Výsledky vyhledávání - "JOHN L. EMMERSON"

Subchronic toxicity, metabolism, and pharmacokinetics of the aminobenzamide anticonvulsant ameltolide (LY201116) in rhesus monkeys

Autor: J. R. Shoufler, J. A. Engelhardt, C. J. Parli, John L. Emmerson, J. D. Leander, P. M. Kovach

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 19(2)

Studies were undertaken to define the subchronic toxicologic profile of ameltolide, an aminobenzamide anticonvulsant, in young adult rhesus monkeys. Daily doses of ameltolide, dissolved in 10% aqueous acacia, were administered orally via nasogastric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432a9aff10838b6b350332ddaba84e36
https://pubmed.ncbi.nlm.nih.gov/1516775

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Oncogenicity study of trifluralin in B6C3F1 mice

Autor: P.C. Francis, N.V. Owen, John L. Emmerson, E. R. Adams

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 29(8)

B6C3F1 mice were maintained for 24 months on diets containing 0, 563, 2250 or 4500 ppm trifluralin. These dietary concentrations corresponded to daily doses of approximately 70, 285 or 570 mg/kg body weight, respectively. The control group contained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2f83f13f2ca9cbbad8550806d61228
https://pubmed.ncbi.nlm.nih.gov/1894221

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Preclinical Toxicology Studies with Nizatidine, A New H2-Receptor Antagonist: Acute, Subchronic, and Chronic Toxicity Evaluations

Autor: KAREN S. PROBST, GARY L. HIGDON, LAWRENCE F. FISHER, JOHN P. MCGRATH, ELIZABETH R. ADAMS, JOHN L. EMMERSON

Publikováno v: Toxicological Sciences. 13:778-792

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f118cc90dcf8d4898035b8a9f6b0f5a
https://doi.org/10.1093/toxsci/13.4.778

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Microsomal drug-metabolizing enzyme activity in rats given α-(2,4-dichlorophenyl)-α-phenyl-5-pyrimidinemethanol for periods of 14 days to 2 years

Autor: N.R. Bernhard, John L. Emmerson, H.M. Worth, D.G. Hoffman

Publikováno v: Toxicology and Applied Pharmacology. 35:413-421

The dose-response relationships for stimulation of hepatic drug-metabolizing enzymes were studied in rats given α-(2,4-dichlorophenyl)-α-phenyl-5-pyrimidinemethanol (EL-273) in the diet for periods of 2 weeks-2 years. The dietary concentrations ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c7f2d6a963e88c208b868a459215b
https://doi.org/10.1016/0041-008x(76)90064-8

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Stimulation of hepatic drug-metabolizing enzymes by chlorophenothane (DDT); The relationship to liver enlargement and hepatotoxicity in the rat

Autor: D.G. Hoffman, H.M. Worth, Robert C. Anderson, John L. Emmerson

Publikováno v: Toxicology and Applied Pharmacology. 16:171-178

To study the relationship between induction of drug-metabolizing enzymes, liver enlargement and hepatotoxicity, we have administered DDT [1,1,1-trichloro-2,2-bis( p -chlorophenyl)ethane] to weanling male rats for 14 days. While administration of DDT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e0dff7ee3972eedea03a62281024b0
https://doi.org/10.1016/0041-008x(70)90173-0

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Acute toxicity of propoxyphene salts

Autor: Robert C. Anderson, John L. Emmerson, W.R. Gibson

Publikováno v: Toxicology and Applied Pharmacology. 19:445-451

The acute toxicity of oral and parenteral doses of propoxyphene HCl was studied in laboratory animals. Large iv, im, or ip doses of propoxyphene HCl produced clonic and tonic convulsions in mice, rats, and dogs. Death from oral doses of propoxyphene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbc8811a6c32b693113b5ca6c6a0b54
https://doi.org/10.1016/0041-008x(71)90003-2

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Preclinical toxicology studies with tobramycin

Autor: W.R. Gibson, R. Nickander, John S. Welles, N.V. Owen, Robert C. Anderson, John L. Emmerson

Publikováno v: Toxicology and Applied Pharmacology. 25:398-409

Tobramycin, an aminoglycoside antibiotic, has been administered to mice, rats, cats and dogs for toxicologic evaluation. The sc LD50 values in mice and rats were 441 and 969 mg/kg, respectively. Deaths were preceded by CNS depression and occurred wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156d20574e320fae822e3f181cb2bca9
https://doi.org/10.1016/0041-008x(73)90313-x

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