Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

Autor: Bt, Devree, Jp, Mahoney, Ga, Vélez-Ruiz, Sg, Rasmussen, Aj, Kuszak, Edwald E, Jj, Fung, Manglik A, Masureel M, Du Y, Ra, Matt, Pardon E, Jan Steyaert, Bk, Kobilka, Rk, Sunahara

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8e55f5888f081c92293adb43a9bbf96d
http://europepmc.org/abstract/med/27362234

PI(4,5)P 2 -stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-catenin signaling.

Autor: Mahoney JP; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Bruguera ES; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Vasishtha M; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Killingsworth LB; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Kyaw S; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Weis WI; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA.

Publikováno v: Science signaling [Sci Signal] 2022 Aug 23; Vol. 15 (748), pp. eabo2820. Date of Electronic Publication: 2022 Aug 23.

Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.

Autor: Nguyen AH; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Thomsen ARB; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Cahill TJ 3rd; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Huang R; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA., Huang LY; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Marcink T; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Host-Pathogen Interaction, Columbia University Irving Medical Center, New York, NY, USA., Clarke OB; Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; The Irving Center for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA., Heissel S; Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Masoudi A; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Ben-Hail D; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, USA., Samaan F; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, USA., Dandey VP; The National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA., Tan YZ; The National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Hong C; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA., Mahoney JP; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.; Department of Structural Biology, Stanford University, Stanford, CA, USA., Triest S; Structural Biology Brussels, Vrije Universiteit Brussels, Brussels, Belgium.; Structural Biology Research Center, Vlaams Instituut voor Biotechnologie, Brussels, Belgium., Little J 4th; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Chen X; School of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, China., Sunahara R; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussels, Brussels, Belgium., Molina H; Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Yu Z; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA., des Georges A; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, USA. adesgeorges@gc.cuny.edu.; Department of Chemistry and Biochemistry, City College of New York, New York, NY, USA. adesgeorges@gc.cuny.edu.; Biochemistry and Chemistry PhD Programs, Graduate Center, City University of New York, New York, NY, USA. adesgeorges@gc.cuny.edu., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Dec; Vol. 26 (12), pp. 1123-1131. Date of Electronic Publication: 2019 Nov 18.

Structural insights into binding specificity, efficacy and bias of a β 2 AR partial agonist.

Autor: Masureel M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zou Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Geneus Technologies, Ltd, Chengdu, Sichuan, People's Republic of China., Picard LP; Department of Biochemistry, Institute for Research in Immunology and Cancer, Université de Montreal, Montreal, Québec, Canada., van der Westhuizen E; Department of Biochemistry, Institute for Research in Immunology and Cancer, Université de Montreal, Montreal, Québec, Canada.; Monash Institute for Pharmaceutical Sciences, Monash University, Victoria, Australia., Mahoney JP; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Rodrigues JPGLM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Structural Biology, Stanford University, Stanford, CA, USA., Mildorf TJ; D. E. Shaw Research, New York, NY, USA.; Dropbox, New York, NY, USA., Dror RO; D. E. Shaw Research, New York, NY, USA.; Department of Computer Science and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA., Shaw DE; D. E. Shaw Research, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Bouvier M; Department of Biochemistry, Institute for Research in Immunology and Cancer, Université de Montreal, Montreal, Québec, Canada., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; Structural Biology Research Center, VIB, Brussels, Belgium., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; Structural Biology Research Center, VIB, Brussels, Belgium., Sunahara RK; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA., Weis WI; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University, Stanford, CA, USA., Zhang C; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. chengzh@pitt.edu., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2018 Nov; Vol. 14 (11), pp. 1059-1066. Date of Electronic Publication: 2018 Oct 16.

Mechanistic insights into GPCR-G protein interactions.

Autor: Mahoney JP; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States., Sunahara RK; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, United States. Electronic address: rsunahara@ucsd.edu.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2016 Dec; Vol. 41, pp. 247-254. Date of Electronic Publication: 2016 Nov 18.