Zobrazeno 1 - 10
of 341
pro vyhledávání: '"JONATHAN HADGRAFT"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 909 (2021)
Ion pairing is a strategy used to increase the permeation of topically applied ionised drugs. Formation occurs when the electrostatic energy of attraction between oppositely charged ions exceeds their mean thermal energy, making it possible for them
Externí odkaz:
https://doaj.org/article/a645bc8fc27d4be3964602678a9df0a1
Autor:
Yanling Zhang, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 726 (2021)
In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell stu
Externí odkaz:
https://doaj.org/article/343038c89e20443cbd67af949b1bd387
Autor:
Chin-Ping Kung, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane, Bhumik Patel, Renée McCulloch
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 509 (2019)
The use of methadone for the management of pain has received great interest in recent years. Currently, oral and intravenous formulations are available for clinical use. Dermal delivery represents an attractive alternative route of administration for
Externí odkaz:
https://doaj.org/article/8d7494c3e54746278ab8830bb24f9f6d
Autor:
A. S. M. Monjur Al Hossain, Bruno C. Sil, Fotis Iliopoulos, Rebecca Lever, Jonathan Hadgraft, Majella E. Lane
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 548 (2019)
Terbinafine (TBF) is commonly used in the management of fungal infections of the skin because of its broad spectrum of activity. Currently, formulations containing the free base and salt form are available. However, there is only limited information
Externí odkaz:
https://doaj.org/article/b7b7b1334505421fbd439125cd534958
Autor:
Bruno C. Sil, Avnish Patel, Jonathan M. Crowther, David J. Moore, Jonathan Hadgraft, Stephen T. Hilton, Majella E. Lane
Publikováno v:
Pharmaceutics, Vol 11, Iss 6, p 250 (2019)
In vitro permeation studies using nail clippings or nail plates are commonly used in the development of transungual formulations. However, there are ethical, safety and cost issues associated with sourcing such tissues. Herein, we describe a prelimin
Externí odkaz:
https://doaj.org/article/61bec861a0db4a0099a064f4742fdb4f
This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like:Oral Ocular Dermal and transdermal VaginalColonic Oral mucosal Nasal PulmonaryProviding insight
Autor:
Renée McCulloch, Chin-Ping Kung, Bhumik Patel, Majella E. Lane, Jonathan Hadgraft, Bruno C. Sil, Yanling Zhang
Publikováno v:
Drug Delivery and Translational Research. 12:805-815
Abstract Amitriptyline, administered orally, is currently one of the treatment options for the management of neuropathic pain and migraine. Because of the physicochemical properties of the molecule, amitriptyline is also a promising candidate for del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a10bbbd1f947774d92dce10fa3112b
https://doi.org/10.1007/s13346-021-00982-x
https://doi.org/10.1007/s13346-021-00982-x
Autor:
Guoping Lian, Majella E. Lane, Bálint Sinkó, Tao Chen, Michael Heinrich, Yanling Zhang, Jonathan Hadgraft
Publikováno v:
International Journal of Pharmaceutics. 556:142-149
The in vitro skin penetration of pharmaceutical or cosmetic ingredients is usually assessed in human or animal tissue. However, there are ethical and practical difficulties associated with sourcing these materials; variability between donors may also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fb9a03f9af4a23f89c1abd06309263
https://doi.org/10.1016/j.ijpharm.2018.11.065
https://doi.org/10.1016/j.ijpharm.2018.11.065
Autor:
Richard H. Guy, Jonathan Hadgraft
This chapter describes biological and physicochemical parameters which determine the rate and extent of chemical penetration across human skin. It discusses how these parameters interact with the physicochemical properties of the dermally contacting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab545dcdc4174c33f61fd93c9d5a6fb
https://doi.org/10.1201/9781003069126-8
https://doi.org/10.1201/9781003069126-8
Autor:
Majella E. Lane, Chin-Ping Kung, Bhumik Patel, Jonathan Hadgraft, Bruno C. Sil, Yanling Zhang, Renée McCulloch
Publikováno v:
International journal of pharmaceutics. 586
Methadone appears to be a promising candidate for pain management. Previously, we conducted a comprehensive characterization study of methadone base and evaluated the dermal delivery of methadone from various neat solvents. Four solvents, namely d-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3add921a649127ab0efffad39b1d5d
https://pubmed.ncbi.nlm.nih.gov/32540347
https://pubmed.ncbi.nlm.nih.gov/32540347