Výsledky vyhledávání - "JOHN CONNELLY"

Akademický článek

Aufsätze / Articles. Vernichtungskrieg und Imperialer Nationalstaat: Russland und Deutschland im Vergleich

Autor: John Connelly

Publikováno v: Totalitarismus und Demokratie, Vol 21, Iss 1, Pp 13-36 (2024)

Abstract Ukraine is witness to an unusual kind of war, a Vernichtungskrieg, a war of wanton destruction. In the modern age there are few wars of this type, the most infamous being the aggression of Nazi Germany. The scale of destruction is now very d

Externí odkaz: https://doaj.org/article/a5e957040043495889b272c0d20f4136

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Akademický článek

Metagenomic DNA sequencing to quantify Mycobacterium tuberculosis DNA and diagnose tuberculosis

Autor: Adrienne Chang, Omary Mzava, Liz-Audrey Kounatse Djomnang, Joan Sesing Lenz, Philip Burnham, Peter Kaplinsky, Alfred Andama, John Connelly, Christine M. Bachman, Adithya Cattamanchi, Amy Steadman, Iwijn De Vlaminck

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract Tuberculosis (TB) remains a significant cause of mortality worldwide. Metagenomic next-generation sequencing has the potential to reveal biomarkers of active disease, identify coinfection, and improve detection for sputum-scarce or culture-n

Externí odkaz: https://doaj.org/article/28d3eaa4844b454997e0d52a41374b20

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Akademický článek

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

Autor: Antonio Martin-Bastida, Roberta J. Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C. Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R. Crichton, David T. Dexter

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Parkinson’s disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD

Externí odkaz: https://doaj.org/article/447847d27a3f44eea2861e4c6d11074c

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Akademický článek

Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue

Autor: Scott A. Sands, Regis Leung-Toung, Yingsheng Wang, John Connelly, Steven M. LeVine

Publikováno v: ASN Neuro, Vol 8 (2016)

Histochemical methods of detecting iron in the rodent brain result mainly in the labeling of oligodendrocytes, but as all cells utilize iron, this observation suggests that much of the iron in the central nervous system goes undetected. Paraffin embe

Externí odkaz: https://doaj.org/article/b5e3d7c849cc441b9fa46d96a3a48ceb

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Akademický článek

Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial.

Autor: Deepti Saxena, Michael Spino, Fernando Tricta, John Connelly, Bernadette M Cracchiolo, Axel-Rainer Hanauske, Darlene D'Alliessi Gandolfi, Michael B Mathews, Jonathan Karn, Bart Holland, Myung Hee Park, Tsafi Pe'ery, Paul E Palumbo, Hartmut M Hanauske-Abel

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154842 (2016)

UNLABELLED:Antiretrovirals suppress HIV-1 production yet spare the sites of HIV-1 production, the HIV-1 DNA-harboring cells that evade immune detection and enable viral resistance on-drug and viral rebound off-drug. Therapeutic ablation of pathogenic

Externí odkaz: https://doaj.org/article/e17e5bea35ab4969b437207695534e81

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Akademický článek

Drug-induced reactivation of apoptosis abrogates HIV-1 infection.

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74414 (2013)

HIV-1 blocks apoptosis, programmed cell death, an innate defense of cells against viral invasion. However, apoptosis can be selectively reactivated in HIV-infected cells by chemical agents that interfere with HIV-1 gene expression. We studied two glo

Externí odkaz: https://doaj.org/article/6c8d6c50e71847d2ba0749f5c2b0cea3

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Elektronická kniha

From Enemy to Brother : The Revolution in Catholic Teaching on the Jews, 1933–1965

Autor: John Connelly

In 1965 the Second Vatican Council declared that God loves the Jews. Before that, the Church had taught for centuries that Jews were cursed by God and, in the 1940s, mostly kept silent as Jews were slaughtered by the Nazis. How did an institution who

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