Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days

Autor: Maodo Malick Diop, Shim-mo Hayashi, Mark R. Bauter, Jan Demyttenaere, Sean V. Taylor, Christie L. Harman, Gerhard Krammer, Odete Mendes, Jürgen Schnabel, Maria Bastaki, Michel Aubanel, Vivian Lu, Thierry Cachet, A.M. Api, Kevin J. Renskers

Publikováno v: Current Research in Toxicology
Current Research in Toxicology, Vol 2, Iss, Pp 192-201 (2021)

Graphical abstract
Highlights • GLP-compliant 90-day study on β-ionone epoxide following OECD guideline. • β-Ionone epoxide produces no adverse effects at doses up to 80 mg/kg bw/day in rats. • β-Ionone epoxide had no effect on reproduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a1734febce3f0eddc6953294b37beb
https://doi.org/10.1016/j.crtox.2021.05.001

Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19

Autor: Ana Teresa Serra, Tatiana Emanuelli, Greicy M.M. Conterato, Inês Prazeres, Maria Rosário Bronze, Paula Rossini Augusti, Cristiane Casagrande Denardin

Publikováno v: The Journal of Nutritional Biochemistry

The outbreak of mysterious pneumonia at the end of 2019 is associated with widespread research interest worldwide. The coronavirus disease-19 (COVID-19) targets multiple organs through inflammatory, immune, and redox mechanisms, and no effective drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e1f86065b6f84ce9d71fec1d97bb6f
https://doi.org/10.1016/j.jnutbio.2021.108787

Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential

Autor: Kazuhiko Saigo, Shim-mo Hayashi, Cheryl A. Hobbs, Mihoko Koyanagi

Publikováno v: Toxicology Reports, Vol 4, Iss, Pp 554-559 (2017)
Toxicology Reports

Graphical abstract
Highlights • Magnesium stearate is widely used as a food additive. • No published data available related to magnesium stearate genotoxic potential. • Magnesium stearate was evaluated in a battery of genetic toxicity test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557de33a57bc56f1792031acbfff7651
http://www.sciencedirect.com/science/article/pii/S2214750017300707

Hydrolytic fate of deoxynivalenol-3-glucoside during digestion

Autor: Rudolf Krska, Gerhard Adam, Franz Berthiller, Wolfgang Kneifel, Rainer Schuhmacher, Nathalie Juge, Konrad J. Domig

Publikováno v: Toxicology Letters

Highlights ► Deoxynivalenol-3-glucoside (D3G) is hydrolyzed to deoxynivalenol during digestion. ► D3G is resistant to acids and enzymes expressed by humans. ► D3G is partly cleaved by cellulase and cellobiase. ► Several intestinal bacteria li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2bab6f66f63a499f46af6789d35fbf
https://doi.org/10.1016/j.toxlet.2011.08.006

Dietary administration of β -ionone epoxide to Sprague-Dawley rats for 90 days.

Autor: Lu V; International Organization of the Flavor Industry, 1101 17th Street NW, Suite 700, Washington, DC 20036, USA., Bastaki M; International Organization of the Flavor Industry, 1101 17th Street NW, Suite 700, Washington, DC 20036, USA., Api AM; Research Institute for Fragrance Materials, Inc., 50 Tice Blvd., Woodcliff Lake, NJ 07677, USA., Aubanel M; Kerry Flavours France, Zl du Plan BP 82067, 63 Avenue Jean Maubert, 06131 Grasse Cedex, France., Bauter M; Product Safety Labs, 2394 US Route 130, Dayton, NJ 08810, USA., Cachet T; International Organization of the Flavor Industry, Avenue des Arts 6, B-1210 Brussels, Belgium., Demyttenaere J; European Flavour Association, Avenue des Arts 6, B-1210 Brussels, Belgium., Diop MM; V. Mane Fils, 620 Route de Grasse, 06620 Le Bar-sur-Loup, France., Harman CL; Flavor and Extract Manufacturers Association, 1101 17th Street NW, Suite 700, Washington, DC 20036, USA., Hayashi SM; Japan Flavor and Fragrance Materials Association, Sankeinihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo, 103-0023, Japan., Krammer G; Symrise AG, Muhlenfeldstrasse 1, 37603 Holzminden, Germany., Mendes O; Product Safety Labs, 2394 US Route 130, Dayton, NJ 08810, USA., Renskers KJ; Takasago International Corporation, 4 Volvo Drive, PO Box 932, Rockleigh, NJ 07647, USA., Schnabel J; Givaudan International SA, Kemptpark 50, 8310 Kemptthal, Switzerland., Taylor SV; International Organization of the Flavor Industry, 1101 17th Street NW, Suite 700, Washington, DC 20036, USA.

Publikováno v: Current research in toxicology [Curr Res Toxicol] 2021 May 18; Vol. 2, pp. 192-201. Date of Electronic Publication: 2021 May 18 (Print Publication: 2021).