Zobrazeno 1 - 10
of 45
pro vyhledávání: '"JOSEPH E. LYNCH"'
Publikováno v:
Tetrahedron. 63:4459-4463
An efficient asymmetric synthesis of selective estrogen receptor β-modulator (S)-4-bromo-9a-butyl-8-chloro-6-fluoro-7-hydroxy-1,2,9,9a-tetrahydro-fluoren-3-one was developed. The route features a chemoselective aromatic chlorination reaction, an asy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed99a396419acba1e498e4ded3b93ca5
https://doi.org/10.1016/j.tet.2007.03.074
https://doi.org/10.1016/j.tet.2007.03.074
Publikováno v:
Organic Process Research & Development. 10:398-402
An expedient regioselective synthesis of a GABA α2/3 agonist 1 is described. The key step is an efficient regioselective palladium-catalyzed coupling of 7-trifluoromethylimidazo[1,2-a]pyrimidine (5) to 5‘-chloro-4,2‘-difluorobiphenyl-2-carbonitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6388c299b340f4a77a412d2e65d855fb
https://doi.org/10.1021/op050217j
https://doi.org/10.1021/op050217j
Autor:
Michael B. Hicks, Vincent Antonucci, George Zhou, Joseph E. Lynch, Mark Cameron, Yao-Jun Shi, David R. Lieberman, Zhihong Ge
Publikováno v:
Journal of Pharmaceutical Sciences. 92:529-535
A simple and safe prototype apparatus was designed and adapted for the in situ determination of the moisture content of a cytotoxic compound (9-fluorenylmethyl-protected doxorubicin-peptide conjugate, or Fm-DPC) by near-infrared absorbance spectrosco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991792bff59d0af18179cbb20c5a93cb
https://doi.org/10.1002/jps.10318
https://doi.org/10.1002/jps.10318
Autor:
Mark Cameron, Yao-Jun Shi, Paul J. Reider, Robert A. Reamer, Michael A. Robbins, Joseph E. Lynch, David R. Lieberman, Ralph P. Volante, Ulf H. Dolling
Publikováno v:
Synlett. :0647-0650
An efficient synthesis of the sodium salt of the doxorubicin-peptide conjugate 1, useful for the treatment of prostate cancer is described. The EDC-mediated amide formation between the heptapeptide 4 and doxorubicin (2) as the key step has been exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d7967274eb14f1aa39de74b15d10d74
https://doi.org/10.1055/s-2003-38368
https://doi.org/10.1055/s-2003-38368
Autor:
Ashok Maliakal, Joseph E. Lynch, Philip J. Pye, Ralph P. Volante, Paul J. Reider, Woo-Baeg Choi, Yao-Jun Shi, Kenneth M. Wells, Kai Rossen, Hywyn R.O. Churchill, Jess Sager
Publikováno v:
Tetrahedron. 55:909-918
A highly convergent, asymmetric synthesis of L-768,673, an I ks Class III antiarrythmic drug candidate, is described. Synthesis of the recemic 1-trifluoroethyl-3-amino-5-phenyl benzodiazepinone [(±)-amine] was achieved by Ru-catalyzed hydrogenation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358d55ce050e9d5aa5c54fcf76d77ed1
https://doi.org/10.1016/s0040-4020(98)01098-9
https://doi.org/10.1016/s0040-4020(98)01098-9
Publikováno v:
Tetrahedron Letters. 39:3679-3682
The use of cis -aminoindanol as a chiral auxiliary for asymmetric synthesis of α-amino acids is described. Alkylation of the chirally modified glycine enolate 2 with a number of alkyl halides in the presence of lithium chloride gave the correspondin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cdb618b19e3c3a6f44532de01fb2dab
https://doi.org/10.1016/s0040-4039(98)00636-4
https://doi.org/10.1016/s0040-4039(98)00636-4
Autor:
W.-B. Choi, and Robert A. Reamer, Hywyn R.O. Churchill, Ralph P. Volante, Richard G. Ball, Joseph E. Lynch
Publikováno v:
The Journal of Organic Chemistry. 62:9223-9228
An asymmetric synthesis of the PDE IV inhibitor, CDP840 (3) is reported. The absolute stereochemistry was controlled by a Jacobsen epoxidation of the Z triaryl olefin 8 (89% ee) or the E triaryl olefin 9 (48% ee). The disparate results in stereocontr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f2d9db72309341b348fa1282da8a87
https://doi.org/10.1021/jo971476c
https://doi.org/10.1021/jo971476c
Autor:
Kai Rossen, Ralph P. Volante, David Askin, Robert A. Reamer, Joseph E. Lynch, Veena Upadhyay, Paul J. Reider, Kenneth M. Wells, Ioannis N. Houpis, Jess Sager, Peter G. Houghton, Audrey Molina, Peter E. Maligres
Publikováno v:
Tetrahedron. 53:10983-10992
The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfac074b94c92a0e3e4c371fdd2accb3
https://doi.org/10.1016/s0040-4020(97)00359-1
https://doi.org/10.1016/s0040-4020(97)00359-1
Autor:
Ralph P. Volante, Yao Jun Shi, Paul J. Reider, Guy R. Humphrey, Kenneth M. Wells, Joseph E. Lynch
Publikováno v:
Tetrahedron Letters. 37:6439-6442
Regioselective nucleophilic substitutions of tri- and di-substituted fluorobenzoates, fluorobenzonitriles, and fluoronitrobenzenes were accomplished by sequential addition of various nucleophiles, such as, potassium N-Boc-4-piperidinyl oxide, potassi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c6552ce55bc8dac83396705eef00dc
https://doi.org/10.1016/0040-4039(96)01425-6
https://doi.org/10.1016/0040-4039(96)01425-6
Publikováno v:
The Journal of Organic Chemistry. 61:6425-6429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104e8ed76942692a5465a4ee3a0cadc3
https://doi.org/10.1021/jo960290v
https://doi.org/10.1021/jo960290v