Zobrazeno 1 - 10
of 72
pro vyhledávání: '"JON N. RUMBLEY"'
Publikováno v:
Pathogens, Vol 9, Iss 4, p 281 (2020)
In kinetoplastids, the first seven steps of glycolysis are compartmentalized into a glycosome along with parts of other metabolic pathways. This organelle shares a common ancestor with the better-understood eukaryotic peroxisome. Much of our understa
Externí odkaz:
https://doaj.org/article/8319f073c5e34347ba9f96b189c1207d
Autor:
Chinnadurai Mani, Grady L. Nelson, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Conor T. Ronayne, Hithardha Palle, Lucas N. Solano, Jon M Holy, Jon N. Rumbley, Venkatram R. Mereddy
Publikováno v:
Biochemical and Biophysical Research Communications. 562:127-132
A novel nitrogen mustard CBISC has been synthesized and evaluated as an anticancer agent. CBISC has been shown to exhibit enhanced cell proliferation inhibition properties against mutant p53 cell lines colorectal cancer WiDr, pancreatic cancer (MIAPa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0582a924ef6da62c18ccdeb4776fa9a
https://doi.org/10.1016/j.bbrc.2021.05.062
https://doi.org/10.1016/j.bbrc.2021.05.062
Autor:
Conor T. Ronayne, Jon N. Rumbley, Hithardha Palle, Shirisha Jonnalagadda, Lucas N. Solano, Tanner J. Schumacher, Zachary S. Gardner, Venkatram R. Mereddy, Chinnadurai Mani, Sravan K. Jonnalagadda, Grady L. Nelson
Publikováno v:
Bioorganicmedicinal chemistry letters. 52
A series of nitric oxide (NO) donor furoxan conjugates of N, N-dialkylcarboxy coumarins have been synthesized as potential anticancer agents. The synthesized compounds have been tested for their in vitro antiproliferative activities on various cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb33f40f8d7d3c1ff9ceadfbae417816
https://pubmed.ncbi.nlm.nih.gov/34626786
https://pubmed.ncbi.nlm.nih.gov/34626786
Autor:
Tanner J. Schumacher, Hithardha Palle, Jon N. Rumbley, Michael J. Williams, Zachary S. Gardner, Akira Yoshimura, Venkatram R. Mereddy, Chinnadurai Mani, Greeshma P. Kumpati, Conor T. Ronayne
Publikováno v:
Bioorganicmedicinal chemistry letters. 45
Several phosphonium derivatives have been synthesized from Baylis-Hillman (BH) reaction derived allyl bromides and aryl phosphines as mitochondria targeting anticancer agents. In vitro cell proliferation inhibition studies on various solid tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a23eabf96d5ee9a67cf659bb083de7
https://pubmed.ncbi.nlm.nih.gov/34044122
https://pubmed.ncbi.nlm.nih.gov/34044122
Publikováno v:
Pathogens, Vol 9, Iss 281, p 281 (2020)
Pathogens
Volume 9
Issue 4
Pathogens
Volume 9
Issue 4
In kinetoplastids, the first seven steps of glycolysis are compartmentalized into a glycosome along with parts of other metabolic pathways. This organelle shares a common ancestor with the better-understood eukaryotic peroxisome. Much of our understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bdc99e65cf285846454dbdffd435f5
https://www.mdpi.com/2076-0817/9/4/281
https://www.mdpi.com/2076-0817/9/4/281
Autor:
Abigail L. Richie, Omoyemwen A. Obakpolor, Rosine W. Hall, Bryce D. Mieczkowski, Luke D. Wilson, Autumn M. Jones, Jon N. Rumbley, Gabriel T. Fall, Tim L. Kroft
Publikováno v:
Molecular Reproduction and Development. 85:563-578
Fertilization, the fusion of sperm and oocyte to form a zygote, is the first and arguably the most important cell-cell interaction event in an organism's life. Forward and reverse genetic approaches in the nematode Caenorhabditis elegans have identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413f35cc8ac047a9e769195ba8d1689
https://doi.org/10.1002/mrd.22992
https://doi.org/10.1002/mrd.22992
Autor:
Venkatram R. Mereddy, Jon N. Rumbley, Lucas N. Solano, Shirisha Jonnalagadda, Lester R. Drewes, Grady L. Nelson, Teresa A. Rose-Hellekant, Jon M Holy, Conor T. Ronayne, Sravan K. Jonnalagadda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Novel silyl cyanocinnamic acid derivatives have been synthesized and evaluated as potential anticancer agents. In vitro studies reveal that lead derivatives 2a and 2b have enhanced cancer cell proliferation inhibition properties when compared to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d333c5bbdd350a0d6f8a3e95fac7d833
https://doi.org/10.1038/s41598-019-54709-7
https://doi.org/10.1038/s41598-019-54709-7
Autor:
Jon N. Rumbley, Lucas N. Solano, Lester R. Drewes, Venkatram R. Mereddy, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Grady L. Nelson, Jon M Holy, Conor T. Ronayne
Publikováno v:
Oncotarget
Potent and dual monocarboxylate transporter (MCT) 1 and 4 inhibitors have been developed for the first time as potential anticancer agents based on α-cyanocinnamic acid structural template. Candidate inhibitors 1-9 have been evaluated for in vitro c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0641cc450323c1bfb0be171dc992280
https://pubmed.ncbi.nlm.nih.gov/31040927
https://pubmed.ncbi.nlm.nih.gov/31040927
Publikováno v:
Journal of Human Genetics. 58:127-134
Cytochrome c oxidase (COX) of the electron transport system is thought to be the rate-limiting step in cellular respiration and is found mutated in numerous human pathologies. Here, we employ quaternary three-dimensional (3-D) modeling to construct a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fb004b71135ff7ef994125638fc1b1
https://doi.org/10.1038/jhg.2012.144
https://doi.org/10.1038/jhg.2012.144
Publikováno v:
Endocrinology. 150:5153-5162
Organic anion-transporting polypeptide (Oatp) 1c1 is a high-affinity T(4) transporter expressed in brain barrier cells. Oatp1c1 transports a variety of additional ligands including the conjugated sterol estradiol 17beta-glucuronide (E(2)17betaG). Int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b48cc9ccc264b0ea42839af75f9a070
https://doi.org/10.1210/en.2009-0769
https://doi.org/10.1210/en.2009-0769