Zobrazeno 1 - 10
of 121
pro vyhledávání: '"JOHN W. NICHOLS"'
Autor:
Leslie J. Saunders, John W. Nichols
Publikováno v:
Environmental Toxicology and Chemistry. 42:33-45
Methods for extrapolating measured in vitro intrinsic clearance to a whole-body biotransformation rate constant (k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884bf646de08282109c9aa4440b44b86
https://doi.org/10.1002/etc.5503
https://doi.org/10.1002/etc.5503
Publikováno v:
Environmental Toxicology and Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4abfa85293e17c6fdc056968618efaa
https://doi.org/10.1002/etc.5626
https://doi.org/10.1002/etc.5626
Publikováno v:
Environmental Toxicology and Chemistry, 40(11), 3123-3136. Wiley-Blackwell
Biotransformation may substantially reduce the extent to which organic environmental contaminants accumulate in fish. Presently, however, relatively little is known regarding the biotransformation of ionized chemicals, including cationic surfactants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b994b4f1f817fe97d03a224512ea2e
https://doi.org/10.1002/etc.5189
https://doi.org/10.1002/etc.5189
Autor:
Jonathan T. Haselman, John W. Nichols, Kali Z. Mattingly, Michael W. Hornung, Sigmund J. Degitz
Publikováno v:
Mathematical Biosciences. :109021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fda0d557c1e60d581bad8bf8cff8651
https://doi.org/10.1016/j.mbs.2023.109021
https://doi.org/10.1016/j.mbs.2023.109021
Publikováno v:
Environmental toxicology and chemistryREFERENCES.
The extent to which chemicals bioaccumulate in aquatic and terrestrial organisms represents a fundamental consideration for chemicals management efforts intended to protect public health and the environment from pollution and waste. Many chemicals, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8bf568fdf1b23741fbe3771aaa9761
https://pubmed.ncbi.nlm.nih.gov/35920339
https://pubmed.ncbi.nlm.nih.gov/35920339
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036
https://doi.org/10.1093/toxsci/kfaa036
The Eco‐Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals
Autor:
Thorsten Reemtsma, Kellie A. Fay, Rolf Altenburger, Fabian Fischer, Nathan Pollesch, Lawrence P. Burkhard, Chih Lai, Beate I. Escher, Timothy W. Collette, Joel C. Hoffman, David Leuthold, Gerald T. Ankley, Brett R. Blackwell, Jörg Hackermüller, Gerrit Schüürmann, Jon A. Doering, Werner Brack, Anthony L. Schroeder, John W. Nichols, Martin von Bergen, Drew R. Ekman, Dalma Martinovic-Weigelt, Stefan Scholz
Publikováno v:
Environmental toxicology and chemistry 41(1), 30-45 (2022). doi:10.1002/etc.5242
Organisms are exposed to ever‐changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3268dd209cdb51a0780a9a6a5439b0f
http://resolver.sub.uni-goettingen.de/purl?gldocs-11858/9885
http://resolver.sub.uni-goettingen.de/purl?gldocs-11858/9885
Publikováno v:
Environ Toxicol Chem
Environmental contaminants frequently occur as part of a chemical mixture, potentially resulting in competitive inhibition among multiple substrates metabolized by the same enzyme. Trout liver S9 fractions were used to evaluate the biotransformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef80fd25a49360cfe85fa84c7684d7c
https://doi.org/10.1002/etc.4595
https://doi.org/10.1002/etc.4595
Autor:
Annika Mangold-Döring, Chelsea Grimard, Derek Green, Lynn P. Weber, Stephanie Petersen, John W. Nichols, Natacha S. Hogan, Henner Hollert, Markus Brinkmann, Markus Hecker
Publikováno v:
Environ Sci Technol
Environmental Science and Technology, 55(13), 9109-9118
Environmental Science and Technology 55 (2021) 13
Environmental Science and Technology, 55(13), 9109-9118
Environmental Science and Technology 55 (2021) 13
Standardized laboratory tests with a limited number of model species are a key component of chemical risk assessments. These surrogate species cannot represent the entire diversity of native species, but there are practical and ethical objections aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6363570908a83ef67417cdccef81b60
https://pubmed.ncbi.nlm.nih.gov/34165962
https://pubmed.ncbi.nlm.nih.gov/34165962
Designing QSARs for Parameters of High-Throughput Toxicokinetic Models Using Open-Source Descriptors
Autor:
Brandall Ingle, John F. Wambaugh, Daniel E. Dawson, Katherine Phillips, Rogelio Tornero-Velez, John W. Nichols
Publikováno v:
Environ Sci Technol
The intrinsic metabolic clearance rate (Cl(int)) and fraction of chemical unbound in plasma (f(up)) serve as important parameters for high throughput toxicokinetic models, but experimental data are limited for many chemicals. Open-source quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb31e29bc29602bceb7d1bea28dc3005
https://pubmed.ncbi.nlm.nih.gov/34609843
https://pubmed.ncbi.nlm.nih.gov/34609843