Zobrazeno 1 - 10
of 28
pro vyhledávání: '"JENNIFER F. O'CONNELL"'
Autor:
Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F. O’Connell, Isabel González-Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M. Egan, Máire E. Doyle
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101917- (2024)
Externí odkaz:
https://doaj.org/article/fc2998fbbee947e0b1e63770929e59bb
Autor:
Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F. O’Connell, Isabel González-Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M. Egan, Máire E. Doyle
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101906- (2024)
Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that geneti
Externí odkaz:
https://doaj.org/article/f9b137e5ebbd4b2fba8b127ac6e303d3
Publikováno v:
Biology, Vol 13, Iss 1, p 36 (2024)
Cellular senescence is defined as an irreversible cell cycle arrest accompanied by morphological and physiological alterations during aging. Red ginseng (RG), processed from fresh ginseng (Panax ginseng C.A. Meyer) with a one-time steaming and drying
Externí odkaz:
https://doaj.org/article/d6fb219b40ee41978519e844b6b1404a
Autor:
Da-Yeon Lee, Su-Jeong Lee, Prabha Chandrasekaran, Gopal Lamichhane, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1165 (2023)
Dietary interventions with bioactive compounds have been found to suppress the accumulation of senescent cells and senescence-associated secretory phenotypes (SASPs). One such compound, curcumin (CUR), has beneficial health and biological effects, in
Externí odkaz:
https://doaj.org/article/d8be756d22cc4745a4108e74df252f51
Autor:
Yoo Kim, Sudeep Gautam, Kanikkai Raja Aseer, Jaekwan Kim, Prabha Chandrasekaran, Caio Henrique Mazucanti, Paritosh Ghosh, Jennifer F. O’Connell, Máire E. Doyle, Ashley Appleton, Elin Lehrmann, Qing-Rong Liu, Josephine M. Egan
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-13 (2020)
Abstract Cannabinoid 1 receptor (CB1R) expression is upregulated in the liver with viral hepatitis, cirrhosis, and both alcoholic and non-alcoholic fatty liver disease (FLD), whereas its expression is muted under usual physiological conditions. Inhib
Externí odkaz:
https://doaj.org/article/9666fd9589f04fc68c08c674919873b5
Autor:
Qing-Rong Liu, Kanikkai Raja Aseer, Qin Yao, Xiaoming Zhong, Paritosh Ghosh, Jennifer F. O’Connell, Josephine M. Egan
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from loss of insulin-secreting β-cells in islets of Langerhans. The loss of β-cells is initiated when self-tolerance to β-cell-derived contents breaks down, which leads to T cell-m
Externí odkaz:
https://doaj.org/article/72eb20ce937f45c88093881f016d9ad4
Publikováno v:
Biology, Vol 11, Iss 8, p 1108 (2022)
Cellular senescence, one of the hallmarks of aging, refers to permanent cell cycle arrest and is accelerated during the aging process. Black ginseng (BG), prepared by a repeated steaming and drying process nine times from fresh ginseng (Panax ginseng
Externí odkaz:
https://doaj.org/article/268878944b09474c828b2e387125421d
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction significantly contribute
Externí odkaz:
https://doaj.org/article/435cd482ff914ee38c0f7a1f1c6ad827
Autor:
Su-Jeong Lee, Prabha Chandrasekran, Caio Henrique Mazucanti, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim
Publikováno v:
Aging (Albany NY)
Although aging is a physiological process to which all organisms are subject, the presence of obesity and type 2 diabetes accelerates biological aging. Recent studies have demonstrated the causal relationships between dietary interventions suppressin
Autor:
CAIO MAZUCANTI, VERNON L. KENNEDY, ANDREW CHO, QING-RONG LIU, JENNIFER F. O’CONNELL, SIMONETTA CAMANDOLA, JOSEPHINE M. EGAN
Publikováno v:
Diabetes. 71
The insulin receptor (IR) is a tyrosine kinase receptor present in cell membranes. It is highly expressed in hepatocytes (where it promotes glycogenesis and inhibits gluconeogenesis) , and skeletal muscle and fat (where it facilitates glucose uptake