Zobrazeno 1 - 10
of 286
pro vyhledávání: '"JJ Reynolds"'
Publikováno v:
Journal of Endocrinology. 178:437-447
The aims of this study were to identify the role and sites of action of serine proteinases (SPs) in bone resorption, a process which involves a cascade of events, the central step of which is the removal of bone matrix by osteoclasts (OCs). This reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d10c6d8898524d7aab5f188d1d517
https://doi.org/10.1677/joe.0.1780437
https://doi.org/10.1677/joe.0.1780437
Publikováno v:
Journal of Anatomy. 191:39-48
Connective tissues synthesise and secrete a family of matrix metalloproteinases (MMPs) which are capable of degrading most components of the extracellular matrix. Animal studies suggest that the MMPs play a role in bone turnover. Using specific polyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0da8bcf6f6098587603d13e877b531
https://doi.org/10.1046/j.1469-7580.1997.19110039.x
https://doi.org/10.1046/j.1469-7580.1997.19110039.x
Publikováno v:
Bone. 17:255-260
Bone resorption is a complex multistep process that involves removal of both the organic and mineral constituents of bone matrix by proteolytic enzymes synthesized by osteoblasts and osteoclasts. To further understand the role of matrix metalloprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d5224f49e70fc1d75717a9a4bb25f8
https://doi.org/10.1016/8756-3282(95)00219-4
https://doi.org/10.1016/8756-3282(95)00219-4
Autor:
Sheila J. Jones, Alan Boyde, David J. Buttle, Peter Hill, Murary C. Meikle, Mitsuo Murata, JJ Reynolds
Publikováno v:
Journal of Cellular Biochemistry. 56:118-130
Inactivators of cysteine proteinases (CPs) were tested as inhibitors of bone resorption in vitro and in vivo. The following four CP inactivators were tested: Ep475, a compound with low membrane permeability which inhibits cathepsins B, L, S, H, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03297937e7524742ec277ceef7d81551
https://doi.org/10.1002/jcb.240560116
https://doi.org/10.1002/jcb.240560116
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1177:71-74
Recombinant human TIMP-1 and TIMP-2 (tissue inhibitors of metalloproteinases) inhibited bone resorption induced by either parathyroid hormone or 1,25-dihydroxyvitamin D 3 in cultured neonatal mouse calvariae. The inhibition was reversible, dose-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5308dd9e3d4649d7a78940070f6a511e
https://doi.org/10.1016/0167-4889(93)90159-m
https://doi.org/10.1016/0167-4889(93)90159-m
Autor:
Jeremy J. W. Breckon, JJ Reynolds, Luke W. M. Kon, Rosalind M. Hembry, Gillian Murphy, Stelios Papaioannou, Anthony Tumber, M. C. Meikle
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(11)
Sex steroids are important regulators of bone cell function and osteoblast-derived matrix metalloproteinases (MMPs) are key mediators of bone resorption during the initial stage of osteoid removal prior to osteoclast attachment. To investigate the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62008584061383c3046c98dfbbcfa030
https://pubmed.ncbi.nlm.nih.gov/10571688
https://pubmed.ncbi.nlm.nih.gov/10571688
Publikováno v:
Bone. 19(1)
Studies in some animal species have demonstrated the production of metalloproteinases by bone cells, suggesting that they may play a role in bone modeling and remodeling. The aim of the present study was to investigate the expression of collagenase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc67c35e6fadeb34e2c0b44382c6a5e
https://pubmed.ncbi.nlm.nih.gov/8830985
https://pubmed.ncbi.nlm.nih.gov/8830985
Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation
Autor:
JJ Reynolds
Publikováno v:
Oral diseases. 2(1)
BACKGROUND: Members of the family of matrix metalloproteinases (MMPs; also called collagenases or matrixins) are key enzymes in matrix degradation. They function at neutral pH and can digest synergistically all the matrix macromolecules. Biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab075bef2156dc2749f39462e9ce2cb4
https://pubmed.ncbi.nlm.nih.gov/8957940
https://pubmed.ncbi.nlm.nih.gov/8957940
Publikováno v:
Bone. 15:449-449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6c98c7b4039e2ba71def6b8adcf5fa
https://doi.org/10.1016/8756-3282(94)90824-9
https://doi.org/10.1016/8756-3282(94)90824-9
Publikováno v:
Bone. 15:458-458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf821fd2dffcb27d9fc6b7aef77699e
https://doi.org/10.1016/8756-3282(94)90861-3
https://doi.org/10.1016/8756-3282(94)90861-3