Zobrazeno 1 - 10
of 575
pro vyhledávání: '"JD Griffin"'
Publikováno v:
Blood. 80:1135-1140
Recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) produces dose-related therapeutic and toxic effects; however, relationships between its pharmacokinetics and pharmacodynamics have not been extensively evaluated. The foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f6ebf865366b2b503420205651a8e5
https://doi.org/10.1182/blood.v80.5.1135.bloodjournal8051135
https://doi.org/10.1182/blood.v80.5.1135.bloodjournal8051135
Publikováno v:
Blood. 79:2880-2887
Granulocyte-macrophage colony-stimulating factor (GM-CSF), Interleukin- 3 (IL-3), and Steel Factor (SF) induce proliferation of hematopoietic cells through binding to specific, high-affinity, cell surface receptors. However, little is known about pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030699a9032958e3c9d42b9862334648
https://doi.org/10.1182/blood.v79.11.2880.2880
https://doi.org/10.1182/blood.v79.11.2880.2880
Publikováno v:
Blood. 79:657-665
One of the mechanisms by which normal hematopoietic progenitor cells remain localized within the bone marrow microenvironment is likely to involve adhesion of these cells to extracellular matrix (ECM) proteins. For example, there is evidence that unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::219126aa2f4c91a758dcd8ba75957782
https://doi.org/10.1182/blood.v79.3.657.bloodjournal793657
https://doi.org/10.1182/blood.v79.3.657.bloodjournal793657
Autor:
A Kuriu, H Ikeda, Y Kanakura, JD Griffin, B Druker, H Yagura, H Kitayama, J Ishikawa, T Nishiura, Y Kanayama
Publikováno v:
Blood. 78:2834-2840
We investigated the expression, degree of phosphorylation, and activation of the proto-oncogene c-kit product before and after stimulation with the c-kit ligand in a human factor-dependent myeloid leukemia cell line, MO7E. The culture supernatant of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e140769b869f326a27ca23db8b80f915
https://doi.org/10.1182/blood.v78.11.2834.2834
https://doi.org/10.1182/blood.v78.11.2834.2834
Publikováno v:
Blood. 78:1834-1841
The common acute lymphoblastic leukemia antigen (CALLA, CD10), which is expressed on early lymphoid progenitors and neutrophils, is the zinc metalloprotease, neutral endopeptidase 24.11 (NEP, “enkephalinase”). The CD10 cell surface enzyme is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f508483463184feb5a7bf91b9af2de
https://doi.org/10.1182/blood.v78.7.1834.bloodjournal7871834
https://doi.org/10.1182/blood.v78.7.1834.bloodjournal7871834
Autor:
Y Kanakura, SA Cannistra, CB Brown, M Nakamura, GF Seelig, WW Prosise, JC Hawkins, K Kaushansky, JD Griffin
Publikováno v:
Blood. 77:1033-1043
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that is required for the survival, growth, and differentiation of hematopoietic progenitor cells. Although the primary structure of GM-CSF is known from cDNA cloning, the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4c5acdd5804c4c4da9ed3763aa5123
https://doi.org/10.1182/blood.v77.5.1033.bloodjournal7751033
https://doi.org/10.1182/blood.v77.5.1033.bloodjournal7751033
Publikováno v:
Blood. 77:243-248
The product of the c-raf-1 proto-oncogene, Raf-1, is a 74,000-dalton cytoplasmic serine/threonine protein kinase that has been implicated as an intermediate in signal transduction mechanisms. In the human factor- dependent myeloid cell line MO7, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1621c0e9b3c09a4f7dc74c570ed7c5
https://doi.org/10.1182/blood.v77.2.243.bloodjournal772243
https://doi.org/10.1182/blood.v77.2.243.bloodjournal772243
Publikováno v:
Blood. 84(3)
A decrease in responsiveness to granulocyte colony-stimulating factor (G-CSF) has been implicated in the pathophysiology of cyclic hematopoiesis. Using the canine model of cyclic neutropenia, we examined the response of neutrophil precursors to G-CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052d6ade993fef79002c53ffdd7dffde
https://pubmed.ncbi.nlm.nih.gov/7519075
https://pubmed.ncbi.nlm.nih.gov/7519075
Autor:
MJ Robertson, RJ Soiffer, AS Freedman, SL Rabinowe, KC Anderson, TJ Ervin, C Murray, K Dear, JD Griffin, LM Nadler
Publikováno v:
Blood. 79(9)
The CD33 antigen, identified by murine monoclonal antibody anti-MY9, is expressed by clonogenic leukemic cells from almost all patients with acute myeloid leukemia; it is also expressed by normal myeloid progenitor cells. Twelve consecutive patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c925287ec2271f522877c529a609de
https://pubmed.ncbi.nlm.nih.gov/1571539
https://pubmed.ncbi.nlm.nih.gov/1571539
Publikováno v:
Blood. 77(11)
The use of immunotoxins (IT) to selectively destroy acute myeloid leukemia (AML) cells in vivo or in vitro is complicated by both the antigenic similarity of AML cells to normal progenitor cells and the difficulty of producing a sufficiently toxic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76efbc2a4c9037953b878bec78087d05
https://pubmed.ncbi.nlm.nih.gov/2039821
https://pubmed.ncbi.nlm.nih.gov/2039821