Mechanism of JNK action in oxidative stress-enhanced gut injury by Clostridium perfringens type A infection.

Autor: Lin H; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Liu Y; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Zhang L; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Yang F; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Liu Y; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Li Y; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Liu Y; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Qiu Z; College of Veterinary Medicine, Southwest University, Chongqing 402460, China., Chen H; Chongqing General Station of Animal Husbandry Technology Promotion, Chongqing 401120, China., He D; Chongqing General Station of Animal Husbandry Technology Promotion, Chongqing 401120, China., Zhu Y; Chongqing General Station of Animal Husbandry Technology Promotion, Chongqing 401120, China., Gan L; College of Veterinary Medicine, Southwest University, Chongqing 402460, China. Electronic address: gl9089@swu.edu.cn.

Publikováno v: Veterinary microbiology [Vet Microbiol] 2024 Nov; Vol. 298, pp. 110223. Date of Electronic Publication: 2024 Aug 24.

Characterization of c-Jun N-terminal kinase (JNK) gene reveals involvement of immune defense against Vibrio splendidus infection in Apostichopus japonicus.

Autor: Tao W; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China., Xu W; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China., Li X; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China., Zhang X; Yantai Marine Economic Research Institute, Yantai, 265503, PR China. Electronic address: xmzhang50542@126.com., Li C; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, PR China., Guo M; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China. Electronic address: guoming@nbu.edu.cn.

Publikováno v: Fish & shellfish immunology [Fish Shellfish Immunol] 2024 Oct; Vol. 153, pp. 109804. Date of Electronic Publication: 2024 Aug 03.

Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads.

Autor: Bálint D; Organocatalysis Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary.; Hevesy György PhD School of Chemistry, Eötvös Loránd University, 1117, Budapest, Hungary., Póti ÁL; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary.; Doctoral School of Biology, Eötvös Loránd University, 1117, Budapest, Hungary., Alexa A; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Sok P; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Albert K; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Torda L; Organocatalysis Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Földesi-Nagy D; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Csókás D; Theoretical Chemistry Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Turczel G; NMR Research Laboratory, Centre for Structural Science, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Imre T; MS Metabolomic Research Laboratory, Centre for Structural Science, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Szarka E; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Fekete F; Metabolic Drug-interactions Research Group, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Bento I; European Molecular Biology Laboratory, EMBL, Hamburg, Germany., Bojtár M; Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Palkó R; Organocatalysis Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Szabó P; MS Metabolomic Research Laboratory, Centre for Structural Science, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Monostory K; Metabolic Drug-interactions Research Group, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Pápai I; Theoretical Chemistry Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary., Soós T; Organocatalysis Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary. soos.tibor@ttk.hu., Reményi A; Biomolecular Interaction Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, 1117, Budapest, Hungary. remenyi.attila@ttk.hu.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 04; Vol. 15 (1), pp. 8606. Date of Electronic Publication: 2024 Oct 04.

Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor.

Autor: Liu X; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Cheng LT; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Ye QR; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Gao HC; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China., Zhu JW; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Zhao K; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Liu HM; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China., Wang YJ; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Alinejad T; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Zhang XH; Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: wzzhangxiuhua@126.com., Chen GZ; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: gaozhichen@wmu.edu.cn.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117172. Date of Electronic Publication: 2024 Aug 11.

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy.

Autor: Zhu H; Department of Gynaecology, the First Affiliated Hospital, Zhejiang Univerisity School of Medicine, Hangzhou, 310009, China. zhuhb@zju.edu.cn., Luo H; Department of Pharmacy, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China., Wu X; Department of Gynaecology, the First Affiliated Hospital, Zhejiang Univerisity School of Medicine, Hangzhou, 310009, China., Bao H; Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310053, Zhejiang, China.; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China., Shu Y; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China., Ji X; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China., Fan X; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China., Pan Y; Department of Obstetrics and Gynaecology, the Affiliated Sir Run Run Shaw Hospital, Zhejiang Univerisity School of Medicine, Hangzhou, 310016, China., Tang C; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China., Wu X; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China. xiwu@zju.edu.cn.; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310015, China. xiwu@zju.edu.cn., Ruan H; Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310053, Zhejiang, China. rhf@zcmu.edu.cn.; Department of Pharmacology, Zhejiang Univerisity School of Medicine, Hangzhou, 310058, China. rhf@zcmu.edu.cn.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Jul 15; Vol. 81 (1), pp. 303. Date of Electronic Publication: 2024 Jul 15.