Zobrazeno 1 - 10
of 637
pro vyhledávání: '"JOHN E. SHIVELY"'
Autor:
Dennis Awuah, Lin Li, Lindsay Williams, Ryan Urak, Maciej Kujawski, Stephen J. Forman, John E. Shively, Xiuli Wang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Bispecific T cell engaging antibodies (bsAbs) have emerged as novel and powerful therapeutic agents for redirecting T cells towards antigen-specific tumor killing. The cell surface glycoprotein and SLAM family member, CS1, exhibits stable an
Externí odkaz:
https://doaj.org/article/d8b4c88f6fe24aa3a0c46cae4a0598c2
Autor:
Vikram Adhikarla, Dennis Awuah, Enrico Caserta, Megan Minnix, Maxim Kuznetsov, Amrita Krishnan, Jefferey Y. C. Wong, John E. Shively, Xiuli Wang, Flavia Pichiorri, Russell C. Rockne
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCancer combination treatments involving immunotherapies with targeted radiation therapy are at the forefront of treating cancers. However, dosing and scheduling of these therapies pose a challenge. Mathematical models provide a unique way
Externí odkaz:
https://doaj.org/article/96e8a554e31747d194761070638678f4
Autor:
Lindsay Williams, Lin Li, Paul J. Yazaki, Patty Wong, Teresa Hong, Erasmus K. Poku, Susanta Hui, Hemendra Ghimire, John E. Shively, Maciej Kujawski
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Background The potent immune effects of interleukin‐2 (IL‐2) for cancer therapy can be increased by genetic fusion of IL‐2 to the Fc domain of an antibody (IL‐2‐Fc) or tumor targeted by genetic fusion to a whole antibody known as a
Externí odkaz:
https://doaj.org/article/5d59608a2bfc41f3848415e9d3c06ce0
Development and characterization of DIA 12.3, a fully human intact anti-CEACAM1 monoclonal antibody.
Autor:
Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0295345 (2024)
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1), a homotypic cell adhesion molecule glycoprotein with apical expression on normal epithelial cells and activated lymphocytes, is overexpressed on many tumors and acts as an inhibitory recept
Externí odkaz:
https://doaj.org/article/b51ad4ff63384ac8a4df3e97495290ac
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 11-27 (2022)
Recent studies have identified long non-coding RNAs (lncRNAs) as potential regulators of adipogenesis. In this study, we have characterized a lncRNA, LIPE-AS1, that spans genes CEACAM1 to LIPE in man with conservation of genomic organization and tiss
Externí odkaz:
https://doaj.org/article/831330b5d4904bf1a0c51aca96a322f6
Autor:
Jiangling Peng, Wei Tang, Jeffrey Rawson, Lynn Miao, Nelson Gonzalez, Runkai Yin, Jiaqi Chen, Melinda Ji, Zhixuan Li, Anna Gao, Andy Z. Wu, John E. Shively, Fouad Kandeel, Junfeng Li
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1480 (2023)
Recently, a G-protein coupled receptor 44 (GPR44) was discovered to play a significant role in the process of inflammation-related diseases, including cancer and diabetes. However, the precise role of GPR44 has yet to be fully elucidated. Currently,
Externí odkaz:
https://doaj.org/article/9651c4ece46445dc974b3f96b53e9d6d
Autor:
Runkai Yin, Kelly X. Huang, Lina A. Huang, Melinda Ji, Hanyi Zhao, Kathy Li, Anna Gao, Jiaqi Chen, Zhixuan Li, Tianxiong Liu, John E. Shively, Fouad Kandeel, Junfeng Li
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1203 (2023)
Recently, growing evidence of the relationship between G-protein coupled receptor 44 (GPR44) and the inflammation-cancer system has garnered tremendous interest, while the exact role of GPR44 has not been fully elucidated. Currently, there is a stron
Externí odkaz:
https://doaj.org/article/0de8d5cff105418fab4ef31ee81fa826
Publikováno v:
Cancer Medicine, Vol 9, Iss 13, Pp 4756-4767 (2020)
Abstract Introduction Ovarian cancer has only a 17% 5‐year survival rate in patients diagnosed with late stage disease. Tumor‐associated glycoprotein‐72 (TAG72), expressed in 88% of all stages of ovarian cancer, is an excellent candidate for an
Externí odkaz:
https://doaj.org/article/39c08780ebd94cffa6cfb8035f48bfb8
Autor:
Junfeng Li, Weidong Hu, Jiangling Peng, Patty Wong, Fouad Kandeel, Tove Olafsen, John E. Shively
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1577 (2022)
The world-wide high incidence of non-alcoholic fatty liver disease (NAFLD) is of concern for its progression to insulin resistance, steatohepatitis and cardiovascular disease (CVD). The increased uptake of fatty acids in critical organs plays a major
Externí odkaz:
https://doaj.org/article/3f9c736a80a54457bdf7222f4732c34c
Autor:
Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki, John E. Shively
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES requires proper protein
Externí odkaz:
https://doaj.org/article/ac867d27e03b48d49a75f75d86b0177f