Zobrazeno 1 - 8
of 8
pro vyhledávání: '"JOANA ALMACA"'
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine an
Externí odkaz:
https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
Autor:
Luciana Mateus Gonçalves, Joana Almaça
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine cells with their vascular system. Islets receive blood through f
Externí odkaz:
https://doaj.org/article/08dd767ca05740d5951064e0c4d0fc6e
Autor:
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in b
Externí odkaz:
https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d
Autor:
SILVIA ALVAREZ-CUBELA, DAGMAR KLEIN, CHARLES G. ALVER, MIRZA MUHAMMAD FAHD QADIR, LUCIANA MATEUS GONCALVES, FARHAN QURESHI, JOANA ALMACA, CHRISTOPHER FRAKER, ALEJANDRO CAICEDO, ALBERTO PUGLIESE, CAMILLO RICORDI, ELISA OLTRA, ASHUTOSH G. AGARWAL, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA
Publikováno v:
Diabetes. 71
Introduction: The study of pancreatic regeneration would benefit greatly from the design and validation of robust human-based models. Human Pancreatic Slices (HPSs) are thin organotypic sections of live pancreatic tissue. The sectioning method preser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab35f62fc17727fe8d85f4a813d83d7
https://doi.org/10.2337/db22-251-lb
https://doi.org/10.2337/db22-251-lb
Autor:
Manuel Blandino-Rosano, Ruy Andrade Louzada, Joao Pedro Werneck-De-Castro, Camila Lubaczeuski, Joana Almaça, Markus A. Rüegg, Michael N. Hall, Gil Leibowitz, Ernesto Bernal-Mizrachi
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101769- (2023)
Objective: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin
Externí odkaz:
https://doaj.org/article/492f65d1d70946308c8773653d0f3eef
Autor:
Luciana Mateus Gonçalves, Mirza Muhammad Fahd Qadir, Maria Boulina, Madina Makhmutova, Elizabeth Pereira, Joana Almaça
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112913- (2023)
Summary: Pancreatic islets are endocrine organs that depend on their microvasculature to function. Along with endothelial cells, pericytes comprise the islet microvascular network. These mural cells are crucial for microvascular stability and functio
Externí odkaz:
https://doaj.org/article/4e192eb5f2dc482c9e6f9eb1a20b3cc0
Autor:
Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3281-3291 (2016)
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet. It is still unclear whether serotonin is relevant for regular islet physiology a
Externí odkaz:
https://doaj.org/article/ee0a0767afc34e4abac748b8dcd8a23f