Zobrazeno 1 - 10
of 199
pro vyhledávání: '"JG LeHoux"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 80:99-107
In order to understand the activity specificity of the hamster cytochrome P450 17 alpha-hydroxylase/17,20-lyase (P450c17), we have studied its structure/activity using three hamster P450c17 recombinant mutants (T202N/D240N/D407H). In transiently tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01f143478836cda6593bcd8bfa38ad8
https://doi.org/10.1016/s0960-0760(01)00172-8
https://doi.org/10.1016/s0960-0760(01)00172-8
Publikováno v:
Journal of Molecular Endocrinology. 19:203-206
Complementary DNAs encoding the hamster type 2 3 beta-hydroxysteroid dehydrogenase/delta 5-->4 isomerase were isolated from liver and kidney cDNA libraries. Nine clones were isolated containing identical coding and 3' untranslated sequences. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4c3ef251b76f929b9f6259cb51a4af
https://doi.org/10.1677/jme.0.0190203
https://doi.org/10.1677/jme.0.0190203
Autor:
JG LeHoux, Cloutier M, Andrée Lefebvre, Steeve Véronneau, L. Ducharme, Courtemanche J, Hugues Bernard, JI Mason
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 57:125-139
We have isolated a hamster adrenal P 450C11 cDNA which shared 90 and 84% homology, respectively, with the nucleotide sequence and the amino acid sequence of the hamster adrenal P 450aldo. Both P 450C11 and P 450aldo cDNA coding sequences were inserte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e3601f499b051b53f28e8fb1b77b0f
https://doi.org/10.1016/0960-0760(95)00249-9
https://doi.org/10.1016/0960-0760(95)00249-9
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 55:481-487
The enzyme 3β-hydroxysteroid dehydrogenase Δ 5→4 - isomerase (3β-HSD) is essential for the production of all classes of steroid hormones. Multiple isozymes of this enzyme have been demonstrated in the kidney and liver of both the rat and the mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7abb7453a1017f82bc8d11727303faa
https://doi.org/10.1016/0960-0760(95)00197-2
https://doi.org/10.1016/0960-0760(95)00197-2
Publikováno v:
Biochimica et biophysica acta. 1619(3)
The cytochrome P450c17 isoforms from various animal species have different substrate selectivity, especially for 17,20-lyase activity. In particular, the human P450c17 selectively produces dehydroepiandrosterone with little androstenedione (AD). Hams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e73011ab22780d4729f38fb6cece5e
https://pubmed.ncbi.nlm.nih.gov/12573489
https://pubmed.ncbi.nlm.nih.gov/12573489
Publikováno v:
Journal of molecular endocrinology. 29(3)
The steroidogenic acute regulatory protein (StAR) is the major entrance for cholesterol in mitochondria under acute stimulation. Under such circumstances, dysfunctional StAR activity can ultimately lead to lipoid congenital adrenal hyperplasia (LCAH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b45035808d6b357bc7b6a9c999c1fc
https://pubmed.ncbi.nlm.nih.gov/12459035
https://pubmed.ncbi.nlm.nih.gov/12459035
Publikováno v:
Journal of molecular endocrinology. 21(2)
In this study, we report the cDNA cloning of hamster adrenal steroidogenic acute regulatory (StAR) protein and the effect of adrenocorticotrophin (ACTH) on its expression in vivo. A hamster adrenal cDNA library was screened using an 852 bp fragment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9b05b7039ad2d35fb8aa4943cf6c38
https://pubmed.ncbi.nlm.nih.gov/9801456
https://pubmed.ncbi.nlm.nih.gov/9801456
Publikováno v:
Journal of molecular endocrinology. 20(1)
Western blot analyses of various hamster tissues reveal high levels of expression of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) in adrenal and liver, and moderate levels of expression in kidney. The expression in liver is sexually dimorphic; ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740f23a25f1876c3622b325d9ef9a665
https://pubmed.ncbi.nlm.nih.gov/9513086
https://pubmed.ncbi.nlm.nih.gov/9513086
Publikováno v:
Endocrinology. 134(2)
Angiotensin-II (AII), a component of the renin-angiotensin system, is the major factor that regulates the formation of aldosterone in the adrenal cortex zona glomerulosa (ZG). The activity of this system is increased by an increase in potassium intak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b322d0344ffcc72883caecef0b91bd1
https://pubmed.ncbi.nlm.nih.gov/7507836
https://pubmed.ncbi.nlm.nih.gov/7507836
Publikováno v:
Endocrinology. 131(4)
The hamster, a rodent possessing adrenal 17 alpha-hydroxylase activity, was used to study the effect of ACTH on the regulation of cortisol formation in vivo. The characterization of the mRNA and protein of hamster adrenal steroidogenic enzymes reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc43e1751c93858290d2a8841b85251
https://pubmed.ncbi.nlm.nih.gov/1327721
https://pubmed.ncbi.nlm.nih.gov/1327721