Zobrazeno 1 - 10
of 333
pro vyhledávání: '"JG Kelton"'
Autor:
JN George, SH Woolf, GE Raskob, JS Wasser, LM Aledort, PJ Ballem, VS Blanchette, JB Bussel, DB Cines, JG Kelton, AE Lichtin, R McMillan, JA Okerbloom, DH Regan, I Warrier
Publikováno v:
Blood. 88:3-40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b681add3c55aae2529fcac0eba22728
https://doi.org/10.1182/blood.v88.1.3.3
https://doi.org/10.1182/blood.v88.1.3.3
Publikováno v:
Blood. 83:3232-3239
Heparin-induced thrombocytopenia (HIT) is an important complication of heparin therapy. Although there is general agreement that platelet activation in vitro by the HIT IgG is mediated by the platelet Fc receptor, the interaction among the antibody,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f443b27d1c2debf2d9e0ecd1108d46db
https://doi.org/10.1182/blood.v83.11.3232.bloodjournal83113232
https://doi.org/10.1182/blood.v83.11.3232.bloodjournal83113232
Autor:
C Demers, JS Ginsberg, P Brill-Edwards, A Panju, TE Warkentin, DR Anderson, C Turner, JG Kelton
Publikováno v:
Blood. 78:2194-2197
In order to determine the efficacy and safety of ancrod, a rapid acting defibrinogenating drug, for patients with heparin-induced thrombocytopenia, 11 consecutive patients who required anticoagulant therapy because of venous thromboembolism and who d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aaa5d0dbfebe3f839b4908ae5f38ea7
https://doi.org/10.1182/blood.v78.9.2194.bloodjournal7892194
https://doi.org/10.1182/blood.v78.9.2194.bloodjournal7892194
Publikováno v:
Europe PubMed Central
Heparin-induced thrombocytopenia (HIT) with thrombosis is a serious complication of heparin use. HIT sera can generate platelet-derived microparticles, which are produced in a heparin-dependent manner and are hypothesized to be important initial path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7333af22e8ff6e6d896f6a62e67a87b3
https://pubmed.ncbi.nlm.nih.gov/10891450
https://pubmed.ncbi.nlm.nih.gov/10891450
Publikováno v:
Europe PubMed Central
To determine whether factor V Leiden is associated with thrombotic events in patients with heparin-induced thrombocytopenia (HIT), we evaluated 165 patients with serologically confirmed HIT for the presence of factor V Leiden and determined the incid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::27fd775a0d26d695f141254464030960
https://pubmed.ncbi.nlm.nih.gov/9459322
https://pubmed.ncbi.nlm.nih.gov/9459322
Publikováno v:
Europe PubMed Central
Multimerin is a massive soluble, multimeric protein found in platelets and endothelial cells. Recent studies identified multimerin as a specific coagulation factor V binding protein, complexed with platelet, but not plasma, factor V. These findings l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c3ff1ffa0d17562bc55045456640d16
https://pubmed.ncbi.nlm.nih.gov/8652809
https://pubmed.ncbi.nlm.nih.gov/8652809
Autor:
Te, Warkentin, Catherine Hayward, Lk, Boshkov, Av, Santos, Ja, Sheppard, Ap, Bode, Jg, Kelton
Publikováno v:
Europe PubMed Central
Heparin-induced thrombocytopenia is characterized by moderate thrombocytopenia and thrombotic complications, whereas quinine/quinidine-induced thrombocytopenia usually presents with severe thrombocytopenia and bleeding. Using flow cytometry and assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2020ff1466c674cdfdf2fa2183c85dd
https://pubmed.ncbi.nlm.nih.gov/7949124
https://pubmed.ncbi.nlm.nih.gov/7949124
Publikováno v:
Europe PubMed Central
Antiplatelet antibodies can activate platelets causing platelet aggregation and the release reaction. However, the pathway of activation by these antibodies is unknown and several potential mechanisms are possible. In this report, we describe studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0edebd07f9c13d78141d888b43b9d23
https://pubmed.ncbi.nlm.nih.gov/1714324
https://pubmed.ncbi.nlm.nih.gov/1714324
Publikováno v:
Europe PubMed Central
Platelets contain proteins with biochemical properties that are well adapted to promoting hemostasis. One important adhesive protein is von Willebrand factor (vWF), which is a very large protein comprised of a series of multimers, ranging from 860,00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bd38acf863d2815f3b5c9839a329a6
https://pubmed.ncbi.nlm.nih.gov/2043761
https://pubmed.ncbi.nlm.nih.gov/2043761
Publikováno v:
Europe PubMed Central
Platelets respond to a large number of stimuli by undergoing complex biochemical and morphological changes. These changes are involved in physiological processes including adhesion, aggregation, and coagulation. Platelet activation produces membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::59c92c71ebe345384aef2755b9811bf5
https://pubmed.ncbi.nlm.nih.gov/2016319
https://pubmed.ncbi.nlm.nih.gov/2016319