CTC-177, a novel drug-Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections.

Autor: Lovey A; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Lee A; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Yu A; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Krel M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Wang M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Paderu P; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA., Brady T; Departments of Medicinal Chemistry and Protein Chemistry, Cidara Therapeutics, Inc., San Diego, CA 92121, USA., Hough G; Departments of Medicinal Chemistry and Protein Chemistry, Cidara Therapeutics, Inc., San Diego, CA 92121, USA., Zhao Q; Departments of Medicinal Chemistry and Protein Chemistry, Cidara Therapeutics, Inc., San Diego, CA 92121, USA., Balkovec JM; Departments of Medicinal Chemistry and Protein Chemistry, Cidara Therapeutics, Inc., San Diego, CA 92121, USA., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.; Hackensack Meridian School of Medicine, Hackensack Meridian Health, Nutley, NJ 07110, USA.; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA., Zhao Y; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.; Hackensack Meridian School of Medicine, Hackensack Meridian Health, Nutley, NJ 07110, USA.

Publikováno v: JAC-antimicrobial resistance [JAC Antimicrob Resist] 2024 Jul 26; Vol. 6 (4), pp. dlae100. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor.

Autor: Apgar JM; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: james_apgar@merck.com., Wilkening RR; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Parker DL Jr; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Meng D; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Wildonger KJ; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Sperbeck D; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Greenlee ML; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Balkovec JM; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Flattery AM; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Abruzzo GK; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Galgoci AM; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Giacobbe RA; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Gill CJ; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Hsu MJ; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Liberator P; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Misura AS; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Motyl M; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Nielsen Kahn J; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Powles M; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Racine F; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Dragovic J; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Fan W; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Kirwan R; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Lee S; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Liu H; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Mamai A; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Nelson K; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA., Peel M; Scynexis Inc., 1 Evertrust Plaza, Jersey City, NJ 07302, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jan 15; Vol. 32, pp. 127661. Date of Electronic Publication: 2020 Nov 04.

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).

Autor: Yu Y; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address: yang_yu@merck.com., Wu Z; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Shi ZC; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., He S; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Lai Z; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Cernak TA; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Vachal P; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Liu M; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Liu J; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Hong Q; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Jian T; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Guiadeen D; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Krikorian A; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Sperbeck DM; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Verras A; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Sonatore LM; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Murphy BA; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Wiltsie J; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Chung CC; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Gorski JN; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Liu J; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Xiao J; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Wolff M; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Tong SX; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Madeira M; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Karanam BV; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Shen DM; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Balkovec JM; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., De Vita RJ; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Pinto S; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States., Nargund RP; Discovery and Preclinical Sciences, Merck & Co. Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Jun 01; Vol. 29 (11), pp. 1380-1385. Date of Electronic Publication: 2019 Mar 27.

Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro .

Autor: Jones CN; BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Ellett F; BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Robertson AL; Boston Children's Hospital, Harvard Medical School, Boston, MA, United States., Forrest KM; Cidara Therapeutics, San Diego, CA, United States., Judice K; Cidara Therapeutics, San Diego, CA, United States., Balkovec JM; Cidara Therapeutics, San Diego, CA, United States., Springer M; Cidara Therapeutics, San Diego, CA, United States., Markmann JF; BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Division of Transplantation, Massachusetts General Hospital, Boston, MA, United States., Vyas JM; Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Warren HS; Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Irimia D; BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Apr 09; Vol. 10, pp. 644. Date of Electronic Publication: 2019 Apr 09 (Print Publication: 2019).

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin.

Autor: Apgar JM; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: james_apgar@merck.com., Wilkening RR; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Greenlee ML; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Balkovec JM; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Flattery AM; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Abruzzo GK; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Galgoci AM; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Giacobbe RA; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Gill CJ; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Hsu MJ; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Liberator P; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Misura AS; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Motyl M; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Nielsen Kahn J; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Powles M; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Racine F; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Dragovic J; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Habulihaz B; Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Fan W; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Kirwan R; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Lee S; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Liu H; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Mamai A; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Nelson K; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA., Peel M; Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Dec 15; Vol. 25 (24), pp. 5813-8. Date of Electronic Publication: 2015 Oct 09.