Zobrazeno 1 - 10
of 125
pro vyhledávání: '"JOHN A. EDGAR"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Researchers at Newcastle University have discovered a mechanism by which earthquakes create bursts of hydrogen peroxide and oxygen in hot underground fractures. These may have played a vital role in the early evolution and origin of life on Earth.
Externí odkaz:
https://doaj.org/article/77bd2ea00f1748869971d693b410b332
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The generation of T-cells from stem cells in vitro could provide an alternative source of cells for immunotherapies. T-cell development from hematopoietic stem and progenitor cells (HSPCs) is tightly regulated through Notch pathway activatio
Externí odkaz:
https://doaj.org/article/71cda5e4d6d64e01a7fc4d2753c6d8d5
Autor:
Lori I. Robins, Erika K. Keim, Deborah B. Robins, John S. Edgar, John S. Meschke, Philip R. Gafken, Jeffrey F. Williams
Publikováno v:
ACS Omega, Vol 6, Iss 51, Pp 35593-35599 (2021)
Externí odkaz:
https://doaj.org/article/7c6dc9ca327b4ce585bd8fc431a04f61
Autor:
Laura N Stankiewicz, Kevin Salim, Emily A Flaschner, Yu Xin Wang, John M Edgar, Bruce ZB Lin, Grace C Bingham, Matthew C Major, Ross D Jones, Helen M Blau, Elizabeth J Rideout, Megan K Levings, Peter W Zandstra, Fabio MV Rossi
Publikováno v:
bioRxiv
SummaryWithin the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7bca0c46114847f2a5ad4602946ecd
https://doi.org/10.1101/2023.04.13.536804
https://doi.org/10.1101/2023.04.13.536804
Intro Kerogen is insoluble, macromolecular organic matter in sedimentary rocks. Kerogen is highly abundant on Earth, making this subsurface carbon reservoir larger than any single surface carbon reservoir. Based on the origin of the organic matter, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::198fa34ba096cfd988ebb0c0c71ac60a
https://doi.org/10.5194/epsc2022-1108
https://doi.org/10.5194/epsc2022-1108
Autor:
Yale S. Michaels, John M. Edgar, Matthew C. Major, Elizabeth L. Castle, Carla Zimmerman, Ting Yin, Andrew Hagner, Charles Lau, Han Hsuan Hsu, M. Iliana Ibañez-Rios, Lauren J. Durland, David J. H. F. Knapp, Peter W. Zandstra
Publikováno v:
Science Advances. 8
T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the potential to provide a renewable source of T cells, but differentiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc04440b7a020a348127528a8b9d7eff
https://doi.org/10.1126/sciadv.abn5522
https://doi.org/10.1126/sciadv.abn5522
Publikováno v:
Journal of Clinical Immunology. 43:548-549
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b6bdca12848710fc3ccbd938b84dc4
https://doi.org/10.1007/s10875-022-01424-0
https://doi.org/10.1007/s10875-022-01424-0
Publikováno v:
Chemical research in toxicology. 35(3)
Sporadic motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), can be caused by spontaneous genetic mutations. However, many sporadic cases of ALS and other debilitating neurodegenerative diseases (NDDs) are believed to be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374b1d9f6035c7008c9a95e28e490ce3
https://pubmed.ncbi.nlm.nih.gov/35238548
https://pubmed.ncbi.nlm.nih.gov/35238548
Autor:
John A. Edgar
Publikováno v:
Journal of Theoretical Biology. 476:62-73
The lifeless earth was formed around 4.5 billion years ago and the first anaerobic unicellular “organisms” may have appeared half a billion years later. Despite subsequent prokaryotes (bacteria and archaea) evolving quite complex biochemistry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9548d9bb5f36fefb1339e9b9928dbc5
https://doi.org/10.1016/j.jtbi.2019.06.001
https://doi.org/10.1016/j.jtbi.2019.06.001
Autor:
Thomas Hofmann, Russell J. Molyneux, John A. Edgar, Laura L. McConnell, Peter Schieberle, Steven M. Colegate, John J. Beck, John Gilbert, William Gaffield
Publikováno v:
Pure and Applied Chemistry. 91:1417-1437
Isolation of endogenous constituents of foods is generally performed in order to elucidate the biological activity of individual compounds and their role with respect to factors such as organoleptic qualities, health and nutritional benefits, plant p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5a6b4c1802be7f72411f4b03c41c89
https://doi.org/10.1515/pac-2017-1204
https://doi.org/10.1515/pac-2017-1204