Zobrazeno 1 - 10
of 297
pro vyhledávání: '"JOEL SMITH"'
Autor:
Oliver Heath, Brooke Allender, Joel Smith, Elena Savva, Lucy Spencer, Elizabeth G. Bannister, Natasha J. Brown, Maureen S. Evans, Sharmila Kiss, Thomas H. Rozen, Joy Yaplito‐Lee
Publikováno v:
JIMD Reports, Vol 65, Iss 4, Pp 239-248 (2024)
Abstract Familial chylomicronemia syndrome (FCS) is a rare disorder of triglyceride (TG) metabolism caused by loss of function variants in one of five known canonical genes involved in chylomicron lipolysis and clearance—LPL, APOC2, APOA5, LMF1, an
Externí odkaz:
https://doaj.org/article/e0ae9d872ca24a4b99aab791f4a1c2dc
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Publikováno v:
Thyroid Research, Vol 15, Iss 1, Pp 1-10 (2022)
Abstract Introduction Sporadic medullary thyroid cancer accounts for 75% of all medullary thyroid cancers and presents at a more advanced disease stage than its hereditary counterparts. Yet there is little evidence to support risk stratification of p
Externí odkaz:
https://doaj.org/article/6f5391d6f8c64bdbb6bbec99a7e1a802
Autor:
Alane B O’Connor, Joel Smith, Liam M O’Brien, Kaitlyn Lamarche, Nadine Byers, Stephanie D Nichols
Publikováno v:
Substance Abuse: Research and Treatment, Vol 16 (2022)
Aim: Little is known about whether pain can be effectively managed in pregnant women with opioid use disorder (OUD) during delivery hospitalization, particularly those undergoing surgery and taking buprenorphine as medication for OUD (MOUD). To addre
Externí odkaz:
https://doaj.org/article/d8726e6fca754b4cbdfde554d0954821
Autor:
Chrissy Bolton, Yifan Chen, Rachel Hawthorne, Ianthe R. M. Schepel, Elinor Harriss, Silke C. Hofmann, Spencer Ellis, Alexander Clarke, Helena Wace, Blanca Martin, Joel Smith
Publikováno v:
Drugs in R&D, Vol 20, Iss 4, Pp 319-330 (2020)
Abstract Background Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but there are limited data
Externí odkaz:
https://doaj.org/article/675cad814f1e48b8a7f8324f8f8d3305
Autor:
David A. Jones, Joel Smith, Xue W. Mei, Maria A. Hawkins, Tim Maughan, Frank van den Heuvel, Thomas Mee, Karen Kirkby, Norman Kirkby, Alastair Gray
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 20, Iss , Pp 19-26 (2020)
Background and purpose: With high treatment costs and limited capacity, decisions on which adult patients to treat with proton beam therapy (PBT) must be based on the relative value compared to the current standard of care. Cost-utility analyses (CUA
Externí odkaz:
https://doaj.org/article/5927014985b94791a9996a1e2914bae1
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231241 (2020)
Traditionally, subgroup analyses are used to assess whether patient characteristics moderate treatment effectiveness with general disregard for issues of multiplicity. Using data from The Action for Health in Diabetes (Look AHEAD) trial in the United
Externí odkaz:
https://doaj.org/article/ab52ac580a594fc7987fb9baf78723c3
Autor:
Thaddeus T Gbem, Mario Waespy, Bettina Hesse, Frank Dietz, Joel Smith, Gloria D Chechet, Jonathan A Nok, Sørge Kelm
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2549 (2013)
Trans-sialidases are key enzymes in the life cycle of African trypanosomes in both, mammalian host and insect vector and have been associated with the disease trypanosomiasis, namely sleeping sickness and nagana. Besides the previously reported TconT
Externí odkaz:
https://doaj.org/article/d82a03f96b5d4150b42c0eeff23a4e8a
Autor:
Matthew A. Barsalou, Joel Smith
This book was written to provide guidance for those who need to apply statistical methods for practical use. While the book provides detailed guidance on the use of Minitab for calculation, simply entering data into a software program is not sufficie
Autor:
Catharine Abell, Joel Smith
The Expression of Emotion collects cutting-edge essays on emotional expression written by leading philosophers, psychologists, and legal theorists. It highlights areas of interdisciplinary research interest, including facial expression, expressive ac