Zobrazeno 1 - 10
of 1 345
pro vyhledávání: '"JOAO A. PAULO"'
Autor:
Daniel C. Scott, Sagar Chittori, Nicholas Purser, Moeko T. King, Samuel A. Maiwald, Kelly Churion, Amanda Nourse, Chan Lee, Joao A. Paulo, Darcie J. Miller, Stephen J. Elledge, J. Wade Harper, Gary Kleiger, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Specificity of the ubiquitin-proteasome system depends on E3 ligase-substrate interactions. Many such pairings depend on E3 ligases binding to peptide-like sequences - termed N- or C-degrons - at the termini of substrates. However, our knowl
Externí odkaz:
https://doaj.org/article/1085cb553def4be2ba1ef9f68687d295
Autor:
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-su
Externí odkaz:
https://doaj.org/article/6c50c513c918469eaf4c94f0f0e0d58b
Autor:
Yoko Shibata, Emily E. Mazur, Buyan Pan, Joao A. Paulo, Steven P. Gygi, Suyog Chavan, L. Sebastian Alexis Valerio, Jiuchun Zhang, Tom A. Rapoport
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of four proteins in mammals (REEP1-4), is less abundant and lack a N-termi
Externí odkaz:
https://doaj.org/article/65a6f1af4e0d4c628c2c71d3e810cabe
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Autor:
Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham, Vivek Gupta
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability. Glaucoma, a
Externí odkaz:
https://doaj.org/article/d7db4e6a717b435a9af6adcbde678a30
Autor:
Ole Vidhammer Bjørnstad, Manuel Carrasco, Kenneth Finne, Vandana Ardawatia, Ingeborg Winge, Cecilie Askeland, Jarle B. Arnes, Gøril Knutsvik, Dimitrios Kleftogiannis, Joao A. Paulo, Lars A. Akslen, Heidrun Vethe
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105325- (2024)
Summary: Background: Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is emerging. A recent study in prostate
Externí odkaz:
https://doaj.org/article/b4465446dd87464692b1cff514237eab
Autor:
Pattarawan Pattamaprapanont, Eileen M. Cooney, Tara L. MacDonald, Joao A. Paulo, Hui Pan, Jonathan M. Dreyfuss, Sarah J. Lessard
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100159- (2024)
Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary d
Externí odkaz:
https://doaj.org/article/37f49428b788458294966f8f3bd9d9c4
Autor:
Morteza Abyadeh, Shahab Mirshahvaladi, Sara Assar Kashani, Joao A. Paulo, Ardeshir Amirkhani, Fatemeh Mehryab, Homeyra Seydi, Niloufar Moradpour, Sheyda Jodeiryjabarzade, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 6, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are secreted by cells and play a critical role in cell‐to‐cell communication. Despite the promising reports regarding their diagnostic and therapeutic potentia
Externí odkaz:
https://doaj.org/article/f926957ff40f4c09bd17ec6d302d0daa
Autor:
Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O. Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzaei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 6, Pp 1262-1276 (2024)
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two pr
Externí odkaz:
https://doaj.org/article/f8fe9e44ce7e49208ce6a071ba24f39c
Autor:
Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins
Externí odkaz:
https://doaj.org/article/c5eb5a2f13b44fa3a6446d25a2216f50