Zobrazeno 1 - 10
of 289
pro vyhledávání: '"JEAN-PHILIPPE LOEFFLER"'
Autor:
Laura Le Gall, William J. Duddy, Cecile Martinat, Virginie Mariot, Owen Connolly, Vanessa Milla, Ekene Anakor, Zamalou G. Ouandaogo, Stephanie Millecamps, Jeanne Lainé, Udaya Geetha Vijayakumar, Susan Knoblach, Cedric Raoul, Olivier Lucas, Jean Philippe Loeffler, Peter Bede, Anthony Behin, Helene Blasco, Gaelle Bruneteau, Maria Del Mar Amador, David Devos, Alexandre Henriques, Adele Hesters, Lucette Lacomblez, Pascal Laforet, Timothee Langlet, Pascal Leblanc, Nadine Le Forestier, Thierry Maisonobe, Vincent Meininger, Laura Robelin, Francois Salachas, Tanya Stojkovic, Giorgia Querin, Julie Dumonceaux, Gillian Butler Browne, Jose‐Luis González De Aguilar, Stephanie Duguez, Pierre Francois Pradat
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1385-1402 (2022)
Abstract Background The cause of the motor neuron (MN) death that drives terminal pathology in amyotrophic lateral sclerosis (ALS) remains unknown, and it is thought that the cellular environment of the MN may play a key role in MN survival. Several
Externí odkaz:
https://doaj.org/article/261a53bffa414819a14cb82060834ea9
Autor:
Robin Waegaert, Sylvie Dirrig-Grosch, Haoyi Liu, Marion Boutry, Ping Luan, Jean-Philippe Loeffler, Frédérique René
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 497 (2022)
CHMP2B is a protein that coordinates membrane scission events as a core component of the ESCRT machinery. Mutations in CHMP2B are an uncommon cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative diseas
Externí odkaz:
https://doaj.org/article/70e714f51bd5447c8cc1653382503178
Autor:
Silvia Scaricamazza, Illari Salvatori, Giacomo Giacovazzo, Jean Philippe Loeffler, Frederique Renè, Marco Rosina, Cyril Quessada, Daisy Proietti, Constantin Heil, Simona Rossi, Stefania Battistini, Fabio Giannini, Nila Volpi, Frederik J. Steyn, Shyuan T. Ngo, Elisabetta Ferraro, Luca Madaro, Roberto Coccurello, Cristiana Valle, Alberto Ferri
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Patients with ALS show, in addition to the loss of motor neurons in the spinal cord, brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside hypermetabolism. In this study, we show that bioenergetic defects and muscl
Externí odkaz:
https://doaj.org/article/93e692a5f29146c4b56df3efb45dd920
Autor:
Robin Waegaert, Sylvie Dirrig-Grosch, Florian Parisot, Céline Keime, Alexandre Henriques, Jean-Philippe Loeffler, Frédérique René
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104710- (2020)
Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with currently no cure. These two diseases share a clinical continuum with overlapping genetic causes. Mutations in the CHMP2B gene are found in patients wit
Externí odkaz:
https://doaj.org/article/889466d7b8d340a2a6458e0cb99c65fb
Autor:
Cyril Quessada, Alexandra Bouscary, Frédérique René, Cristiana Valle, Alberto Ferri, Shyuan T. Ngo, Jean-Philippe Loeffler
Publikováno v:
Cells, Vol 10, Iss 6, p 1449 (2021)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive and selective loss of motor neurons, amyotrophy and skeletal muscle paralysis usually leading to death due to respiratory failure. While generally c
Externí odkaz:
https://doaj.org/article/1ff75d87f09b464fb571e9ffe82233a0
Autor:
Alexandre Henriques, Mylene Huebecker, Hélène Blasco, Céline Keime, Christian R. Andres, Philippe Corcia, David A. Priestman, Frances M. Platt, Michael Spedding, Jean-Philippe Loeffler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and glucosylceramide, to neurodegeneration and to motor unit dismantling in amyotrophic lateral sclerosis at late disease stage. We report here alt
Externí odkaz:
https://doaj.org/article/8a113634c1bc4f8e9982c0d7c16ccc59
Autor:
Alexandra Bouscary, Cyril Quessada, Althéa Mosbach, Noëlle Callizot, Michael Spedding, Jean-Philippe Loeffler, Alexandre Henriques
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Amyotrophic lateral sclerosis (ALS) is a multifactorial and fatal neurodegenerative disease. Growing evidence connects sphingolipid metabolism to the pathophysiology of ALS. In particular, levels of ceramides, glucosylceramides, and gangliosides are
Externí odkaz:
https://doaj.org/article/337e1ace11764decac5e777520b50712
Autor:
Christian Gaiddon, Jean-Philippe Loeffler, Michel Pfeffer, Claude Sirlin, Pierre Bischoff, Pauline Wlosik, Anne Boos, Pascal Hébraud, Sébastien Harlepp, Bastien Fricker, Samir Benosman, Isabelle Gross, Marjorie Jenny, Mili L. Leyva, Xiangjun Meng
Supplementary Methods from A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9d87ba20164106433f5df8c59f6500
https://doi.org/10.1158/0008-5472.22378553
https://doi.org/10.1158/0008-5472.22378553
Autor:
Christian Gaiddon, Jean-Philippe Loeffler, Michel Pfeffer, Claude Sirlin, Pierre Bischoff, Pauline Wlosik, Anne Boos, Pascal Hébraud, Sébastien Harlepp, Bastien Fricker, Samir Benosman, Isabelle Gross, Marjorie Jenny, Mili L. Leyva, Xiangjun Meng
Supplementary Figure 3 from A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d0a3ad7c540a994e052cbc96fa8ec9
https://doi.org/10.1158/0008-5472.22378559.v1
https://doi.org/10.1158/0008-5472.22378559.v1
Autor:
Christian Gaiddon, Jean-Philippe Loeffler, Michel Pfeffer, Claude Sirlin, Pierre Bischoff, Pauline Wlosik, Anne Boos, Pascal Hébraud, Sébastien Harlepp, Bastien Fricker, Samir Benosman, Isabelle Gross, Marjorie Jenny, Mili L. Leyva, Xiangjun Meng
Supplementary Figure 4 from A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a57c94dc87e73ca83f9b0bb26dde7a
https://doi.org/10.1158/0008-5472.22378556
https://doi.org/10.1158/0008-5472.22378556