Výsledky vyhledávání

Genetic engineering of pigs to provide organs for xenotransplantation

Autor: David Jg White

Publikováno v: Current Opinion in Organ Transplantation. 11:160-165

Purpose of review This article reviews the recent advances in the genetic engineering of animals, specifically the pig, to provide organs to transplant into humans without provoking uncontrollable rejection. Recent findings The utility of making pigs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a9e88c264d6ae8b9eed9605981a9b5
https://doi.org/10.1097/01.mot.0000218930.42644.01

Zobrazit plný text záznamu

Platelets inhibit the induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells

Autor: S. Catovsky, V. B. Schini, William Durante, Paul M. Vanhoutte, Timothy Scott-Burden, JG White, Andrew I. Schafer, Michael H. Kroll

Publikováno v: Blood. 83:1831-1838

We have investigated the role of platelets in regulating the hemostatic and vasomotor properties of vascular smooth muscle. Experiments were performed to examine the effect of the releasate from activated platelets on the production of nitric oxide f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58c01e22137ab568680dc6d35e41f48d
https://doi.org/10.1182/blood.v83.7.1831.1831

Zobrazit plný text záznamu

Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency

Autor: Sara J. Israels, JG White, CJ Witkop, Eileen M Mcmillan, G Michaud, Abraham Shalev, WL Nichols, Sandra Singhroy, Arnold H. Greenberg, Archibald McNicol

Publikováno v: Blood. 80:1231-1237

An antigen-capture sandwich enzyme-linked immunosorbent assay (ELISA) was developed for a novel protein granulophysin, a constituent of the platelet dense granule (DG) membrane and used to characterize patients with dense granule storage pool deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f8bab3e2383c3bfe99c1b51a5dfcb9
https://doi.org/10.1182/blood.v80.5.1231.bloodjournal8051231

Zobrazit plný text záznamu

Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases

Autor: G. de Gaetano, Virgilio Evangelista, G. Rajtar, C. Cerletti, JG White

Publikováno v: Europe PubMed Central

Human polymorphonuclear leukocytes (PMN) activated by fMLP (in the presence of CaCl2, fibrinogen, and cytochalasin B) were able to induce aggregation, cytoplasmic Ca2+ increase, and thromboxane A2 production in coincubated autologousplatelets. Cell-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c379773a356297ca12ba757f6b86338
https://doi.org/10.1182/blood.v77.11.2379.bloodjournal77112379

Zobrazit plný text záznamu

Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinases: role of P-selectin-mediated cell-cell adhesion

Autor: JG White, Virgilio Evangelista, G. de Gaetano, P. Piccardoni, Chiara Cerletti

Publikováno v: Europe PubMed Central

Human PMN stimulated by fMLP are able to activate coincubated, autologous platelets. Cathepsin G, a neutral serine protease stored in the azurophilic granules of PMN, is the major platelet activator in this system. We previously proposed that shear-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b3661d9259712c13a726b667151b51
https://pubmed.ncbi.nlm.nih.gov/7684621

Zobrazit plný text záznamu

Detergent-resistant cytoskeleton of the surface-activated platelet differs from the suspension-activated platelet cytoskeleton

Autor: CM Smith, SM Burris, GH Rao, JG White

Publikováno v: Blood. 80(11)

This study contrasts the protein composition of the detergent-resistant cytoskeleton of platelets fully spread on glass with the cytoskeletal composition of resting platelets and platelets aggregated in suspension with thrombin. Complete Triton X-100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cb65f4be798c97fb39afaf637a0c57
https://pubmed.ncbi.nlm.nih.gov/1450404

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání