Zobrazeno 1 - 10
of 78
pro vyhledávání: '"JOHN R. SILBER"'
Autor:
Siobhan S. Pattwell, Sonali Arora, Patrick J. Cimino, Tatsuya Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, Benjamin G. Hoffstrom, Norman E. Boiani, Hamid Bolouri, Colin E. Correnti, Barbara Oldrini, John R. Silber, Massimo Squatrito, Patrick J. Paddison, Eric C. Holland
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses a
Externí odkaz:
https://doaj.org/article/e76b737ec4c34d949cb32dc9395b4f44
Autor:
Maria C. Elias, Kathleen R. Tozer, John R. Silber, Svetlana Mikheeva, Mei Deng, Richard S. Morrison, Thomas C. Manning, Daniel L. Silbergeld, Carlotta A. Glackin, Thomas A. Reh, Robert C. Rostomily
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 9, Pp 824-837 (2005)
TWIST is a basic helix-loop-helix (bHLH) transcription factor that regulates mesodermal development, promotes tumor cell metastasis, and, in response to cytotoxic stress, enhances cell survival. Our screen for bHLH gene expression in rat C6 glioma re
Externí odkaz:
https://doaj.org/article/386ee8b0398e45d5b8ab06f58ba309db
Autor:
Miqin Zhang, Zachary R. Stephen, John R. Silber, Guanyou Lin, Peter A. Chiarelli, Richard G. Ellenbogen, Forrest M. Kievit, Kui Wang
Publikováno v:
Adv Funct Mater
Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DNA repair p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815f3833ebbd49c2b2eceb94e93dfd77
https://pubmed.ncbi.nlm.nih.gov/33708035
https://pubmed.ncbi.nlm.nih.gov/33708035
Autor:
Patrick J. Cimino, Sonali Arora, Tobias Bonifert, Norman Boiani, Tatsuya Ozawa, Barbara Oldrini, Frank Szulzewsky, Eric C. Holland, Hamid Bolouri, Massimo Squatrito, Siobhan S. Pattwell, Colin Correnti, Patrick J. Paddison, Pia Hoellerbauer, Benjamin G. Hoffstrom, John R. Silber
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Independent scientific achievements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in gliomas. The explorat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e615877ea5faa94eabc826f51c611660
http://europepmc.org/articles/PMC7293284
http://europepmc.org/articles/PMC7293284
Autor:
Forrest M. Kievit, Ariane E. Erickson, Kui Wang, Richard G. Ellenbogen, John R. Silber, Miqin Zhang
Publikováno v:
Advanced Healthcare Materials. 5:3173-3181
The lack of in vitro models that support the growth of glioblastoma (GBM) cancer stem cells (GSCs) that underlie clinical aggressiveness hinders developing new, effective therapies for GBM. While orthotopic patient-derived xenograft models of GBM bes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f4b39f001c9034b63166e97cfc51f6
https://doi.org/10.1002/adhm.201600684
https://doi.org/10.1002/adhm.201600684
Autor:
Kara White Moyes, Richard G. Ellenbogen, Gail H. Deutsch, Courtney A. Crane, Conrad Winter, Luis F. Gonzalez-Cuyar, Shannon A Kreuser, Virginia Hoglund, Michael Carleton, Amira Davis, Randi Simmons, Darren Locke, Nicole A P Lieberman, John R. Silber, Stephanie Franco, Kristen Haberthur, Debra G. Gilbertson
Publikováno v:
Oncoimmunology
OncoImmunology, Vol 7, Iss 11 (2018)
OncoImmunology, Vol 7, Iss 11 (2018)
Efforts to reduce immunosuppression in the solid tumor microenvironment by blocking the recruitment or polarization of tumor associated macrophages (TAM), or myeloid derived suppressor cells (MDSCs), have gained momentum in recent years. Expanding ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c340920efc84b086fb1fdeb3f30683f1
http://europepmc.org/articles/PMC6204983
http://europepmc.org/articles/PMC6204983
Publikováno v:
Advanced Healthcare Materials. 4:2719-2726
Human tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is an attractive cancer therapeutic because of its ability to induce apoptosis in tumor cells while having a negligible effect on normal cells. However, the short serum half-lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f48133a7dd0fb6020c5ab5aaa28b68c
https://doi.org/10.1002/adhm.201500563
https://doi.org/10.1002/adhm.201500563
Autor:
A. Blank, Marc C. Chamberlain, Robert C. Rostomily, John Y.-S. Chen, John R. Silber, Daniel L. Silbergeld, Douglas D. Kolstoe, Michael S. Bobola, Mohammad Alnoor
Publikováno v:
BBA Clinical. 3:1-10
BackgroundCpG methylation in the O6-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response refle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca4f004e2abcb0f25014e7e10a1f17f