Zobrazeno 1 - 10
of 352
pro vyhledávání: '"JOHN C RODER"'
Autor:
Greer S Kirshenbaum, Neil Dawson, Jonathan G L Mullins, Tom H Johnston, Mark J Drinkhill, Ian J Edwards, Susan H Fox, Judith A Pratt, Jonathan M Brotchie, John C Roder, Steven J Clapcote
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60141 (2013)
Missense mutations in ATP1A3 encoding Na(+),K(+)-ATPase α3 have been identified as the primary cause of alternating hemiplegia of childhood (AHC), a motor disorder with onset typically before the age of 6 months. Affected children tend to be of shor
Externí odkaz:
https://doaj.org/article/f77497bbfa82468199347510a9502a64
Autor:
Tatiana V Lipina, Fahmida Nipa Haque, Alexander McGirr, Paul C Boutros, Thorsten Berger, Tak W Mak, John C Roder, Albert H C Wong
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51562 (2012)
Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders. Disc1-L100P mutant mice show behaviors relevant to schizoph
Externí odkaz:
https://doaj.org/article/e411ab5160c34deda3fa15724beb453e
Autor:
David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e41 (2009)
The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, U
Externí odkaz:
https://doaj.org/article/3b93d0508888458dabaff426a1a4130a
Autor:
John C. Roder, Ping Su, Rafael K. Varaschin, Albert H.C. Wong, Bernard Le Foll, Louis-Eric Trudeau, Caleb J. Browne, Fang Liu, Enoch Ng, Olaf Pongs, Joanna Hermainski
Publikováno v:
Behavioural Brain Research. 301:213-225
Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad706d5bd9cef24cde1569c190d9f3f
https://doi.org/10.1016/j.bbr.2015.12.037
https://doi.org/10.1016/j.bbr.2015.12.037
Autor:
Bryan E. Snow, Carol A. Barnes, Frank P. Houston, Sanjeev Mariathasan, David P. Siderovski, Takehiko Sasaki, Ian Q. Whishaw, Goichi Matsumoto, Donglin Bai, Antonio J. Oliveira-dos-Santos, Pamela S. Ohashi, John C. Roder, Andrew Wakeham, Josef M. Penninger
Publikováno v:
Proc Natl Acad Sci U S A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4414f5dbd37d63d83ece7e68125a4c83
https://doi.org/10.1073/pnas.2018014117
https://doi.org/10.1073/pnas.2018014117
Autor:
Ariel Avila, Kathleen Trought, Albert H.C. Wong, Enoch Ng, Ho Suk Mun, Graham L. Collingridge, Panayiotis Servinis, John Georgiou, John C. Roder, Meggie Hodgson
Publikováno v:
Behavioural Brain Research. 381:112420
Neuronal calcium sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal calcium sensor-1 has been implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43261f8f7c419ff9c22ed231ee95c49e
https://doi.org/10.1016/j.bbr.2019.112420
https://doi.org/10.1016/j.bbr.2019.112420
Autor:
Min Wang, Albert H.C. Wong, Stephen S. G. Ferguson, John C. Roder, Shupeng Li, Ping Su, Tatiana V. Lipina, Paul J. Fletcher, Hailong Zhang, Sheng Chen, Terence K. Y. Lai, José N. Nobrega, Dongxu Zhai, Fang Liu, Frankie H. F. Lee
Publikováno v:
Neuron. 84(6):1302-1316
Summary Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these drugs have serious side effects such as extrapyramidal symptoms (EPS) and diabetes. Ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599c994a2c4a789237b497ccbd0b8c87
Autor:
John C. Roder, Tatiana V. Lipina
Publikováno v:
Neuroscience & Biobehavioral Reviews. 45:271-294
Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses. Notably, a number of genes encoding proteins interacting with DISC1 are also considered to be relevant risk facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e3600d7fa8defddfa56b76c07b12a9
https://doi.org/10.1016/j.neubiorev.2014.07.001
https://doi.org/10.1016/j.neubiorev.2014.07.001
Autor:
John C. Roder, Mustafa Khan, Thomas T. Luyben, Christian R. Goldsmith, John Georgiou, Zhen Huang, Kenichi Okamoto, Stephen J. Lippard
Publikováno v:
Proceedings of the National Academy of Sciences. 111:6786-6791
Mossy fiber termini in the hippocampus accumulate Zn(2+), which is released with glutamate from synaptic vesicles upon neural excitation. Understanding the spatiotemporal regulation of mobile Zn(2+) at the synaptic level is challenging owing to the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6087e08c683e78c8809a59a47944b14
https://doi.org/10.1073/pnas.1405154111
https://doi.org/10.1073/pnas.1405154111
Publikováno v:
Neuroscience & Biobehavioral Reviews. 37:896-910
Schizophrenia and substance use disorders (SUD) often occur together, yet it is unclear why this is the case or how best to manage dual diagnosis. Rodent models are well suited to study how genes and environment interact to impact neurodevelopment, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d901b0f9b62d7e03537dfea0210ae0d
https://doi.org/10.1016/j.neubiorev.2013.03.025
https://doi.org/10.1016/j.neubiorev.2013.03.025