Zobrazeno 1 - 10 of 496 pro vyhledávání: '"JH Griffin"'
1
Direct detection of activated protein C in blood from human subjects
Autor: A Gruber, JH Griffin
Publikováno v: Blood. 79:2340-2348
The antithrombotic enzyme, activated protein C (APC) was measured in blood using an enzyme capture assay (ECA). The ECA involved (1) collection of blood into anticoagulant containing a reversible inhibitor of the enzyme, (2) specific affinity capture
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80c040ae38a8bdbe377f7ed181b1af19
https://doi.org/10.1182/blood.v79.9.2340.2340
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2
Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII
Autor: Aj, Gale, Jean-Luc Pellequer, Ed, Getzoff, Jh, Griffin
Publikováno v: Europe PubMed Central
Three dimensional homology models for the C1 and C2 domains of factor VIII (FVIII) were generated. Each C domain formed a beta-sandwich, and C1 was covalently connected to C2 in a head-to-head orientation. Of the250 missense mutations that cause FVII
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0407f853d08be4f6cd3925501a0e63ac
https://pubmed.ncbi.nlm.nih.gov/10669159
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3
The carbohydrate moiety of factor V modulates inactivation by activated protein C
Autor: Ja, Fernández, Tilman Hackeng, Kojima K, Jh, Griffin
Publikováno v: Europe PubMed Central
An important risk factor for thrombosis is the polymorphism R506Q in factor V that causes resistance of factor Va to proteolytic inactivation by activated protein C (APC). To study the potential influence of the carbohydrate moieties of factor Va on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::876dd58c7f5bd373a7900921e7994f35
https://pubmed.ncbi.nlm.nih.gov/9192757
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4
Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM
Autor: Martine Aiach, JH Griffin, Brigitte Jude, Martine Alhenc-Gelas, JF Abgrall, JS Greengard, Sophie Gandrille, Irène Juhan-Vague
Publikováno v: Blood. 86(1)
Because multiple risk factors in one patient may increase the clinical expression of thrombophilia, we assessed the presence in protein C- deficient patients of the factor V Arg 506 Gln mutation responsible for activated protein C resistance. Using a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becabca70a0f1fefe828a98191bef7e4
https://pubmed.ncbi.nlm.nih.gov/7795227
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5
Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin
Autor: JH Griffin, A Gruber, JA Fernandez
Publikováno v: Blood. 79(12)
The levels of total, free, and bound protein S and C4BP were determined using enzyme-linked immunosorbent assays (ELISAs) in plasma samples (8 males and 8 females) that were individually subjected to immunoadsorption studies in which “free protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd9c4c56fe76917ae63ae1489ae8385
https://pubmed.ncbi.nlm.nih.gov/1534488
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6
In vivo and in vitro complexes of activated protein C with two inhibitors in baboons
Autor: F Espana, A Gruber, MJ Heeb, SR Hanson, LA Harker, JH Griffin
Publikováno v: Blood. 77(8)
In vivo complex formation of activated protein C with protein C inhibitor (APC-PCI) and with alpha 1-antitrypsin (APC-alpha 1AT) following infusion of 0.25 or 1.0 mg APC/kg in 1 hour into baboons was studied using immunoblotting and sandwich enzyme-l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76525b180489a446b8705d978973ca54
https://pubmed.ncbi.nlm.nih.gov/1849759
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7
Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V
Autor: CA Fulcher, JE Gardiner, JH Griffin, TS Zimmerman
Publikováno v: Blood. 63:486-489
Purified human factor VIII procoagulant protein (VIII:C) was treated with purified human activated protein C (APC) and the loss of VIII:C activity correlated with proteolysis of the VIII:C polypeptides. APC proteolyzed all VIII:C polypeptides with mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7b9cb3c3f81c8ad550f3af4ac3df219
https://doi.org/10.1182/blood.v63.2.486.486
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9
Properties of sulfatides in factor-XII-dependent contact activation
Autor: G Tans, JH Griffin
Publikováno v: Blood. 59:69-75
Incubation of normal human plasma with low amounts of sulfatides resulted in the initiation of intrinsic coagulation and the appearance of kallikrein activity. The optimal initiation of procoagulant and kallikrein amidolytic activity was dependent on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::614370f097c78a5fd6aae3efc60ed2a0
https://doi.org/10.1182/blood.v59.1.69.bloodjournal59169
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10
A comparison between activated protein C and des-1-41-light chain- activated protein C in reactions with type 1 plasminogen activator inhibitor
Autor: CL Gladson, RR Schleef, BR Binder, DJ Loskutoff, JH Griffin
Publikováno v: Blood. 74:173-181
This study investigates the role of the gamma-carboxyglutamic acid (gla) containing domain of activated protein C in interactions with both platelet-derived and purified type 1 plasminogen activator inhibitor (PAI-1). The activity of human platelet P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5a904465c53388dabbfe9795a295d2
https://doi.org/10.1182/blood.v74.1.173.bloodjournal741173
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