Zobrazeno 1 - 10
of 59
pro vyhledávání: '"JEONGKYUNG LEE"'
Autor:
Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana M. Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cells, Vol 13, Iss 13, p 1108 (2024)
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D. Epigenetic modulators suc
Externí odkaz:
https://doaj.org/article/4352056514b0436c91865b24cc85dd4b
Autor:
Feng Li, Ruya Liu, Vinny Negi, Ping Yang, Jeongkyung Lee, Rajaganapathi Jagannathan, Mousumi Moulik, Vijay K. Yechoor
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111904- (2023)
Summary: TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized. In this study, we demonstrate that while β cell-specific TEAD1 deletion results i
Externí odkaz:
https://doaj.org/article/58507afec47146c5b6c53a63b91d1ced
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/80a9316234f0489ea6aac13c81dc27be
Autor:
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104771- (2022)
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets
Externí odkaz:
https://doaj.org/article/073b353a30d149d4b39ba15b63d8a932
Autor:
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly impl
Externí odkaz:
https://doaj.org/article/b9206d5d35df46e48ee2e0a5e574828b
Autor:
Ruya Liu, Rajaganapathi Jagannathan, Feng Li, Jeongkyung Lee, Nikhil Balasubramanyam, Byung S Kim, Ping Yang, Vijay K Yechoor, Mousumi Moulik
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212017 (2019)
Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and perinatal period, as adult cardiomyocyte proliferation is restricted in comparison to that seen d
Externí odkaz:
https://doaj.org/article/95b43d1709ae4f218ddab65b196a37bf
Autor:
Sayali S Dixit, Tiannan Wang, Eiffel John Q Manzano, Shin Yoo, Jeongkyung Lee, David Y Chiang, Nicole Ryan, Jonathan L Respress, Vijay K Yechoor, Xander H T Wehrens
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58655 (2013)
Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca(2+)-handling in pancreatic β cells. Insulin secretion is triggered by elevation in cytoplasmic Ca(2+) concentra
Externí odkaz:
https://doaj.org/article/f3c2db051af7458d94e52953cbbd860d
Publikováno v:
bioRxiv
The circadian clock machinery exerts transcriptional control to modulate adipogenesis and its disruption leads to the development of obesity. Here we report that Nobiletin, a clock amplitude-enhancing molecule, displays anti-adipogenic properties via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbc29687ff8f4c7775b5f1e02f3e10e
https://doi.org/10.1101/2023.02.07.527587
https://doi.org/10.1101/2023.02.07.527587
Publikováno v:
Nucleic Acids Res
The Hippo-TEAD pathway regulates cellular proliferation and function. The existing paradigm is that TEAD co-activators, YAP and TAZ, and co-repressor, VGLL4, bind to the pocket region of TEAD1 to enable transcriptional activation or repressive functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c2cf4dc753461a7c9f0bbe03cb7217
https://pubmed.ncbi.nlm.nih.gov/36484096
https://pubmed.ncbi.nlm.nih.gov/36484096
Autor:
DESPOINA ASLANOGLOU, SUZANNE BERTERA, LAURA FRIGGERI, MARTA SANCHEZ SOTO, JEONGKYUNG LEE, XIANGNING XUE, RYAN LOGAN, ROB LANE, VIJAY YECHOOR, R BENJAMIN FREE, DAVID R. SIBLEY, RITA BOTTINO, ZACHARY FREYBERG
Publikováno v:
Diabetes. 71
Dopaminergic agonism effectively treats dysglycemia, with dopaminergic agonist bromocriptine approved as a type 2 diabetes therapy. Though bromocriptine’s actions have been mainly attributed to stimulation of dopamine D2 receptors (D2R) in the brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9bb1a86da12ce847866230945ac1232
https://doi.org/10.2337/db22-1472-p
https://doi.org/10.2337/db22-1472-p