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PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

Autor: Syeda, Fahima, Holmes, Andrew P., Yu, Ting Y., Tull, Samantha, Kuhlmann, Stefan Michael, Pavlovic, Davor, Betney, Daniel, Riley, Genna, Kucera, Jan P., Jousset, Florian, de Groot, Joris R., Rohr, Stephan, Brown, Nigel A., Fabritz, Larissa, Kirchhof, Paulus

Publikováno v: Journal of the American College of Cardiology

Background Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness are not known. Recent data suggested that paired like homeodomain-2 transcription factor (PITX2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bd22213c18a1fae9540fd2f6bd1ce7ad
http://europepmc.org/articles/PMC5075046

Kinetics of Atrial Repolarization Alternans in a Free-Behaving Ovine Model.

Autor: JOUSSET, FLORIAN¹ (AUTHOR), TENKORANG, JOANNA² (AUTHOR), VESIN, JEAN‐MARC¹ (AUTHOR), PASCALE, PATRIZIO² (AUTHOR), RUCHAT, PATRICK³ (AUTHOR), ROLLIN, ANNE GARDERES² (AUTHOR), FROMER, MARTIN² (AUTHOR), NARAYAN, SANJIV M.⁴ (AUTHOR), PRUVOT, ETIENNE² (AUTHOR)

Publikováno v: Journal of Cardiovascular Electrophysiology. Sep2012, Vol. 23 Issue 9, p1003-1012. 10p. 1 Chart, 6 Graphs.

Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias

Autor: Sottas Valentin, Rougier Jean-Sebastien, Jousset Florian, Kucera Jan P., Shestak Anna, Makarov Leonid M., Zaklyazminskaya Elena V., Abriel Hugues

Publikováno v: Journal of Cardiovascular Electrophysiology
Sottas, Valentin; Rougier, Jean-Sébastien; Jousset, Florian; Kucera, Jan P.; Shestak, Anna; Makarov, Leonid M.; Zaklyazminskaya, Elena V.; Abriel, Hugues (2013). Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias. Journal of cardiovascular electrophysiology, 24(9), pp. 1037-1046. Wiley-Blackwell 10.1111/jce.12173
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Hundreds of genetic variants in SCN5A, the gene coding for the pore-forming subunit of the cardiac sodium channel, Na(v) 1.5, have been described in patients with cardiac channelopathies as well as in individuals from control cohorts. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebd028d4e5b0610f0734ddca5a0c915
https://pubmed.ncbi.nlm.nih.gov/23692053

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