Zobrazeno 1 - 10
of 63
pro vyhledávání: '"JEFFREY M. STADEL"'
Autor:
Jeffrey M. Stadel, Henry M. Sarau, Shelagh Wilson, Jeffrey S. Culp, Brian D. Hellmig, James J. Foley, Janet Park, Alison I. Muir, Jon K. Chambers, Robert S. Ames, J. Randall Slemmon, Dean E. McNulty, Derk J. Bergsma
Publikováno v:
G Protein-Coupled Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b48a2934c1ac3991b17c7c9fc6b9365
https://doi.org/10.1201/9780429129377-4
https://doi.org/10.1201/9780429129377-4
Autor:
Anne M. Romanic, Douglas W. P. Hay, Shelagh Wilson, Eliot H. Ohlstein, Nambi Aiyar, Calvert Louden, Wu-Schyong Liu, Henry M. Sarau, George I. Glover, Stephen A. Douglas, Stephen Dudley Holmes, Charles F. Sauermelch, Nabil Elshourbagy, Usman Shabon, John D. Martin, Robert W. Coatney, James J. Foley, Johathan K. Chambers, Derk J. Bergsma, Catherine E. Ellis, Dean E. McNulty, Robert S. Ames, John J. Trill, Zhaohui Ao, Robert N. Willette, Jeffrey M. Stadel, Jyoti Disa
Publikováno v:
Nature. 401:282-286
Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords1,2, and which has recently been cloned from man3. Here we describe the identification of an orphan human G-protein-coupled
Autor:
Donna S. Woulfe, Jeffrey M. Stadel
Publikováno v:
Journal of Biological Chemistry. 274:17718-17724
GAIP is a regulator of G protein signaling (RGS) that accelerates the rate of GTP hydrolysis by some G protein α subunits. In the present studies, we have examined the structural basis for the ability of GAIP to discriminate among members of the Gα
Publikováno v:
Molecular and Cellular Biochemistry. 197:179-185
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse biological properties including potent vasodilating activity. Recently, we reported the cloning of complementary DNAs (cDNAs) encoding the human and porcine CGRP receptors which sh
Autor:
Nicole C. Herrity, Catherine E. Ellis, Alison I. Muir, Jeffrey M. Stadel, Jon K. Chambers, Shelagh Wilson, Paul R. Murdock, Kenneth G. M. Fantom, Derk J. Bergsma
Publikováno v:
British Journal of Pharmacology. 125:1387-1392
The pharmaceutical industry has readily embraced genomics to provide it with new targets for drug discovery. Large scale DNA sequencing has allowed the identification of a plethora of DNA sequences distantly related to known G protein-coupled recepto
Autor:
Richard M. Keenan, Steven T. Ross, M. Amparo Lago, S M Hwang, Eliot H. Ohlstein, Tian-Li Yue, David J. Rieman, Chet Kwon, Fadia E. Ali, Brian R. Smith, Lynne Vickery, Thomas T. Nguyen, Dalia R. Jakas, Russell D. Cousins, Calvert Louden, Jeffrey M. Stadel, Leon B. Hall, James Samanen, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3171-3176
In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and i.v. pharmacokinetics for demonstrati
Publikováno v:
Trends in Pharmacological Sciences. 19:243-247
the activity of the effector in theabsence of exogenous agonist.Although several hundred GPCRsand more than a dozen different Gproteins have been cloned thus far,the interaction of a GPCR with its G protein(s) can be modelled byassuming that the rece
Autor:
Kodandaram Pillarisetti, Shalley K. Gupta, Eliot H. Ohlstein, Paul G. Lysko, Jeffrey M. Stadel
Publikováno v:
Journal of Biological Chemistry. 273:4282-4287
Chemokines play an important role in the regulation of endothelial cell (EC) function, including proliferation, migration and differentiation during angiogenesis, and re-endothelialization after injury. In this study, reverse transcriptase-polymerase
Publikováno v:
Trends in Pharmacological Sciences. 18:430-437
Access to DNA databases has introduced an exciting new dimension to the way biomedical research is conducted. `Genomic research' offers tremendous opportunity for accelerating the identification of the cause of disease at the molecular level and ther