Zobrazeno 1 - 10
of 189
pro vyhledávání: '"JE Visvader"'
Autor:
Maria Joao Silva, Mark Rosenthal, Alice Ruth Bergin, Andrew W. Roberts, Daniel H.D. Gray, GB Mann, D Liew, Jayesh Desai, Kylie Shackleton, Anand Murugasu, GJ Lindeman, Sheau Wen Lok, François Vaillant, James R. Whittle, S-J Dawson, C Teh, Avraham Travers, Peter Sherman, Zhen Rong Siow, JE Visvader
Publikováno v:
Cancer Research. 79:PD1-06
Background: Venetoclax, a potent and selective inhibitor of the survival protein BCL-2 (recently approved in CLL and in development in other hematopoietic malignancies), has yet to be evaluated in pts with solid tumors. BCL-2 is overexpressed in ˜85
Autor:
N Lalaoui, Merino, Delphine, G Giner, F Vaillant, D Chau, L Liu, T Kratina, Pal, Bhupinder, JR Whittle, Etemadi, Nima, Berthelet, Jean, J Gräsel, C Hall, ME Ritchie, Ernst, Matthias, GK Smyth, Vaux, David, JE Visvader, GJ Lindeman, Silke, John
© 2020, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare. Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Here we have evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf501fb6b8f40ba466b0d0b8ffb3017
Autor:
Bhupinder Pal, Gordon K. Smyth, JE Visvader, François Vaillant, Sheau Wen Lok, Göknur Giner, Emma Nolan, Kylie Shackleton, Lachlan Whitehead, GB Mann, GJ Lindeman
Publikováno v:
Cancer Research. 76:P3-11
Background: BRCA1 mutation carriers often undergo prophylactic mastectomy to minimize their risk of breast cancer. The value of targeting ovarian hormones to prevent breast tumorigenesis remains contentious and the identification of an effective and
Autor:
GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, Consortium kConFab, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader
Publikováno v:
Cancer Research. 77:S2-04
Background: BRCA1 mutation carriers commonly undergo prophylactic mastectomy to reduce their risk of breast cancer. The precise role of chemoprevention with tamoxifen, which reduces the incidence of ER-positive breast cancer in the general population
Autor:
JE Visvader, Geoff Lindeman
Publikováno v:
Cancer Research. 80:BL1-BL1
Breast cancer is a highly heterogeneous disease at the molecular and pathological levels. To understand heterogeneity and potential ‘cells of origin’ of breast cancer, it is important to dissect the normal mammary epithelial differentiation hiera
Autor:
Daniel H.D. Gray, Kevin H. Liu, GJ Lindeman, François Vaillant, Bhupinder Pal, Antonia N. Policheni, James R. Whittle, JE Visvader, Gordon K. Smyth, CE Caldon, Göknur Giner, K Fernandez
Publikováno v:
Cancer Research. 79:PD7-07
Background: Despite incremental advances in chemotherapy and endocrine therapy, survival outcomes for patients with ER-positive (ER+) metastatic breast cancer (MBC) remain poor. The majority of relapsing tumors exhibit deregulation of the cyclin-depe
Autor:
Louisa J. Phillipson, Matthew E. Ritchie, Lily Lee, Bhupinder Pal, François Vaillant, Gordon K. Smyth, GB Mann, Delphine Merino, Christopher J. Burns, JE Visvader, GJ Lindeman, Michael Christie, Kelsey Breslin
Publikováno v:
Cancer Research. 73:P2-09
Background: Impairment of apoptosis is a hallmark of cancer and can result in resistance to therapy. Over-expression of the pro-survival protein BCL-2 is common in breast cancer, with elevated levels found in approximately 85% of luminal tumors. Alth
Autor:
François Vaillant, William C. Dougall, R Soriano, GB Mann, GJ Lindeman, JE Visvader, D Branstetter
Publikováno v:
Cancer Research. 73:P5-03
Background: Breast tumors in BRCA1 mutation carriers likely arise from luminal progenitor (LP) cells, previously shown to exhibit aberrant growth properties. Oophorectomy, and possibly tamoxifen, reduce breast cancer risk in BRCA1 carriers, potential
Autor:
JE Visvader, Elgene Lim, François Vaillant, Stephen B. Fox, Elena A Takano, Frank Feleppa, Teresa Ward, Dcs Huang, Gordon K. Smyth, Lily Lee, Matthew E. Ritchie, Kelsey Breslin, S. Deb, Samantha R. Oakes, Andreas Strasser, GJ Lindeman, Daniele Generali
Publikováno v:
Cancer Research. 71:PD08-02
Background: Impairment of apoptosis is a hallmark of cancer and can result in resistance to chemotherapy. Tumor resistance to apoptosis is frequently acquired through deregulated expression of BCL-2 family members or inactivation of the p53 tumor sup
Autor:
JE Visvader, GJ Lindeman, M-L Asselin-Labat, Toula Bouras, Hideo Yagita, Bhupinder Pal, Gordon K. Smyth, François Vaillant, Di Wu, Elgene Lim
Publikováno v:
Cancer Research. 70:P4-04
INTRODUCTION: Molecular characterization of the normal epithelial cell types that reside in the mammary gland is an important step toward understanding pathways that regulate self-renewal, lineage commitment, and differentiation along the hierarchy.