Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Autor: Simon Kebede Merid, Alexei Novoloaca, Gemma C. Sharp, Leanne K. Küpers, Alvin T. Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O. Vehmeijer, Nabila Kazmi, Lucas A. Salas, Faisal I. Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L. Rifas-Shiman, Phillip E. Melton, Debbie A. Lawlor, Göran Pershagen, Carrie V. Breton, Karen Huen, Nour Baiz, Luigi Gagliardi, Tim S. Nawrot, Eva Corpeleijn, Patrice Perron, Liesbeth Duijts, Ellen Aagaard Nohr, Mariona Bustamante, Susan L. Ewart, Wilfried Karmaus, Shanshan Zhao, Christian M. Page, Zdenko Herceg, Marjo-Riitta Jarvelin, Jari Lahti, Andrea A. Baccarelli, Denise Anderson, Priyadarshini Kachroo, Caroline L. Relton, Anna Bergström, Brenda Eskenazi, Munawar Hussain Soomro, Paolo Vineis, Harold Snieder, Luigi Bouchard, Vincent W. Jaddoe, Thorkild I. A. Sørensen, Martine Vrijheid, S. Hasan Arshad, John W. Holloway, Siri E. Håberg, Per Magnus, Terence Dwyer, Elisabeth B. Binder, Dawn L. DeMeo, Judith M. Vonk, John Newnham, Kelan G. Tantisira, Inger Kull, Joseph L. Wiemels, Barbara Heude, Jordi Sunyer, Wenche Nystad, Monica C. Munthe-Kaas, Katri Räikkönen, Emily Oken, Rae-Chi Huang, Scott T. Weiss, Josep Maria Antó, Jean Bousquet, Ashish Kumar, Cilla Söderhäll, Catarina Almqvist, Andres Cardenas, Olena Gruzieva, Cheng-Jian Xu, Sarah E. Reese, Juha Kere, Petter Brodin, Olivia Solomon, Matthias Wielscher, Nina Holland, Akram Ghantous, Marie-France Hivert, Janine F. Felix, Gerard H. Koppelman, Stephanie J. London, Erik Melén

Publikováno v: Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)

Abstract Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between

Externí odkaz: https://doaj.org/article/63a99804af224399a4a483c0037dd871

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Autor: Simon Kebede Merid, Mariona Bustamante, Marie Standl, Jordi Sunyer, Joachim Heinrich, Nathanaël Lemonnier, Daniel Aguilar, Josep Maria Antó, Jean Bousquet, Loreto Santa-Marina, Aitana Lertxundi, Anna Bergström, Inger Kull, Åsa M. Wheelock, Gerard H. Koppelman, Erik Melén, Olena Gruzieva

Publikováno v: Environment International, Vol 146, Iss , Pp 106248- (2021)

Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-w

Externí odkaz: https://doaj.org/article/806d8a9fd2114e5db070d4f42967d9e3

The EASI model: A first integrative computational approximation to the natural history of COPD.

Autor: Alvar Agustí, Albert Compte, Rosa Faner, Judith Garcia-Aymerich, Guillaume Noell, Borja G Cosio, Robert Rodriguez-Roisin, Bartolomé Celli, Josep Maria Anto

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185502 (2017)

The natural history of chronic obstructive pulmonary disease (COPD) is still not well understood. Traditionally believed to be a self-inflicted disease by smoking, now we know that not all smokers develop COPD, that other inhaled pollutants different

Externí odkaz: https://doaj.org/article/f23b5cedc37446b8ab4659d5f699c6c9

Automobile accidents in patients with sleep apnea syndrome - An epidemiological and mechanistic study

Autor: FERRAN BARBÉ, JORDI PERICÁS, ARACELI MUÑOZ, LARRY FINDLEY, JOSEP MARÍA ANTÓ, ALVAR G.N. AGUSTÍ, MARIA de LLUC JOAN

Publikováno v: ResearcherID
Scopus-Elsevier

To investigate the association between sleep apnea syndrome (SAS) and automobile accidents, and to evaluate potential underlying mechanisms, we prospectively recruited 60 consecutive patients with SAS (apnea-hypopnea index, 58 +/- 3 h-1) and 60 healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020dba165a6ea8b3605c03a089e15992
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074730700004&KeyUID=WOS:000074730700004

A systematic review on the development of asthma and allergic diseases in relation to international immigration: the leading role of the environment confirmed.

Autor: Báltica Cabieses, Eleonora Uphoff, Mariona Pinart, Josep Maria Antó, John Wright

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105347 (2014)

BackgroundThe prevalence of asthma and allergic diseases is rising worldwide. Evidence on potential causal pathways of asthma and allergies is growing, but findings have been contradictory, particularly on the interplay between allergic diseases and

Externí odkaz: https://doaj.org/article/06765aa9038840bfa201fa807351a4a9