Zobrazeno 1 - 10
of 795
pro vyhledávání: '"JOSEPH A. HILL"'
Autor:
Thaís A. R. Ramos, Sebastián Urquiza-Zurich, Soo Young Kim, Thomas G. Gillette, Joseph A. Hill, Sergio Lavandero, Thaís G. do Rêgo, Vinicius Maracaja-Coutinho
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Long non-coding RNAs (lncRNAs) comprise the most representative transcriptional units of the mammalian genome. They are associated with organ development linked with the emergence of cardiovascular diseases. We used bioinformatic approaches,
Externí odkaz:
https://doaj.org/article/05b4f3719b124166aa09006280eddb6a
Autor:
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R. Hemnes, Joseph A. Hill, JoAnn Lindenfeld, Sanjiv J. Shah, Lynne W. Stevenson, Thomas J. Wang, Deepak K. Gupta
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity. Correlates of natr
Externí odkaz:
https://doaj.org/article/80b00ca0968844f0ad38a83455bac4ff
Autor:
Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a084e9b1e94b4c3c8eb42688403bb233
Autor:
Binjie Yan, Yu Gui, Yanan Guo, Jiaxing Sun, Mahmoud Saifeddine, Jingti Deng, Joseph A. Hill, Morley D. Hollenberg, Zhi-Sheng Jiang, Xi-Long Zheng
Publikováno v:
Cells, Vol 12, Iss 11, p 1461 (2023)
(+)-JQ1, a specific chemical inhibitor of bromodomain and extraterminal (BET) family protein 4 (BRD4), has been reported to inhibit smooth muscle cell (SMC) proliferation and mouse neointima formation via BRD4 regulation and modulate endothelial nitr
Externí odkaz:
https://doaj.org/article/535596f615e049e9b1c483968d52f6c2
Autor:
Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine, Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for m
Externí odkaz:
https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825b
Autor:
Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Disease stress-induced cardiac hypertrophy is a major mechanism of pathological cardiac remodeling. Here, the authors unveil a previously unrecognized role of a FoxO1–Dio2 signaling axis in maladaptive, afterload-induced cardiac hypertrophy and int
Externí odkaz:
https://doaj.org/article/4b2c04dadb0144189152d9d80c25efb4
Autor:
Qing-Jun Zhang, Tram Anh T. Tran, Ming Wang, Mark J. Ranek, Kristen M. Kokkonen-Simon, Jason Gao, Xiang Luo, Wei Tan, Viktoriia Kyrychenko, Lan Liao, Jianming Xu, Joseph A. Hill, Eric N. Olson, David A. Kass, Elisabeth D. Martinez, Zhi-Ping Liu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacolog
Externí odkaz:
https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73b
Autor:
Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 1-17 (2018)
Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. Methods: Here we have exami
Externí odkaz:
https://doaj.org/article/b2b47e6a4e904925aa53b722a829c482
Autor:
Joseph A. Hill
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 3 (2019)
Externí odkaz:
https://doaj.org/article/f6dca30cf8394625a7eee39ef5c01a94
Autor:
Xiucui Ma, Kartik Mani, Haiyan Liu, Attila Kovacs, John T. Murphy, Layla Foroughi, Brent A. French, Carla J. Weinheimer, Aldi Kraja, Ivor J. Benjamin, Joseph A. Hill, Ali Javaheri, Abhinav Diwan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autop
Externí odkaz:
https://doaj.org/article/ad805593a61c4dcbbca1bbb8a105465c