Zobrazeno 1 - 10
of 85
pro vyhledávání: '"JI MacRae"'
Autor:
CT Stankey, C Bourges, T Turner-Stokes, AP Piedade, C Palmer-Jones, I Papa, M Dos Silva dos Santos, LO Randzavola, L Speidel, EC Parkes, W Edwards, AP Rochford, CD Murray, JI MacRae, P Skoglund, C Wallace, MZ Cader, DC Thomas, JC Lee
Increasing global rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1and high failure rates during drug development2– underscoring an urgent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b6133f81a729bebf8e7c96d026e458
https://doi.org/10.1101/2023.05.05.539522
https://doi.org/10.1101/2023.05.05.539522
Autor:
Dj, Creek, Hh, Chua, Sa, Cobbold, Brunda Nijagal, Ji, Macrae, Bk, Dickerman, Pr, Gilson, Sa, Ralph, Mj, Mcconville
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b05f96576a0bf03aaf1614db1ae91690
http://europepmc.org/abstract/med/27572396
http://europepmc.org/abstract/med/27572396
Autor:
Yazicioglu YF; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Marin E; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Andrew HF; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Bentkowska K; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Johnstone JC; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Mitchell R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Wong ZY; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Zec K; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Fergusson J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Borsa M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Raza IGA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Ali M; Nuffield Department of Medicine Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Kronsteiner B; Nuffield Department of Medicine Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Furlani IL; Metabolomics STP, Francis Crick Institute, London NW1 1AT, UK., MacRae JI; Metabolomics STP, Francis Crick Institute, London NW1 1AT, UK., Devine MJ; Mitochondrial Neurobiology Laboratory, Francis Crick Institute, London NW1 1AT, UK; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Coles M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Dunachie SJ; Nuffield Department of Medicine Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; National Institute for Health and Care Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Clarke AJ; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Publikováno v:
Science immunology [Sci Immunol] 2024 Dec 13; Vol. 9 (102), pp. eadl4613. Date of Electronic Publication: 2024 Dec 13.
Autor:
Ocasio CA; The Francis Crick Institute, London, UK., Baggelaar MP; The Francis Crick Institute, London, UK.; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK.; Utrecht University, Biomolecular Mass Spectrometry & Proteomics Group, Utrecht, The Netherlands., Sipthorp J; The Francis Crick Institute, London, UK.; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK., Losada de la Lastra A; The Francis Crick Institute, London, UK.; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK., Tavares M; The Francis Crick Institute, London, UK.; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK., Volarić J; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK., Soudy C; The Francis Crick Institute, London, UK., Storck EM; King's College London, Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and Department of Chemistry, London, UK., Houghton JW; The Francis Crick Institute, London, UK., Palma-Duran SA; The Francis Crick Institute, London, UK.; Department of Food Science, Research Center in Food and Development A.C., Hermosillo, Mexico., MacRae JI; The Francis Crick Institute, London, UK., Tomić G; The Francis Crick Institute, London, UK., Carr L; The Francis Crick Institute, London, UK., Downward J; The Francis Crick Institute, London, UK., Eggert US; King's College London, Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and Department of Chemistry, London, UK., Tate EW; The Francis Crick Institute, London, UK. e.tate@imperial.ac.uk.; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, London, UK. e.tate@imperial.ac.uk.
Publikováno v:
Nature biotechnology [Nat Biotechnol] 2024 Oct; Vol. 42 (10), pp. 1548-1558. Date of Electronic Publication: 2024 Jan 08.
Autor:
Stankey CT; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.; Washington University School of Medicine, St Louis, MO, USA., Bourges C; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Haag LM; Division of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Turner-Stokes T; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Piedade AP; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Palmer-Jones C; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Papa I; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Silva Dos Santos M; Metabolomics STP, The Francis Crick Institute, London, UK., Zhang Q; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK., Cameron AJ; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Legrini A; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Zhang T; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Wood CS; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., New FN; NanoString Technologies, Seattle, WA, USA., Randzavola LO; Department of Immunology and Inflammation, Imperial College London, London, UK., Speidel L; Ancient Genomics Laboratory, The Francis Crick Institute, London, UK.; Genetics Institute, University College London, London, UK., Brown AC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hall A; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK.; Department of Cellular Pathology, Royal Free Hospital, London, UK., Saffioti F; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK.; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK., Parkes EC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Edwards W; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK., Direskeneli H; Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey., Grayson PC; Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, USA., Jiang L; Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China., Merkel PA; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Saruhan-Direskeneli G; Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Sawalha AH; Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Lupus Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Tombetti E; Department of Biomedical and Clinical Sciences, Milan University, Milan, Italy.; Internal Medicine and Rheumatology, ASST FBF-Sacco, Milan, Italy., Quaglia A; Department of Cellular Pathology, Royal Free Hospital, London, UK.; UCL Cancer Institute, London, UK., Thorburn D; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK.; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK., Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Chinese Academy of Medical Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Comprehensive Biomedical Research Centre, Oxford, UK., Rochford AP; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Murray CD; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Divakar P; NanoString Technologies, Seattle, WA, USA., Green M; Experimental Histopathology STP, The Francis Crick Institute, London, UK., Nye E; Experimental Histopathology STP, The Francis Crick Institute, London, UK., MacRae JI; Metabolomics STP, The Francis Crick Institute, London, UK., Jamieson NB; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Skoglund P; Ancient Genomics Laboratory, The Francis Crick Institute, London, UK., Cader MZ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Wallace C; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK., Thomas DC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Lee JC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK. james.lee@crick.ac.uk.; Department of Gastroenterology, Royal Free Hospital, London, UK. james.lee@crick.ac.uk.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK. james.lee@crick.ac.uk.
Publikováno v:
Nature [Nature] 2024 Jun; Vol. 630 (8016), pp. 447-456. Date of Electronic Publication: 2024 Jun 05.
Autor:
Giampazolias E; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Pereira da Costa M; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Lam KC; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA., Lim KHJ; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.; Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK., Cardoso A; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Piot C; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Chakravarty P; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK., Blasche S; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK., Patel S; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Biram A; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Castro-Dopico T; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Buck MD; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Rodrigues RR; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.; Microbiome and Genetics Core, LICI, CCR, NCI, Bethesda, MD 20892, USA., Poulsen GJ; National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark., Palma-Duran SA; Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK., Rogers NC; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Koufaki MA; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Minutti CM; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Wang P; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Vdovin A; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Frederico B; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Childs E; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Lee S; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Simpson B; Tumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK., Iseppon A; AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Omenetti S; AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Kelly G; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK., Goldstone R; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK., Nye E; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK., Suárez-Bonnet A; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.; Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK., Priestnall SL; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.; Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK., MacRae JI; Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK., Zelenay S; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK., Patil KR; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK., Litchfield K; Tumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK., Lee JC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London NW1 1AT, UK.; Institute of Liver and Digestive Health, Division of Medicine, Royal Free Hospital, University College London, London NW3 2QG, UK., Jess T; National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark., Goldszmid RS; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA., Reis E Sousa C; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Publikováno v:
Science (New York, N.Y.) [Science] 2024 Apr 26; Vol. 384 (6694), pp. 428-437. Date of Electronic Publication: 2024 Apr 25.
Autor:
Grimm F; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Asuaje A; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Jain A; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Silva Dos Santos M; Metabolomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Kleinjung J; Computational Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Nunes PM; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Gehrig S; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Fets L; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Darici S; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., MacRae JI; Metabolomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Anastasiou D; Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK. dimitrios.anastasiou@crick.ac.uk.
Publikováno v:
The EMBO journal [EMBO J] 2024 Apr; Vol. 43 (8), pp. 1545-1569. Date of Electronic Publication: 2024 Mar 14.
Autor:
D'Avola A, Legrave N, Tajan M, Chakravarty P, Shearer RL, King HW, Kluckova K, Cheung EC, Clear AJ, Gunawan AS, Zhang L, James LK, MacRae JI, Gribben JG, Calado DP, Vousden KH, Riches JC
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2024 Feb 15; Vol. 134 (4). Date of Electronic Publication: 2024 Feb 15.
Autor:
de Boer LL; The Francis Crick Institute, London, NW1 1AT, UK.; Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK.; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, 171 65, Stockholm, Sweden., Vanes L; The Francis Crick Institute, London, NW1 1AT, UK., Melgrati S; The Francis Crick Institute, London, NW1 1AT, UK.; Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK.; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland., Biggs O'May J; The Francis Crick Institute, London, NW1 1AT, UK., Hayward D; The Francis Crick Institute, London, NW1 1AT, UK.; GSK, Stevenage, SG1 2NY, UK., Driscoll PC; The Francis Crick Institute, London, NW1 1AT, UK., Day J; Department of Earth Sciences, University of Cambridge, Cambridge, CB2 3EQ, UK., Griffiths A; London Metallomics Facility, Research Management & Innovation Directorate, King's College London, London, SE1 1UL, UK., Magueta R; London Metallomics Facility, Research Management & Innovation Directorate, King's College London, London, SE1 1UL, UK., Morrell A; London Metallomics Facility, Research Management & Innovation Directorate, King's College London, London, SE1 1UL, UK., MacRae JI; The Francis Crick Institute, London, NW1 1AT, UK., Köchl R; The Francis Crick Institute, London, NW1 1AT, UK.; Kings College London, London, SE1 9RT, UK., Tybulewicz VLJ; The Francis Crick Institute, London, NW1 1AT, UK. Victor.T@crick.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2023 Dec 06; Vol. 14 (1), pp. 7844. Date of Electronic Publication: 2023 Dec 06.
Autor:
Rzechorzek NJ; DNA Recombination and Repair Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Kunzelmann S; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Purkiss AG; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Silva Dos Santos M; Metabolomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., MacRae JI; Metabolomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Taylor IA; Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Fugger K; DNA Recombination and Repair Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; University College London Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK., West SC; DNA Recombination and Repair Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. stephen.west@crick.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2023 Oct 26; Vol. 14 (1), pp. 6809. Date of Electronic Publication: 2023 Oct 26.