Merocyanine 540-sensitized photoinactivation of enveloped viruses in blood products: site and mechanism of phototoxicity

Autor: JM O'Brien, DK Gaffney, TP Wang, F Sieber

Publikováno v: Blood. 80:277-285

The amphipathic dye, merocyanine 540 (MC540), which preferentially photosensitizes enveloped viruses and virus-infected cells, is currently being evaluated in preclinical models as a blood sterilizing agent. In this communication, we report on an ini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c72531c577e0b5e550b04f7d1b53c581
https://doi.org/10.1182/blood.v80.1.277.bloodjournal801277

Efficacy of outpatient induction with low dose intravaginal p;rostaglandin E2: A randomized, double-blind, placebo-controlled trial

Autor: JM O'Brien, B Mercer, N Cleary, BM Sibai

Publikováno v: American Journal of Obstetrics and Gynecology. 172:424

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3be2b963e1b999a803ee20b38fd32b0
https://doi.org/10.1016/0002-9378(95)91293-2

Prescription rebate guarantees: employer insights.

Autor: Henderson R, Patterson J, O'Brien JM; National Pharmaceutical Council, 717 Pennsylvania Ave NW, Ste 800, Washington, DC 20006. Email: john.obrien@npcnow.org.

Publikováno v: The American journal of managed care [Am J Manag Care] 2024 Nov; Vol. 30 (11), pp. 574-580.

Preprocedural cardiac computed tomography versus transesophageal echocardiography for planning left atrial appendage occlusion procedures.

Autor: Soh BWT; Department of Cardiology, University Hospital Limerick, Limerick, Ireland. bsoh@tcd.ie., Gracias CS; Department of Cardiology, University Hospital Limerick, Limerick, Ireland., Sim WH; Department of Radiology, University Hospital Limerick, Limerick, Ireland., Killip M; Department of Cardiology, University Hospital Limerick, Limerick, Ireland., Waters M; Department of Cardiology, University Hospital Limerick, Limerick, Ireland., Millar KP; Department of Cardiology, University Hospital Limerick, Limerick, Ireland., O'Brien JM; Department of Radiology, University Hospital Limerick, Limerick, Ireland., Kiernan TJ; Department of Cardiology, University Hospital Limerick, Limerick, Ireland.; School of Medicine, University of Limerick, Limerick, Ireland., Arnous S; Department of Cardiology, University Hospital Limerick, Limerick, Ireland.

Publikováno v: Journal of cardiovascular imaging [J Cardiovasc Imaging] 2024 Sep 04; Vol. 32 (1), pp. 27. Date of Electronic Publication: 2024 Sep 04.

3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.

Autor: Trang KB; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pahl MC; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pippin JA; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Su C; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Littleton SH; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sharma P; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kulkarni NN; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ghanem LR; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, PA, USA., Terry NA; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, PA, USA., O'Brien JM; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA.; Penn Medicine Center for Ophthalmic Genetics in Complex Disease., Wagley Y; Department of Orthopedic Surgery University of Michigan Medical School Ann Arbor, MI, USA., Hankenson KD; Department of Orthopedic Surgery University of Michigan Medical School Ann Arbor, MI, USA., Jermusyk A; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Hoskins JW; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Amundadottir LT; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Xu M; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Brown KM; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Anderson SA; Department of Child and Adolescent Psychiatry, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yang W; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Titchenell PM; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Seale P; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cook L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.; Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Levings MK; Department of Surgery, University of British Columbia, Vancouver, BC, Canada.; BC Children's Hospital Research Institute, Vancouver, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Zemel BS; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chesi A; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wells AD; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 13. Date of Electronic Publication: 2024 Aug 13.