Zobrazeno 1 - 8
of 8
pro vyhledávání: '"JEGADEESAN VAIGUNDA RAGAVENDRAN"'
Publikováno v:
Recent Patents on CNS Drug Discovery. 1:113-118
GABA (gamma-aminobutyric acid) is one of the major inhibitory transmitters in the central nervous system of mammals. GABA is not transported efficiently into the brain from the bloodstream (i.e. GABA does not effectively cross the blood-brain barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e597415aa9dbeb16692cae8faf3dc820
https://doi.org/10.2174/1574889810601010113
https://doi.org/10.2174/1574889810601010113
Autor:
Perumal Yogeeswari, Ramkumar Kavya, Jegadeesan Vaigunda Ragavendran, Yarravarapu Nageswari, Dharmarajan Sriram, James Stables, Kaliappan Vanitha, Narayanan Sreevatsan
Publikováno v:
Journal of Medicinal Chemistry. 50:2459-2467
Antiepileptic drugs are often utilized in the treatment of neuropathic pain. The present study aims at the design and synthesis of newer gamma-aminobutyric acid (GABA) derivatives with the combination of aryl semicarbazone and the GABA pharmacophores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b295ec2fda08c34014efd6ad31fb09
https://doi.org/10.1021/jm061431g
https://doi.org/10.1021/jm061431g
Autor:
Perumal Yogeeswari, Ingala Vikram Reddy, James P. Stables, Sravan Kumar Patel, Jegadeesan Vaigunda Ragavendran, Narayanan Bharathwajan, Dharmarajan Sriram
Publikováno v:
European Journal of Medicinal Chemistry. 42:146-151
Two series of pharmacophoric hybrids of phthalimide-GABA-anilides/hydrazones were designed and synthesized and evaluated for their anticonvulsant and neurotoxic properties. The structures of the synthesized compounds were confirmed by the use of thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc76b3d131ae6383185f656b8efc643
https://doi.org/10.1016/j.ejmech.2006.08.010
https://doi.org/10.1016/j.ejmech.2006.08.010
Autor:
Perumal, Yogeeswari, Dharmarajan, Sriram, Rathinasabapathy, Thirumurugan, Logantha Ramamoorthy, Jeewanlal, Sunil, Jit, Jegadeesan Vaigunda, Ragavendran, Ramkumar, Kavya, Kavya, Rakhra, Vivek, Saraswat
Publikováno v:
Acta pharmaceutica (Zagreb, Croatia). 56(3)
Several 2,4-dimethylphenyl substituted semicarbazones were synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures were confirmed by spectral and elemental analyses. All the compounds were evaluated for anticon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48fee0cb6465ff7f8bb3d03884c09c9c
https://pubmed.ncbi.nlm.nih.gov/19831276
https://pubmed.ncbi.nlm.nih.gov/19831276
Autor:
Jegadeesan Vaigunda Ragavendran, Puppala Sahitya, Perumal Yogeeswari, Velagaleti Ranganadh, Dharmarajan Sriram
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
A series of pharmacophoric hybrids of ameltolide-γ-aminobutyric acid (GABA)-amides was designed, synthesized, and evaluated for their anticonvulsant and neurotoxic properties. Initial anticonvulsant screening was performed using intraperitoneal (ip)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b6b823ec4210a619287358ddb8e3c0
https://pubmed.ncbi.nlm.nih.gov/17481896
https://pubmed.ncbi.nlm.nih.gov/17481896
Autor:
Perumal Yogeeswari, Harshini Neelakantan, Jegadeesan Vaigunda Ragavendran, Kaliappan Vanitha, Ramkumar Kavya, Dharmarajan Sriram
Publikováno v:
Pharmacology. 81(1)
Background: There is considerable research evidence supporting a palliative role for γ-aminobutyric acid (GABA)-ergic neurotransmission and voltage-gated sodium channel blockade in neuropathic pain conditions. Hence, the present study was undertaken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f5977ac75566503a024df1b66c92b7
https://pubmed.ncbi.nlm.nih.gov/17785996
https://pubmed.ncbi.nlm.nih.gov/17785996
Autor:
Perumal Yogeeswari, Jegadeesan Vaigunda Ragavendran, S. Induja, J. P. Stables, Rathinasabapathy Thirumurugan, Dharmarajan Sriram
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 2(1)
Seven series of various substituted aryl semicarbazones were synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure threshold tests. A comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b8d23abac8461a2faa6db223661542
https://pubmed.ncbi.nlm.nih.gov/16787356
https://pubmed.ncbi.nlm.nih.gov/16787356
Autor:
PERUMAL YOGEESWARI, DHARMARAJAN SRIRAM, RATHINASABAPATHY THIRUMURUGAN, LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT, JEGADEESAN VAIGUNDA RAGAVENDRAN, RAMKUMAR KAVYA, KAVYA RAKHRA, VIVEK SARASWAT
Publikováno v:
Acta Pharmaceutica
Volume 56
Issue 3
Volume 56
Issue 3
Several 2,4-dimethylphenyl substituted semicarbazones were synthesized in three steps involving aryl urea and aryl semicarbazide formations. The structures were confirmed by spectral and elemental analyses. All the compounds were evaluated for antico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______951::1f838444a825f5efd4772a1344ca97ab
https://hrcak.srce.hr/file/7415
https://hrcak.srce.hr/file/7415