proteins are important epigenetic and transcriptional regulators involved in the control of tumorigenesis and development and have become important targets for cancer therapy. However, there is no systematic bibliometric analys
Externí odkaz:
https://doaj.org/article/e8eba315ef194427952b4941856f7ae4
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Injury to contractile organs such as the heart, vasculature, urinary bladder and gut can stimulate a pathological response that results in loss of normal contractility. PDGF and TGFβ are among the most well studied initiators of
Externí odkaz:
https://doaj.org/article/6ed9524bb9f944b0ae10a25c78d7ed3e
Publikováno v:
Research in Pharmaceutical Sciences, Vol 19, Iss 1, Pp 53-63 (2024)
Background and purpose: Ovarian cancer is the deadliest gynecological cancer. Bromodomain and extra terminal domain (BET) proteins play major roles in the regulation of gene expression at the epigenetic level. Jun Qi (JQ1) is a potent inhibitor of BE
Externí odkaz:
https://doaj.org/article/d71683c114e0408b82a9ed62ed9208f6
Autor:
Eleonora Franzè, Federica Laudisi, Rachele Frascatani, Lorenzo Tomassini, Elena De Cristofaro, Carmine Stolfi, Giovanni Monteleone
Publikováno v:
Cells, Vol 13, Iss 20, p 1698 (2024)
Experimental evidence suggests that, in the inflamed gut of inflammatory bowel disease (IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways. Factors/mechanisms regulating IL-34 production in IBD remain poorly characterized.
Externí odkaz:
https://doaj.org/article/d755624a740c4cbc9b742091c717e27d
Akademický článek
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Publikováno v:
Cells, Vol 13, Iss 17, p 1443 (2024)
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and e
Externí odkaz:
https://doaj.org/article/5645efaaa8624612a6e767075703824a
Publikováno v:
PeerJ, Vol 12, p e17035 (2024)
Objective To investigate the effects of bromine domain protein 4 (BRD4) inhibitor JQ1 on the expression profile of super-enhancer-related lncRNAs (SE-lncRNAs) and mRNAs in cervical cancer (CC) HeLa-cells. Methods The CCK8 method was implemented to de
Externí odkaz:
https://doaj.org/article/3aa3d226fd76419ba7ab36f51791b4f0
Autor:
Aide Negri, Marina Marozzi, Daniela Trisciuoglio, Dante Rotili, Antonello Mai, Federica Rizzi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC). However, after a certain period of responsiveness, ADT resistance occurs virtually in all patients and the disease progresses to lethal metastatic castration
Externí odkaz:
https://doaj.org/article/23a51c8269fc43c7afe46977b921f61a
Analysis of differentially expressed long non-coding RNAs in LPS-induced human HMC3 microglial cells
Autor:
Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Long non-coding RNAs (lncRNAs) are emerging as key modulators of inflammatory gene expression, but their roles in neuroinflammation are poorly understood. Here, we identified the inflammation-related lncRNAs and correlated mRNAs o
Externí odkaz:
https://doaj.org/article/4b447e2a22fc4c1f8c16d2053af8ccaf