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Akademický článek

Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections

Autor: Jones TM, Johnson SW, DiMondi VP, Wilson DT

Publikováno v: Infection and Drug Resistance, Vol 2016, Iss Issue 1, Pp 119-128 (2016)

Travis M Jones,1,2 Steven W Johnson,1,3 V Paul DiMondi,1,4 Dustin T Wilson,1,2 1Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, 2Department of Pharmacy, Duke University Hospital, Durham, 3De

Externí odkaz: https://doaj.org/article/255027a23c4149e5905a7f61d8213de8

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Akademický článek

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Anti-MRSA quinolones for acute bacterial skin and skin structure infection: a systematic review and meta-analysis of randomized controlled trials

Autor: Chih-Cheng Lai, Chien-Ming Chao, Wei-Ting Lin, Teng-Song Weng, Yu-Hung Chen

Publikováno v: Expert Review of Anti-infective Therapy. 20:733-739

Objects This study compared the clinical efficacy and safety of anti-methicillin-resistant Staphylococcus aureus (MRSA) quinolones for treating acute bacterial skin and skin structure infections (ABSSSIs). Methods PubMed, Embase, and the Cochrane Cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a7e47ec966932af76efff077d31e04
https://doi.org/10.1080/14787210.2022.2004119

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Akademický článek

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Summary of Pharmacokinetics and Tissue Distribution of a Broad-Spectrum Fluoroquinolone, JNJ-Q2

Autor: M. Medlock, Gail McIntyre, J. Almenoff, Paul S. Covington, P. Watanalumlerd, L. Turner, M. Gotfried, J. M. Davenport

Publikováno v: Clinical Pharmacology in Drug Development. 1:121-130

This article summarizes key pharmacokinetic properties of JNJ-Q2, a broad-spectrum fluoroquinolone, being developed for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Two randomized placebo-controlled s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a71060553e049ff0255788ee3b0b4a
https://doi.org/10.1177/2160763x12454714

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Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2

Autor: Rob Towart, G McIntyre, Hua Rong Lu, Michael K. Pugsley, G Eichenbaum, JM Davenport, Jutta Rohrbacher, U Shukla, David J. Gallacher, V Hillsamer

Publikováno v: British Journal of Pharmacology. 166:1694-1707

BACKGROUND AND PURPOSE JNJ-Q2, a novel broad-spectrum fluoroquinolone with anti-methicillin-resistant Staphylococcus aureus activity, was evaluated in a comprehensive set of non-clinical and clinical cardiovascular safety studies. The effect of JNJ-Q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a77b35e94561eb88b03b747dd06a9c0
https://doi.org/10.1111/j.1476-5381.2012.01874.x

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Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary pathogens isolated from patients with community-acquired bacterial pneumonia

Autor: Douglas J. Biedenbach, Gail McIntyre, David J. Farrell, Lisa C. Liverman, Robert K. Flamm, Ronald N. Jones

Publikováno v: International Journal of Antimicrobial Agents. 39:321-325

JNJ-Q2 is a broad-spectrum fluoroquinolone with bactericidal activity against Gram-positive and Gram-negative pathogens and is currently in clinical development for the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d853da49beb1a5b2d7b80fb053ed14
https://doi.org/10.1016/j.ijantimicag.2011.11.016

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Surveillance of JNJ-Q2 activity tested against Staphylococcus aureus and beta-hemolytic streptococci as a component of the 2010 sentry antimicrobial surveillance program

Autor: Douglas J. Biedenbach, Ronald N. Jones, Lisa C. Liverman, Robert K. Flamm, David J. Farrell

Publikováno v: Diagnostic Microbiology and Infectious Disease. 71:415-420

JNJ-Q2 is a novel broad-spectrum bactericidal fluorinated 4-quinolone with potent activity against Gram-positive and -negative pathogens with a balanced potency against both DNA gyrase and topoisomerase IV targets. JNJ-Q2 is in clinical development f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9071bc4bc4a1c83e1d6eed00602d509
https://doi.org/10.1016/j.diagmicrobio.2011.08.011

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Randomized, Double-Blind, Phase II, Multicenter Study Evaluating the Safety/Tolerability and Efficacy of JNJ-Q2, a Novel Fluoroquinolone, Compared with Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infection

Autor: Gail McIntyre, June Almenoff, William O'Riordan, Paul S. Covington, Lisa C. Liverman, David Andrae, J. Michael Davenport

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:5790-5797

JNJ-Q2 is a fluoroquinolone with broad coverage including methicillin-resistant Staphylococcus aureus (MRSA). A double-blind, multicenter, phase II noninferiority study treated 161 patients for 7 to 14 days, testing the efficacy of JNJ-Q2 (250 mg, tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96490094f7f426c19ffc37163b3d05c
https://doi.org/10.1128/aac.05044-11

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A Phase 2 study of the novel fluoroquinolone JNJ-Q2 in community-acquired bacterial pneumonia

Autor: Martin E. Stryjewski, June Almenoff, David Andrae, Gail McIntyre, Paul S. Covington, Lisa Turner, J. Michael Davenport

Publikováno v: Journal of Antimicrobial Chemotherapy

Sir, JNJ-Q2 is a fifth-generation fluoroquinolone with in vitro coverage of community-acquired bacterial pneumonia (CABP) pathogens, atypical respiratory pathogens, multidrug-resistant Streptococcus pneumoniae and methicillin-resistant Staphylococcus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d6e7a254742564c22522d99126d19
http://europepmc.org/articles/PMC3797640

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