TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.

Autor: Bröker-Lai J; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Rego Terol J; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Richter C; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Mathar I; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Wirth A; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Kopf S; Klinik für Endokrinologie, Diabetologie, Stoffwechsel und Klinische Chemie, Heidelberg, Germany.; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany., Moreno-Pérez A; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Büttner M; Metabolomics Core Technology Platform, Centre for Organismal Studies Heidelberg (COS Heidelberg), Heidelberg, Germany., Tan LL; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Makke M; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Poschet G; Metabolomics Core Technology Platform, Centre for Organismal Studies Heidelberg (COS Heidelberg), Heidelberg, Germany., Hermann J; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Tsvilovskyy V; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Haberkorn U; Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany., Wartenberg P; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Susperreguy S; Signal Transduction Laboratory, Institute of Biomedical Research (BIOMED UCA CONICET) Edificio San José, Piso 3 School of Biomedical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina., Berlin M; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Ottenheijm R; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Philippaert K; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Wu M; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany., Wiedemann T; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany., Herzig S; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany., Belkacemi A; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Levinson RT; Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany., Agarwal N; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Camacho Londoño JE; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Klebl B; Lead Discovery Center GmbH, Dortmund, Germany., Dinkel K; Lead Discovery Center GmbH, Dortmund, Germany., Zufall F; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Nussbaumer P; Lead Discovery Center GmbH, Dortmund, Germany., Boehm U; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Hell R; Metabolomics Core Technology Platform, Centre for Organismal Studies Heidelberg (COS Heidelberg), Heidelberg, Germany., Nawroth P; Klinik für Endokrinologie, Diabetologie, Stoffwechsel und Klinische Chemie, Heidelberg, Germany.; Deutsches Zentrum für Diabetesforschung (DZD e.V), München-Neuherberg, Germany., Birnbaumer L; Signal Transduction Laboratory, Institute of Biomedical Research (BIOMED UCA CONICET) Edificio San José, Piso 3 School of Biomedical Sciences, Pontifical Catholic University of Argentina, Buenos Aires, Argentina., Leinders-Zufall T; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Kuner R; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Zorn M; Klinik für Endokrinologie, Diabetologie, Stoffwechsel und Klinische Chemie, Heidelberg, Germany., Bruns D; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany., Schwarz Y; Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany. Yvonne.Schwarz@uks.eu., Freichel M; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany. Marc.Freichel@pharma.uni-heidelberg.de.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany. Marc.Freichel@pharma.uni-heidelberg.de.

Publikováno v: The EMBO journal [EMBO J] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.

Autor: Tsvilovskyy V; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Ottenheijm R; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Kriebs U; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Schütz A; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Diakopoulos KN; Comprehensive Cancer Center München, Chair for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany, Jha A; Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA., Bildl W; Institute for Physiology, University of Freiburg, Freiburg, Germany., Wirth A; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Böck J; Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany., Jaślan D; Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany., Ferro I; Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany., Taberner FJ; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, Sant Joan d'Alacant, Spain., Kalinina O; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany., Hildebrand S; Institut für Pharmakologie und Toxikologie, Universität Bonn, Bonn, Germany., Wissenbach U; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Weissgerber P; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Vogt D; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Eberhagen C; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Mannebach S; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Berlin M; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Kuryshev V; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Schumacher D; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Philippaert K; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Camacho-Londoño JE; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Mathar I; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Dieterich C; University Hospital Heidelberg, Department of Medicine III: Cardiology, Angiology and Pneumology, Heidelberg, Germany., Klugbauer N; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Fakultät für Medizin, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany., Biel M; Center for Integrated Protein Science Munich (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Wahl-Schott C; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Medical Faculty, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany., Lipp P; Institute for Molecular Cell Biology, Center for Molecular Signaling (PZMS), Universität des Saarlandes, Homburg, Germany., Flockerzi V; Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany., Zischka H; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Toxicology and Environmental Hygiene, Technical University Munich, School of Medicine, Munich, Germany., Algül H; Comprehensive Cancer Center München, Chair for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany, Lechner SG; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany., Lesina M; Comprehensive Cancer Center München, Chair for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany, Grimm C; Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany.; Immunology, Infection and Pandemic Research (IIP), Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Munich, Germany., Fakler B; Institute for Physiology, University of Freiburg, Freiburg, Germany., Schulte U; Institute for Physiology, University of Freiburg, Freiburg, Germany., Muallem S; Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA., Freichel M; Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Apr 01; Vol. 134 (7). Date of Electronic Publication: 2024 Apr 01.

Retrospective Analysis of Causes and Risk Factors of 30-Day Readmission After Spine Surgery for Thoracolumbar Trauma.

Autor: Camacho JE; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Kung JE; University of Maryland School of Medicine, Baltimore, MD, USA., Thomson AE; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Ye IB; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Gonzalez N; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Usmani MF; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Sokolow MJ; Business Intelligence and Regulatory Policy, University of Maryland Medical System, Baltimore, MD, USA., Bruckner JJ; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Cavanaugh DL; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Buraimoh K; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Koh EY; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Gelb DE; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Ludwig SC; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.

Publikováno v: Global spine journal [Global Spine J] 2023 Jul; Vol. 13 (6), pp. 1558-1565. Date of Electronic Publication: 2021 Sep 25.

Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1.

Autor: Yang L; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany., Ottenheijm R; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany., Worley P; The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Freichel M; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany., Camacho Londoño JE; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.

Publikováno v: Cells [Cells] 2022 Oct 14; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 14.

Postoperative outcomes of minimally invasive pedicle screw fixation for treatment of unstable pathologic neoplastic fractures.

Autor: Chin M; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Camacho JE; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Ye IB; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Bruckner JJ; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Thomson AE; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Jauregui JJ; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Buraimoh K; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Cavanaugh DL; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Koh EY; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Gelb DE; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA., Ludwig SC; Spine Surgery Division, Department of Orthopaedics, University of Maryland School of Medicine, 110 S. Paca Street, 6FL Ste. 300, Baltimore, MD, 21201, USA.

Publikováno v: Journal of orthopaedics [J Orthop] 2022 Feb 15; Vol. 30, pp. 72-76. Date of Electronic Publication: 2022 Feb 15 (Print Publication: 2022).