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Abstract P2-09-15: NTRK fusions in breast cancer: Clinical, pathologic and genomic findings

Autor: JS Ross, J Chung, JE Elvin, J-A Vergilio, S Ramkissoon, J Suh, E Severson, S Daniel, GM Frampton, D Fabrizio, RJ Hartmaier, LA Albacker, SM Ali, AB Schrock, VA Miller, PJ Stephens, LM Gay

Publikováno v: Cancer Research. 78:P2-09

Background: The tropomysin receptor kinase A family includes the 3 NTRK1, NTRK2 and NTRK3 genes and plays major roles in neuronal development. The recent evidence of remarkable efficacy for kinase inhibitors (TKI) targeting NTRK across a wide variety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4b8073a0a60f01beaf32cf13a2c573e
https://doi.org/10.1158/1538-7445.sabcs17-p2-09-15

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Abstract PD8-01: CDH1 mutated classic and pleomorphic invasive lobular breast carcinomas differ in genomic signatures and opportunities for targeted and immunotherapies

Autor: JS Ross, J Chung, JE Elvin, J-A Vergilio, S Ramkissoon, J Suh, E Severson, S Daniel, GM Frampton, D Fabrizio, RJ Hartmaier, LA Albacker, SM Ali, AB Schrock, VA Miller, PJ Stephens, LM Gay

Publikováno v: Cancer Research. 78:PD8-01

Background: Typically defined by negative IHC staining for E-cadherin, classic (CILC) and pleomorphic (PILC) are often combined as a single breast cancer subtype. We queried whether patients with relapsed metastatic disease, mCILC and mPILC, would ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b3a044b20641eb707ff270a21ebb7f
https://doi.org/10.1158/1538-7445.sabcs17-pd8-01

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