Zobrazeno 1 - 10
of 30
pro vyhledávání: '"JONAS KILDEGAARD"'
Autor:
Mille K. Lyhne, Andreas Vegge, Gro Klitgaard Povlsen, Rita Slaaby, Jonas Kildegaard, Ulrik Pedersen-Bjergaard, Lisbeth H. Olsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The potentially fatal cardiovascular effects of hypoglycaemia are not well understood and large animal models of the counter-regulatory responses and cardiovascular consequences of insulin-induced hypoglycaemia are needed to understand the m
Externí odkaz:
https://doaj.org/article/76b2d03c79b64068a84ef05415463376
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f3cf07c418ea4af69c46d62c9eb076b7
Autor:
Thomas Hoeg-Jensen, Rita Slaaby, Thomas Kruse, Christian Lehn Brand, Jeppe Sturis, Christian Fledelius, Peter Nielsen, Erica Nishimura, Alice Madsen, Lennart Lykke, Kim Halskov, Simona Koscova, Vladaslav Kotek, Anthony Davis, Robert Tromans, Michael Tomsett, Guillem Penuelas-Haro, Daniel J. Leonard, Michael Orchard, Andy Chapman, Gaetano Invernizzi, Eva Johansson, Daniele Granata, Bo Hansen, Thomas Pedersen, Jonas Kildegaard, Karen Pedersen, Hanne Refsgaard, Lene Alirangis, Johannes Fels, Anita Neutzsky-Wulff, Per Sauerberg
The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes. Insulin doses must be adjusted to ensure blood glucose values within normal range, but matching insulin doses to fluct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f11fc10aa8b4da1245021a1cf15e84
https://doi.org/10.21203/rs.3.rs-2882397/v1
https://doi.org/10.21203/rs.3.rs-2882397/v1
Autor:
MILLE KRONBORG LYHNE, KATHRIN HINZ, ANDREAS VEGGE, JEPPE STURIS, JONAS KILDEGAARD, ULRIK PEDERSEN-BJERGAARD, LISBETH HØIER OLSEN
Publikováno v:
Diabetes. 71
Hypoglycemia is a common adverse effect of insulin treatment in people with diabetes and recurrent episodes can alter counter regulation, ultimately increasing the risk of severe hypoglycemic episodes. The aim of this study was to investigate the eff
Autor:
Anna Katrina Jógvansdóttir Gradel, Jens Lykkesfeldt, Hanne H. F. Refsgaard, Jonas Kildegaard, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:783-794
In humans, food intake and glucose infusion have been reported to increase subcutaneous blood flow. Since local blood flow influences the rate of insulin absorption from the subcutaneous tissue, we hypothesised that an increase in blood glucose level
Autor:
Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharm
Autor:
Johannes Josef Fels, Anne Marie V. Schou-Pedersen, Jonas Kildegaard, Jens Lykkesfeldt, Trine Pagh Ludvigsen, Hanne H. F. Refsgaard, Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 127:278-286
The domestic pig is commonly used as animal model in the pharmaceutical development of new therapeutics for treatment of diabetes. Since a formal definition of hypoglycaemia only exists in humans, the purpose of this study was to assess the counterre
Autor:
Ulrik Pedersen-Bjergaard, Gro Klitgaard Povlsen, Mille K. Lyhne, Lisbeth H. Olsen, Andreas Vegge, Rita Slaaby, Jonas Kildegaard
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Lyhne, M K, Vegge, A, Povlsen, G K, Slaaby, R, Kildegaard, J, Pedersen-Bjergaard, U & Olsen, L H 2021, ' Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes ', Scientific Reports, vol. 11, 5983 . https://doi.org/10.1038/s41598-021-84758-w
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Lyhne, M K, Vegge, A, Povlsen, G K, Slaaby, R, Kildegaard, J, Pedersen-Bjergaard, U & Olsen, L H 2021, ' Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes ', Scientific Reports, vol. 11, 5983 . https://doi.org/10.1038/s41598-021-84758-w
The potentially fatal cardiovascular effects of hypoglycaemia are not well understood and large animal models of the counter-regulatory responses and cardiovascular consequences of insulin-induced hypoglycaemia are needed to understand the mechanisms
Autor:
Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.