Zobrazeno 1 - 10
of 50
pro vyhledávání: '"JIAN-MING LÜ"'
Autor:
Christian Marin-Muller, Dali Li, Jian-Ming Lü, Zhengdong Liang, Osvaldo Vega-Martínez, Sue E. Crawford, Mary K. Estes, William E. Fisher, Changyi Chen, Qizhi Yao
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2038 (2023)
Pancreatic ductal adenocarcinoma (PDAC) remains an extremely aggressive disease characterized by rapidly acquired multi-drug resistance, including to first-line chemotherapeutic agent gemcitabine. Autophagy is a process that is often exploited by can
Externí odkaz:
https://doaj.org/article/f116cb6dc4b44b109840462a44d78046
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 841 (2021)
We previously reported a new polymer, lactic-co-glycolic acid-polyethylenimine (LGA-PEI), as an improved nanoparticle (NP) delivery for therapeutic nucleic acids (TNAs). Here, we further developed two antibody (Ab)-conjugated LGA-PEI NP technologies
Externí odkaz:
https://doaj.org/article/e7bda0ed1c2e40608badf0d11d3ec002
Autor:
VASILE DINOIU, JIAN-MING LÜ
Publikováno v:
Journal of the Serbian Chemical Society, Vol 71, Iss 4, Pp 323-330 (2006)
3,5-Dialkyl-4-hydroxybenzylhydrazine 1 reacted with hexafluoroacetylacetone, and trifluoroacetylacetone yielding the pyrazoles 2 bearing trifluoromethyl and/or methyl substituents in positions 3 and 5. The same hydrazine derivatives 1 afforded the py
Externí odkaz:
https://doaj.org/article/813901c6527d44e8b41ed533ae121df8
Publikováno v:
Clinical Practice Review and Meta-Analysis. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b9a4e38dc5f533770a6cc7c9a1870a
https://doi.org/10.12659/cprm.924530
https://doi.org/10.12659/cprm.924530
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 2
International Journal of Molecular Sciences, Vol 20, Iss 2, p 294 (2019)
Volume 20
Issue 2
International Journal of Molecular Sciences, Vol 20, Iss 2, p 294 (2019)
We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy (HAART) drug, can cause endothelial dysfunction through oxidative stress. Several antioxidants including ginsenoside Rb1, a compound with antioxidant effect, can e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78f1b2ce400a3c09fa4ff8de4ced039
Publikováno v:
Nanomedicine. 11:1971-1991
Aim: To develop an improved delivery system for nucleic acids. Materials & methods: We designed, synthesized and characterized a new polymer of lactic-co-glycolic acid-modified polyethylenimine (LGA-PEI). Functions of LGA-PEI polymer were determined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fbbbde15c08d1111d094849bc26709
https://doi.org/10.2217/nnm-2016-0128
https://doi.org/10.2217/nnm-2016-0128
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS). Uric acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6f3e39dca29f29a896390ebf696cda
https://doi.org/10.12659/msm.899852
https://doi.org/10.12659/msm.899852
Publikováno v:
Current Pharmaceutical Design. 20:3563-3578
Cardiovascular disease remains the number one killer in the United States and many other countries. Each year, there are enormous research efforts on its pathogenesis, prevention and treatment led by scientists worldwide. One of the most significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ca7d6790688a93c8932984a28f5d8c
https://doi.org/10.2174/13816128113196660744
https://doi.org/10.2174/13816128113196660744
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Entacapone (ENT), a clinical drug for the treatment of Parkinson's disease, has been shown to have antioxidant effects, but little is known about its antioxidant mechanisms. The objective of the current study was to determine the antioxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5a129ca705a665b39c93589a5d2b3e
https://pubmed.ncbi.nlm.nih.gov/26927838
https://pubmed.ncbi.nlm.nih.gov/26927838
Autor:
Zhengdong Liang, Edward B. Siwak, Shaoyu Yan, Sarah M. Weakley, Saha Jamaluddin, Changyi Chen, Qizhi Yao, Jian-Ming Lü
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Summary Background Several HIV protease mutations, which are resistant to clinical HIV protease inhibitors (PIs), have been identified. There is a great need for second-generation PIs with different chemical structures and/or with an alternative mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7e47099ea941246fb87065963490c4
http://europepmc.org/articles/PMC3560711
http://europepmc.org/articles/PMC3560711