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Qualification of Source Test Methods as Reference Methods

Autor: RN Pesut, JE Howes

Air pollution measurements require test methods that have a demonstrated capability to yield reliable data when the procedures are carried out by people with different backgrounds and experience. Collaborative testing canprovide "real world" situatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c42357981bf03620952b8c724db882bd
https://doi.org/10.1520/stp32356s

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Akademický článek

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.

Autor: Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States., Stauffer SR; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States., Fesik SW; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Dec 26; Vol. 62 (24), pp. 11232-11259. Date of Electronic Publication: 2019 Dec 05.

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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.

Autor: Akan DT; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Howes JE; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Sai J; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Arnold AL; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Beesetty Y; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Phan J; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Olejniczak ET; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Waterson AG; Department of Pharmacology , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States.; Department of Chemistry , Vanderbilt University , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States., Fesik SW; Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States.; Department of Pharmacology , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States.; Department of Chemistry , Vanderbilt University , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2019 Mar 15; Vol. 14 (3), pp. 325-331. Date of Electronic Publication: 2019 Feb 18.

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Akademický článek

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

Autor: Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D; Boehringer Ingelheim RCV GmbH & Co. KG , Doktor-Boehringer-Gasse 5-11 , 1120 Vienna , Austria., Stadtmueller H; Boehringer Ingelheim RCV GmbH & Co. KG , Doktor-Boehringer-Gasse 5-11 , 1120 Vienna , Austria., Rossanese OW, Phan J, Waterson AG; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232-0146 , United States., McConnell DB; Boehringer Ingelheim RCV GmbH & Co. KG , Doktor-Boehringer-Gasse 5-11 , 1120 Vienna , Austria., Fesik SW; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232-0146 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Oct 11; Vol. 61 (19), pp. 8875-8894. Date of Electronic Publication: 2018 Sep 28.

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Akademický článek

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

Autor: Abbott JR; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Patel PA; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Howes JE; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Akan DT; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Kennedy JP; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Burns MC; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Browning CF; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Sun Q; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Rossanese OW; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Phan J; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Waterson AG; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0146, United States., Fesik SW; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.; Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0146, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Aug 08; Vol. 9 (9), pp. 941-946. Date of Electronic Publication: 2018 Aug 08 (Print Publication: 2018).

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Akademický článek

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

Autor: Abbott JR, Hodges TR, Daniels RN, Patel PA, Kennedy JP, Howes JE, Akan DT, Burns MC, Sai J, Sobolik T, Beesetty Y, Lee T, Rossanese OW, Phan J, Waterson AG; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232-0146 , United States., Fesik SW; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232-0146 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jul 26; Vol. 61 (14), pp. 6002-6017. Date of Electronic Publication: 2018 Jul 11.

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Akademický článek

Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.

Autor: Howes JE; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee., Akan DT; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee., Burns MC; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee., Rossanese OW; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee., Waterson AG; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee., Fesik SW; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee. stephen.fesik@vanderbilt.edu.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2018 May; Vol. 17 (5), pp. 1051-1060. Date of Electronic Publication: 2018 Feb 13.

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Akademický článek

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.

Autor: Burns MC; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Howes JE; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Sun Q; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Little AJ; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Camper DV; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Abbott JR; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Phan J; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Lee T; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Waterson AG; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Rossanese OW; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA., Fesik SW; Vanderbilt University School of Medicine, Department of Biochemistry, 2215 Garland Ave., 607 Light Hall, Nashville, TN, 37232-0146, USA. Electronic address: stephen.fesik@vanderbilt.edu.

Publikováno v: Analytical biochemistry [Anal Biochem] 2018 May 01; Vol. 548, pp. 44-52. Date of Electronic Publication: 2018 Feb 11.

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