Zobrazeno 1 - 10
of 33
pro vyhledávání: '"JJ Patten"'
Autor:
Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh
Publikováno v:
Nature Cancer. 2:1071-1085
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which a
Autor:
Alex M. Jaeger, David Canner, Mary Clare Beytagh, JJ Patten, William M. Rideout, Haley Hauck, Isidro Cortes-Ciriano, Santiago Naranjo, Abbey Jin, Zackery A. Ely, Tyler Jacks, Nathan J. Sacks, Roderick T. Bronson, Peter M. K. Westcott, Francesc Muyas, Arjun Bhutkar, Olivia Smith, Daniel Zhang, Amanda M. Cruz
DNA mismatch repair deficiency (MMRd) is associated with high tumor mutational burden (TMB), increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therapy1. Nevertheless, about half of MMRd tumors do not res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f615eadc4d03bce6cde32dfce858f582
https://doi.org/10.21203/rs.3.rs-879464/v1
https://doi.org/10.21203/rs.3.rs-879464/v1
Autor:
Alex M. Jaeger, Zackery A. Ely, Peter M. K. Westcott, Amanda M. Cruz, David Canner, Francesc Muyas, Mary Clare Beytagh, JJ Patten, Isidro Cortes-Ciriano, Haley Hauck, Abbey Jin, Roderick T. Bronson, Santiago Naranjo, Daniel Zhang, William M. Rideout, Tyler Jacks, Arjun Bhutkar, Nathan J. Sacks, Olivia Smith
DNA mismatch repair deficiency (MMRd) in human cancer is associated with high tumor mutational burden (TMB), frameshift mutation-derived neoantigens, increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7b8c8cec8f49449a9abd0ac0e96334
https://doi.org/10.1101/2021.08.24.457572
https://doi.org/10.1101/2021.08.24.457572
Autor:
Keiser PT; Department of Virology, Immunology, and Microbiology, Boston University Medical School, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA., Zhang W; Boston University Center for Molecular Discovery (BU-CMD), Department of Chemistry, Boston University, Boston, MA, 02215, USA., Ricca M; Boston University Center for Molecular Discovery (BU-CMD), Department of Chemistry, Boston University, Boston, MA, 02215, USA., Wacquiez A; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA; Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA., Grimins A; Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA., Cencic R; Department of Biochemistry, Department of Oncology and Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada, H3G 1Y6., Patten JJ; Department of Virology, Immunology, and Microbiology, Boston University Medical School, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA., Shah P; National Institutes of Health, National Center for Advancing Translational Sciences, Bethesda, MD, 20892, USA., Padilha E; National Institutes of Health, National Center for Advancing Translational Sciences, Bethesda, MD, 20892, USA., Connor JH; Department of Virology, Immunology, and Microbiology, Boston University Medical School, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA., Pelletier J; Department of Biochemistry, Department of Oncology and Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada, H3G 1Y6., Lyons SM; Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA., Saeed M; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA; Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, 02118, USA., Brown LE; Boston University Center for Molecular Discovery (BU-CMD), Department of Chemistry, Boston University, Boston, MA, 02215, USA., Porco JA Jr; Boston University Center for Molecular Discovery (BU-CMD), Department of Chemistry, Boston University, Boston, MA, 02215, USA., Davey RA; Department of Virology, Immunology, and Microbiology, Boston University Medical School, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, MA, 02118, USA. Electronic address: radavey@bu.edu.
Publikováno v:
Antiviral research [Antiviral Res] 2024 Oct; Vol. 230, pp. 105976. Date of Electronic Publication: 2024 Aug 06.
Autor:
Durante D; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States., Bott R; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States., Cooper L; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States., Owen C; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States., Morsheimer KM; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States., Patten JJ; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States., Zielinski C; UICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States., Peet NP; Chicago BioSolutions Inc., Chicago, Illinois 60612, United States., Davey RA; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts 02118, United States., Gaisina IN; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.; Chicago BioSolutions Inc., Chicago, Illinois 60612, United States.; UICentre: Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States., Rong L; Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.; Chicago BioSolutions Inc., Chicago, Illinois 60612, United States., Moore TW; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.; University of Illinois Cancer Center, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 13737-13764. Date of Electronic Publication: 2024 Aug 06.
Autor:
Carlson RJ; Massachusetts Institute of Technology, Department of Health Sciences and Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Patten JJ; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Stefanakis G; Laboratory for Information & Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA., Soong BY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Radhakrishnan A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard School of Engineering and Applied Sciences, Cambridge, MA, USA., Singh A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Thakur N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Amarasinghe GK; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Cancer Center, Boston, MA, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leung D; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Uhler C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Information & Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA., Davey RA; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Blainey PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 07. Date of Electronic Publication: 2024 Apr 07.
Autor:
Xu D; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305., Powell AE; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305., Utz A; Sarafan ChEM-H, Stanford University, Stanford, CA 94305.; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA 94305.; Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA 94305., Sanyal M; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305., Do J; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305., Patten JJ; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118., Moliva JI; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118., Sullivan NJ; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118.; Department of Biology, Boston University, Boston, MA 02118., Davey RA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118., Kim PS; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305.; Chan Zuckerberg Biohub, San Francisco, CA 94158.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 13; Vol. 121 (7), pp. e2316960121. Date of Electronic Publication: 2024 Feb 06.
Autor:
Bird GH; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Patten JJ; Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA., Zavadoski W; ATP R&D Labs, Branford, CT, 06405, USA., Barucci N; ATP R&D Labs, Branford, CT, 06405, USA., Godes M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Moyer BM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Owen CD; Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA., DaSilva-Jardine P; Red Queen Therapeutics, Inc., Cambridge, MA, 02142, USA., Neuberg DS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Bowen RA; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Davey RA; Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA., Walensky LD; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. Loren_Walensky@dfci.harvard.edu.; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. Loren_Walensky@dfci.harvard.edu.
Publikováno v:
Nature communications [Nat Commun] 2024 Jan 04; Vol. 15 (1), pp. 274. Date of Electronic Publication: 2024 Jan 04.
Autor:
Xu D; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA., Powell AE; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA., Utz A; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA.; Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA 94305, USA., Sanyal M; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA., Do J; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA., Patten JJ; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA., Moliva JI; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA., Sullivan NJ; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.; Department of Biology, Boston University, Boston, MA 02118, USA., Davey RA; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.; Department of Virology, Immunology, and Microbiology, Boston University School of Medicine, Boston, MA 02118, USA., Kim PS; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 17. Date of Electronic Publication: 2023 Oct 17.
Autor:
Aguilar-Briseño JA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA., Elliff JM; Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA., Patten JJ; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA., Wilson LR; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA., Davey RA; Department of Virology, Immunology, and Microbiology, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA., Bailey AL; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA., Maury WJ; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.; Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
Publikováno v:
Viruses [Viruses] 2023 Oct 11; Vol. 15 (10). Date of Electronic Publication: 2023 Oct 11.