Genome organization: connecting the developmental origins of disease and genetic variation

Autor: Elsie C. Jacobson, JK Perry, Mark H. Vickers, Justin M. O'Sullivan

Publikováno v: Journal of Developmental Origins of Health and Disease. 9:260-265

An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual’s susceptibility to these environmental challenges. These gene by environment interactions are import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ae5c9c4adc1dea10e64ab0bd67ce76
https://doi.org/10.1017/s2040174417000678

Artemin is oncogenic for human mammary carcinoma cells

Autor: Peter E. Lobie, Dong-Xu Liu, JK Perry, Vijay Pandey, Zhengsheng Wu, Jian Kang, Tao Zhu, Pengxu Qian, B Mei, Graeme C. Fielder

Publikováno v: Oncogene. 28:2034-2045

We report that artemin, a member of the glial cell line-derived neurotrophic factor family of ligands, is oncogenic for human mammary carcinoma. Artemin is expressed in numerous human mammary carcinoma cell lines. Forced expression of artemin in mamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae33e8a51a0f2e265869248d63bdf94
https://doi.org/10.1038/onc.2009.66

Cell-surface and secreted proteinases and guanidinobenzoatase activity

Autor: G.Kenneth Scott, JK Perry

Publikováno v: Bioscience Reports. 10:469-472

Hydrolysis of p-nitrophenyl guanidinobenzoate is characteristic of a tumour cell surface proteinase. We found this activity in three transformed or tumour cell lines, but not in two normal fibroblast strains. Immunochemical inhibition of plasminogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfce1fb1ce5de4c59acc4216d2f80fdb
https://doi.org/10.1007/bf01152294

P4-01-11: Autocrine Human Growth Hormone (hGH) Reduces the Sensitivity of Breast Cancer Cells to Treatment with Tamoxifen and Fulvestrant

Autor: Nicola M. Bougen, D-X Liu, H Chen, JK Perry, Peter E. Lobie

Publikováno v: Cancer Research. 71:P4-01

Despite recent advances in breast cancer treatment regimes, intrinsic or development of resistance to conventional breast cancer therapies is still a significant clinical challenge. Expression of growth factors by tumour cells has been proposed as on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df906931acfdbd7f6fcc5603ef013c77
https://doi.org/10.1158/0008-5472.sabcs11-p4-01-11

Site-Selective Zwitterionic Poly(caprolactone-carboxybetaine)-Growth Hormone Receptor Antagonist Conjugate: Synthesis and Biological Evaluation.

Autor: Yang J; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Gelb MB; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Tamshen K; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Forsythe NL; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Ko JH; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Puente EG; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Pelegri-O'Day E; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States., Jamieson SMF; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1023, New Zealand., Perry JK; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1023, New Zealand.; Liggins Institute, University of Auckland, Auckland 1203, New Zealand., Maynard HD; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States.

Publikováno v: Biomacromolecules [Biomacromolecules] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.